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公开(公告)号：US20200246448A1
公开(公告)日：2020-08-06
申请号：US16774309
申请日：2020-01-28
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095 , A61K47/64 , A61K45/06 , A61K39/09
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20230355735A1
公开(公告)日：2023-11-09
申请号：US18338961
申请日：2023-06-21
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06
CPC classification number: A61K39/095 , A61K47/646 , A61K47/64 , A61K39/092 , A61K45/06 , A61K47/6415 , A61K2039/6068
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US11110160B2
公开(公告)日：2021-09-07
申请号：US16774309
申请日：2020-01-28
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06 , A61K39/00
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US09950054B2
公开(公告)日：2018-04-24
申请号：US15347034
申请日：2016-11-09
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K45/06 , A61K39/095 , A61K39/09 , A61K47/48 , A61K39/00
CPC classification number: A61K39/095 , A61K39/092 , A61K45/06 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US09517274B2
公开(公告)日：2016-12-13
申请号：US14420822
申请日：2013-08-12
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , A. Krishna Prasad , Yu-ying Yang
CPC classification number: A61K39/095 , A61K39/092 , A61K45/06 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
Abstract translation: 本发明提供了包含通过（2 - （（2-氧代乙基）硫基）乙基）氨基甲酸酯（eTEC）间隔物共价结合载体蛋白质的糖的eTEC连接的糖缀合物，包含这种糖缀合物的免疫原性组合物，以及制备和使用 这样的糖缀合物和免疫原性组合物。
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Patent Agency Ranking
6.发明公开公开(公告)号：US20240325515A1
公开(公告)日：2024-10-03
申请号：US18621962
申请日：2024-03-29
Applicant: Pfizer Inc.
Inventor： Kaushik Dutta , Caitlyn Gallagher , Isis Kanevsky , Jin-hwan Kim , Justin Keith Moran , Suddham Singh , Abhishek Ravindra Vartak
CPC classification number: A61K39/092 , A61K47/42 , A61P31/04 , A61K2039/55505
Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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公开(公告)号：US11723965B2
公开(公告)日：2023-08-15
申请号：US17395108
申请日：2021-08-05
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06 , A61K39/00
CPC classification number: A61K39/095 , A61K39/092 , A61K45/06 , A61K47/64 , A61K47/646 , A61K47/6415 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20220096619A1
公开(公告)日：2022-03-31
申请号：US17395108
申请日：2021-08-05
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US10583187B2
公开(公告)日：2020-03-10
申请号：US15946664
申请日：2018-04-05
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/395 , A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06 , A61K39/00
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20180221467A1
公开(公告)日：2018-08-09
申请号：US15946664
申请日：2018-04-05
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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