公开(公告)号：US10144781B2

公开(公告)日：2018-12-04

申请号：US15610417

申请日：2017-05-31

Applicant: PFIZER INC.

Inventor： Shu-Hui Liu ,  Flavia Mercer Pernasetti ,  Wei-Hsien Ho

IPC: C07H21/04 ,  C12N15/09 ,  C07K16/28 ,  A61K39/395 ,  A61K49/00 ,  A61K47/68 ,  C07K14/715 ,  A61K39/00

Abstract: The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.