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公开(公告)号：US10941216B2
公开(公告)日：2021-03-09
申请号：US15593259
申请日：2017-05-11
Applicant: PFIZER INC. , RINAT NEUROSCIENCE CORP.
Inventor： Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Shelton , Shu-Hui Liu , Jaume Pons , Russell Dushin
Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.
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Patent Agency Ranking
公开(公告)号：US10927178B2
公开(公告)日：2021-02-23
申请号：US16535477
申请日：2019-08-08
Applicant: PFIZER INC.
Inventor： Shu-Hui Liu , Flavia Mercer Pernasetti , Wei-Hsien Ho
IPC: C12N15/09 , C12N5/10 , C07K16/28 , C07K14/715 , A61K39/395 , C07H21/04 , A61K49/00 , A61K47/68 , A61K39/00
Abstract: The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.
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公开(公告)号：US09708405B2
公开(公告)日：2017-07-18
申请号：US14449478
申请日：2014-08-01
Applicant: Pfizer Inc.
Inventor： Shu-Hui Liu , Flavia Mercer Pernasetti , Wei-Hsien Ho
IPC: C07K16/28 , A61K39/395 , A61P35/00 , A61P35/02 , A61P35/04 , A61K47/48 , A61K49/00 , C07K14/715 , A61K39/00
CPC classification number: C07K16/2866 , A61K39/3955 , A61K47/6803 , A61K47/6809 , A61K47/6847 , A61K47/6849 , A61K47/6851 , A61K49/0002 , A61K2039/505 , C07H21/04 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N15/09
Abstract: The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.
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公开(公告)号：US10421815B2
公开(公告)日：2019-09-24
申请号：US16166830
申请日：2018-10-22
Applicant: PFIZER INC.
Inventor： Shu-Hui Liu , Flavia Mercer Pernasetti , Wei-Hsien Ho
IPC: C07H21/04 , C12N15/09 , C07K16/28 , A61K39/395 , A61K49/00 , A61K47/68 , C07K14/715 , A61K39/00
Abstract: The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.
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公开(公告)号：US20190092867A1
公开(公告)日：2019-03-28
申请号：US16166830
申请日：2018-10-22
Applicant: PFIZER INC.
Inventor： Shu-Hui Liu , Flavia Mercer Pernasetti , Weihsien Ho
IPC: C07K16/28 , C12N15/09 , A61K39/395 , C07H21/04 , A61K47/68 , A61K49/00 , C07K14/715 , A61K39/00
CPC classification number: C07K16/2866 , A61K39/3955 , A61K47/6803 , A61K47/6809 , A61K47/6847 , A61K47/6849 , A61K47/6851 , A61K49/0002 , A61K2039/505 , C07H21/04 , C07K14/7158 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N15/09
Abstract: The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.
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公开(公告)号：US10144781B2
公开(公告)日：2018-12-04
申请号：US15610417
申请日：2017-05-31
Applicant: PFIZER INC.
Inventor： Shu-Hui Liu , Flavia Mercer Pernasetti , Wei-Hsien Ho
IPC: C07H21/04 , C12N15/09 , C07K16/28 , A61K39/395 , A61K49/00 , A61K47/68 , C07K14/715 , A61K39/00
Abstract: The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.
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