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70 条记录 (耗时 0.028 秒)

    Osmotic drug delivery devices with hydrophobic wall materials
    11.
    发明授权
    Osmotic drug delivery devices with hydrophobic wall materials 失效
    具有疏水壁材料的渗透性药物输送装置

    公开(公告)号：US5795591A

    公开(公告)日：1998-08-18

    申请号：US299867

    申请日：1994-09-01

    申请人： Eun Soo Lee ,  Scott A. Bura ,  Su Il Yum ,  Patrick S.-L. Wong ,  Felix Theeuwes

    发明人： Eun Soo Lee ,  Scott A. Bura ,  Su Il Yum ,  Patrick S.-L. Wong ,  Felix Theeuwes

    IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K9/52 ,  A61K9/26

    CPC分类号： A61K9/0004

    摘要： Osmotically driven drug delivery devices with walls of porous hydrophobic material as the sole diffusion-limiting wall component are disclosed. Despite pores which are considerably larger than the molecular dimensions of osmotically active species in the interior of the device, despite pores which by their hydrophobic character do not permit the passage of liquid water, and despite the absence of a cellulosic semi-permeable membrane, the devices absorb water by osmosis without loss of the osmotically active species, and function in a manner analogous to osmotic pumps of the prior art. By permitting the use of hydrophobic substances as the wall material, the invention permits the device to be constructed entirely from biodegradable materials.

    摘要翻译： 公开了具有作为唯一扩散限制壁部件的多孔疏水材料壁的渗透驱动药物输送装置。 尽管孔远远大于装置内部的渗透活性物质的分子尺寸，尽管孔具有疏水性，但不允许液态水通过，尽管不存在纤维素半透膜， 装置通过渗透吸收水分而不损失渗透活性物质，并且以类似于现有技术的渗透泵的方式起作用。 通过允许使用疏水物质作为壁材料，本发明允许该装置完全由可生物降解的材料构成。

    Prolonged release active agent dosage form adapted for gastric retention
    13.
    发明授权
    Prolonged release active agent dosage form adapted for gastric retention 失效
    延长释放活性剂剂型适合胃潴留

    公开(公告)号：US06548083B1

    公开(公告)日：2003-04-15

    申请号：US09615110

    申请日：2000-07-13

    申请人： Patrick S.-L. Wong ,  Liang-Chang Dong ,  David E. Edgren ,  Felix Theeuwes ,  Phyllis I. Gardner ,  Francisco Jao ,  Jason J. Wan

    发明人： Patrick S.-L. Wong ,  Liang-Chang Dong ,  David E. Edgren ,  Felix Theeuwes ,  Phyllis I. Gardner ,  Francisco Jao ,  Jason J. Wan

    IPC分类号： A61K922

    CPC分类号： A61K9/0065 ,  A61K9/2072

    摘要： The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

    摘要翻译： 本发明涉及一种活性剂剂型，其适于保留在胃中并且可用于将活性剂制剂延长递送至使用的流体环境。 活性剂剂型是与胃液接触时膨胀的聚合物基质。 聚合物基质的一部分由不溶性材料带包围，其阻止聚合物基质的被覆盖部分膨胀，并提供具有足够刚性以抵抗胃收缩和延迟排出的部分的剂型 剂型，直到基本上所有的活性剂已被分配。

    Drug delivery device with minimal residual drug retention
    14.
    发明授权
    Drug delivery device with minimal residual drug retention 失效
    具有最小残留药物保留率的药物输送装置

    公开(公告)号：US5902605A

    公开(公告)日：1999-05-11

    申请号：US851525

    申请日：1997-04-18

    申请人： Liang C. Dong ,  Patrick S.-L. Wong ,  Si-Hong Yum ,  Crystal Pollock

    发明人： Liang C. Dong ,  Patrick S.-L. Wong ,  Si-Hong Yum ,  Crystal Pollock

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation of the device being of a predetermined length of time. The delivery of the agent formulation from the dispensing device is continued until essentially all of the active agent formulation is delivered as a result of the fluid inhibition into a fluid flow path in the housing of the device and the expansion of an expansion agent in the active agent delivery chamber.

    摘要翻译： 本发明涉及一种流体吸收药物递送装置，其可用于将活性剂制剂初始延迟递送至使用的流体环境，初始延迟时间为启动或启动装置的预定长度 时间。 药剂制剂从分配装置的输送继续进行，直到基本上所有的活性剂制剂由于液体抑制被输送到装置的壳体中的流体流动路径和活性物质中膨胀剂的膨胀而被递送 代理商送货室。

    Solid formulations of therapeutic proteins for gastrointestinal delivery
    17.
    发明授权
    Solid formulations of therapeutic proteins for gastrointestinal delivery 失效
    用于胃肠道输送的治疗性蛋白质的固体制剂

    公开(公告)号：US5424289A

    公开(公告)日：1995-06-13

    申请号：US99884

    申请日：1993-07-30

    申请人： Heechung Yang ,  Vu A. Nguyen ,  Liang C. Dong ,  Patrick S.-L. Wong

    发明人： Heechung Yang ,  Vu A. Nguyen ,  Liang C. Dong ,  Patrick S.-L. Wong

    IPC分类号： A61K9/16 ,  A61K38/27 ,  A61K38/28 ,  A61K47/12 ,  A61K47/44 ,  A61K38/00

    CPC分类号： A61K38/27 ,  A61K38/28 ,  A61K47/12 ,  A61K47/44 ,  A61K9/1617

    摘要： The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium salicylate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration, the amount of oil being from about 10 wt % to about 30 wt %, preferably from about 15 wt % to about 25 wt %, of the total formulation and the amount of sodium salicylate being from about 70 wt % to about 90 wt %, preferably from about 75 wt % to about 85 wt %, of the total formulation. The polypeptide may be non-lyophilized. The pharmaceutical formulation is characterized as a solid, which provides a convenient and improved format for handling and storage and for the preparation of oral dosage forms (such as pills, capsules and delivery vessels) containing a homogeneous mixture of ingredients.

    摘要翻译： 本发明涉及治疗性多肽的药物制剂以及水杨酸钠和油的渗透增强混合物，以在口服给药之后通过胃肠道壁，特别是结肠壁提供增强的多肽吸收 ，油的量为总制剂的约10重量％至约30重量％，优选约15重量％至约25重量％，水杨酸钠的量为约70重量％至约90重量％ ，优选约75重量％至约85重量％。 多肽可以是非冻干的。 药物制剂的特征在于固体，其提供用于处理和储存的方便和改进的形式，以及用于制备含有均匀成分混合物的口服剂型（例如丸剂，胶囊和递送容器）。