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公开(公告)号:US20050037354A1
公开(公告)日:2005-02-17
申请号:US10494123
申请日:2002-10-25
申请人: Kurt Berlin , Aron Braun , Peter Adorjan
发明人: Kurt Berlin , Aron Braun , Peter Adorjan
CPC分类号: C12Q1/6809 , G16B40/00 , G16B50/00
摘要: A method for epigenetic knowledge generation which designs and synthesizes the chemical and/or biological components that determine the epigenetic parameters to be selected and measured is described. The value of these epigenetic parameters is determined, the steps of this procedure repeated and finally the results are stored. The present invention relates to a method of epigenetic knowledge generation comprising the steps of: a. selecting epigenetic parameters of interest; b. designing the chemical and/or biological components of the epigenetic measurement system, wherein the chemical and/or biological components determine the epigenetic parameters to be measured; c. synthesizing the variable chemical and/or biological components; d. measuring the value of the epigenetic parameters using the chemical and/or biological components; e. storing the results obtained by measurement; f. defining a subset of epigenetic parameters of interest based on the measurements; g. repeating steps a-d.
摘要翻译: 描述了设计和合成确定待选择和测量的表观遗传参数的化学和/或生物组分的表观遗传知识产生的方法。 确定这些表观遗传参数的值,重复该过程的步骤,最后存储结果。 本发明涉及一种表观遗传知识产生方法,包括以下步骤:a。 选择感兴趣的表观遗传参数; b。 设计表观遗传学测量系统的化学和/或生物组分,其中所述化学和/或生物组分决定待测量的表观遗传参数; C。 合成可变化学和/或生物成分; d。 使用化学和/或生物成分测量表观遗传参数的值; e。 存储通过测量获得的结果; F。 基于测量定义感兴趣的表观遗传参数的子集; G。 重复步骤a-d。
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12.
公开(公告)号:US07381808B2
公开(公告)日:2008-06-03
申请号:US10172086
申请日:2002-06-13
申请人: Juergen Distler , Fabian Model , Peter Adorjan
发明人: Juergen Distler , Fabian Model , Peter Adorjan
CPC分类号: C12Q1/6827 , B01J2219/00497 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C12Q1/6886 , C12Q2600/154 , C40B40/06 , C12Q2565/627 , C12Q2523/125
摘要: The present invention relates to chemically modified genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in characterisation, classification, differentiation, diagnosis and therapy of prostate lesions.
摘要翻译: 本发明涉及化学修饰的基因组序列,用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体,以及用于确定用于表征,分类的基因的遗传和/或表观遗传学参数的方法 ,前列腺损伤的分化,诊断和治疗。
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