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公开(公告)号：US07381808B2
公开(公告)日：2008-06-03
申请号：US10172086
申请日：2002-06-13
申请人： Juergen Distler , Fabian Model , Peter Adorjan
发明人： Juergen Distler , Fabian Model , Peter Adorjan
CPC分类号： C12Q1/6827 , B01J2219/00497 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C12Q1/6886 , C12Q2600/154 , C40B40/06 , C12Q2565/627 , C12Q2523/125
摘要： The present invention relates to chemically modified genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in characterisation, classification, differentiation, diagnosis and therapy of prostate lesions.
摘要翻译： 本发明涉及化学修饰的基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于确定用于表征，分类的基因的遗传和/或表观遗传学参数的方法 ，前列腺损伤的分化，诊断和治疗。
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2.发明申请公开(公告)号：US20060024684A1
公开(公告)日：2006-02-02
申请号：US11011332
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.
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3.发明申请Methods and computer program products for the quality control of nucleic acid assay 审中-公开方法和计算机程序产品，用于核酸测定的质量控制公开(公告)号：US20050255467A1
公开(公告)日：2005-11-17
申请号：US10509449
申请日：2003-03-28
申请人： Peter Adorjan , Fabian Model , Thomas Konig , Christian Piepenbrock , Klaus Junemann , Matthias Burger , Susanne Schwenke
发明人： Peter Adorjan , Fabian Model , Thomas Konig , Christian Piepenbrock , Klaus Junemann , Matthias Burger , Susanne Schwenke
摘要： The disclosed invention provides methods and computer program products for the improved verification and controlling of assays for the analysis of nucleic acid variations by means of statistical process control. The invention is characterised in that variables of each experiment are monitored by measuring deviations of said variables from a reference data set and wherein said experiments or batches thereof are indicated as unsuitable for further interpretation if they exceed predetermined limits.
摘要翻译： 所公开的发明提供了用于通过统计过程控制来改进对核酸变异分析的测定的验证和控制的方法和计算机程序产品。 本发明的特征在于，通过测量所述变量与参考数据集的偏差来监测每个实验的变量，并且其中所述实验或其批次被指示为不适合进一步解释，如果它们超过预定限度。
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公开(公告)号：US09017944B2
公开(公告)日：2015-04-28
申请号：US10582705
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John W. Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth Lukas , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John W. Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth Lukas , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译： 本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与细胞的无病存活和/或应答的方法 乳腺组织增生性疾病，进行内分泌治疗。
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5.发明申请公开(公告)号：US20080254447A1
公开(公告)日：2008-10-16
申请号：US10582705
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译： 本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与细胞的无病存活和/或应答的方法 乳腺组织增生性疾病，进行内分泌治疗。
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公开(公告)号：US20050037354A1
公开(公告)日：2005-02-17
申请号：US10494123
申请日：2002-10-25
申请人： Kurt Berlin , Aron Braun , Peter Adorjan
发明人： Kurt Berlin , Aron Braun , Peter Adorjan
CPC分类号： C12Q1/6809 , G16B40/00 , G16B50/00
摘要： A method for epigenetic knowledge generation which designs and synthesizes the chemical and/or biological components that determine the epigenetic parameters to be selected and measured is described. The value of these epigenetic parameters is determined, the steps of this procedure repeated and finally the results are stored. The present invention relates to a method of epigenetic knowledge generation comprising the steps of: a. selecting epigenetic parameters of interest; b. designing the chemical and/or biological components of the epigenetic measurement system, wherein the chemical and/or biological components determine the epigenetic parameters to be measured; c. synthesizing the variable chemical and/or biological components; d. measuring the value of the epigenetic parameters using the chemical and/or biological components; e. storing the results obtained by measurement; f. defining a subset of epigenetic parameters of interest based on the measurements; g. repeating steps a-d.
摘要翻译： 描述了设计和合成确定待选择和测量的表观遗传参数的化学和/或生物组分的表观遗传知识产生的方法。 确定这些表观遗传参数的值，重复该过程的步骤，最后存储结果。 本发明涉及一种表观遗传知识产生方法，包括以下步骤：a。 选择感兴趣的表观遗传参数; b。 设计表观遗传学测量系统的化学和/或生物组分，其中所述化学和/或生物组分决定待测量的表观遗传参数; C。 合成可变化学和/或生物成分; d。 使用化学和/或生物成分测量表观遗传参数的值; e。 存储通过测量获得的结果; F。 基于测量定义感兴趣的表观遗传参数的子集; G。 重复步骤a-d。
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公开(公告)号：US20070178453A1
公开(公告)日：2007-08-02
申请号：US10523062
申请日：2003-08-01
CPC分类号： C12Q1/6858 , C12Q2600/156
摘要： The invention describes a method for amplifying nucleic acids, such as DNA with means of an enzymatic amplification step, such as a polymerase chain reaction, specified for template nucleic acids of low complexity, e.g. pre-treated DNA, like but not limited to DNA pre-treated with bisulfite is disclosed. The invention is based on the use of specific oligo-nucleotide primer molecules to solely amplify specific pieces of DNA. It is disclosed how to optimize the primer design for a PCR if the template DNA is of low complexity.
摘要翻译： 本发明描述了用于通过酶促扩增步骤（例如聚合酶链式反应）来扩增核酸例如DNA的方法，所述酶扩增步骤是针对低复杂度的模板核酸例如特异的。 公开了预处理的DNA，例如但不限于用亚硫酸氢盐预处理的DNA。 本发明基于使用特异性寡核苷酸引物分子来单独扩增特定的DNA片段。 如果模板DNA的复杂度低，那么披露如何优化PCR的引物设计。
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8.发明申请Method and nucleic acids for the analysis of a colon cell proliferative disorder 审中-公开用于分析结肠细胞增殖性疾病的方法和核酸公开(公告)号：US20060246433A1
公开(公告)日：2006-11-02
申请号：US10506111
申请日：2003-02-27
申请人： Peter Adorjan , Matthias Burger , Sabine Maier , Inko Nimmrich , Evelyne Becker , Ralf Lesche , Tamas Rujan , Armin Schmitt
发明人： Peter Adorjan , Matthias Burger , Sabine Maier , Inko Nimmrich , Evelyne Becker , Ralf Lesche , Tamas Rujan , Armin Schmitt
CPC分类号： C12Q1/6886 , C12Q2600/154 , Y10T436/143333
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of colon cell proliferative disorders, or the predisposition to colon cell proliferative disorders.
摘要翻译： 本发明涉及修饰和基因组序列，寡核苷酸和/或PNA寡聚物，用于检测基因组DNA的胞嘧啶甲基化状态，以及一种用于在分化确定基因的遗传和/或后生参数以供使用， 诊断，治疗和/或结肠细胞增殖性疾病的监测，或易患结肠癌细胞增殖性疾病。
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9.发明申请Method and nucleic acids for the analysis of colon cell proliferative disorders 审中-公开用于分析结肠细胞增殖性疾病的方法和核酸公开(公告)号：US20060234224A1
公开(公告)日：2006-10-19
申请号：US10506089
申请日：2003-02-27
申请人： Peter Adorjan , Matthias Burger , Sabine Maier , Ralf Lesche , Susan Cottrell , Suzanne Mooney
发明人： Peter Adorjan , Matthias Burger , Sabine Maier , Ralf Lesche , Susan Cottrell , Suzanne Mooney
CPC分类号： C12Q1/6886 , C12Q2600/154 , Y10T436/143333
摘要： The invention provides methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders by analysis of one or more of the genes Versican, TPEF, H-Cadherin, Calcitonin, and EYA4. The invention further provides novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said genes as well as methods, assays and kits thereof.
摘要翻译： 本发明提供了通过分析一种或多种基因Versican，TPEF，H-钙粘着蛋白，降钙素和EYA4来检测，分化或鉴别结肠细胞增殖性疾病的方法和核酸。 本发明还提供了用于所述基因的细胞增殖性病症特异性分析的新型核酸序列及其方法，测定和试剂盒。
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10.发明申请Method and nucleic acids for the analysis of colorectal cell proliferative disorders 失效用于分析结肠直肠细胞增殖性疾病的方法和核酸公开(公告)号：US20050003463A1
公开(公告)日：2005-01-06
申请号：US10482823
申请日：2003-02-13
申请人： Peter Adorjan , Matthias Burger , Sabine Maier , Ralf Lesche , Susan Cottrell , Theo De Vos
发明人： Peter Adorjan , Matthias Burger , Sabine Maier , Ralf Lesche , Susan Cottrell , Theo De Vos
IPC分类号： G01N27/62 , A61K48/00 , A61P35/00 , A61P43/00 , C12M1/00 , C12N15/09 , C12Q1/02 , G01N21/78 , G01N33/53 , G01N33/543 , G01N33/574 , G01N33/58 , G01N37/00 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , Y10T436/143333
摘要： The invention provides methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders as well as therapy thereof by analysis of the gene EYA4 and its promoter and regulatory sequences. The invention further provides novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said gene as well as methods, assays and kits thereof.
摘要翻译： 本发明提供了通过分析基因EYA4及其启动子和调节序列来检测，分化或区分结肠细胞增殖性疾病以及其治疗的方法和核酸。 本发明还提供了可用于所述基因的细胞增殖性病症特异性分析的新型核酸序列及其方法，测定及试剂盒。
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