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公开(公告)号：US10208019B2
公开(公告)日：2019-02-19
申请号：US15839901
申请日：2017-12-13
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D401/14 , A61K31/496 , A61K31/4545 , A61P15/10 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , A61P3/00
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US20140315928A1
公开(公告)日：2014-10-23
申请号：US14253084
申请日：2014-04-15
Applicant: Pfizer Inc.
Inventor： Etzer Darout , Robert Dullea , Julie Jia Li Hawkins , Allyn T. Londregan , Paula M. Loria , Bruce Maguire , Kim F. McClure , Donna N. Petersen , David W. Piotrowski
IPC: C07D401/14 , A61K31/519 , A61K45/06 , C07D413/14 , A61K31/437 , A61K31/4709 , A61K31/4545 , C07D487/04 , C07D471/04
CPC classification number: A61K31/519 , A61K31/4545 , A61K31/4725 , A61K45/06 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.
Abstract translation: 本发明涉及取代的酰胺化合物，含有这些化合物的药物组合物以及这些化合物用于降低血浆脂质水平的用途，例如LDL-胆固醇和甘油三酸酯，并因此治疗由高水平的LDL-胆固醇加重的疾病， 甘油三酸酯，如动脉粥样硬化和心血管疾病，包括人在内的哺乳动物。
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公开(公告)号：US11858916B2
公开(公告)日：2024-01-02
申请号：US17251929
申请日：2019-06-13
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , Edward L. Conn , John M. Curto , David J. Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/14 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04
CPC classification number: C07D405/14 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US20210332034A1
公开(公告)日：2021-10-28
申请号：US17251929
申请日：2019-06-13
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , Edward L. Conn , John M. Curto , David J. Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/14 , C07D471/04 , C07D401/14 , C07D413/14 , C07D403/14
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US10683281B2
公开(公告)日：2020-06-16
申请号：US16535553
申请日：2019-08-08
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , David James Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Yajing Lian , Chris Limberakis , Allyn T. Londregan , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/12 , C07D405/14 , C07C53/06 , C07C53/10 , C07C215/40 , C07D413/14 , C07D471/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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Patent Agency Ranking
公开(公告)号：US20190382384A1
公开(公告)日：2019-12-19
申请号：US16436311
申请日：2019-06-10
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , David James Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Yajing Lian , Chris Limberakis , Allyn T. Londregan , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/12 , C07D471/04 , C07D405/14 , C07D413/14 , C07C53/06 , C07C53/10 , C07C215/40
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US20180170908A1
公开(公告)日：2018-06-21
申请号：US15839901
申请日：2017-12-13
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D401/14 , C07D471/04 , C07D405/14 , C07D413/14 , A61P3/10 , A61P25/28 , A61P25/02 , A61P13/12 , A61P43/00 , A61P3/04 , A61P1/16 , A61P9/10 , A61P19/02 , A61P25/16 , A61P19/06 , A61P15/10 , A61P17/06 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/30
CPC classification number: C07D401/14 , A61K31/4545 , A61K31/496 , A61P1/00 , A61P1/16 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/10 , A61P13/12 , A61P15/00 , A61P15/10 , A61P17/06 , A61P19/02 , A61P19/06 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/30 , A61P43/00 , C07D405/14 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US09227956B2
公开(公告)日：2016-01-05
申请号：US14253084
申请日：2014-04-15
Applicant: Pfizer Inc.
Inventor： Etzer Darout , Robert Dullea , Julie Jia Li Hawkins , Allyn T. Londregan , Paula M. Loria , Bruce Maguire , Kim F. McClure , Donna N. Petersen , David W. Piotrowski
IPC: C07D401/14 , A61K31/519 , A61K45/06 , C07D413/14 , A61K31/437 , A61K31/4709 , A61K31/4545 , C07D487/04 , C07D471/04
CPC classification number: A61K31/519 , A61K31/4545 , A61K31/4725 , A61K45/06 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.
Abstract translation: 本发明涉及取代的酰胺化合物，含有这些化合物的药物组合物以及这些化合物用于降低血浆脂质水平的用途，例如LDL-胆固醇和甘油三酸酯，并因此治疗由高水平的LDL-胆固醇加重的疾病， 甘油三酸酯，如动脉粥样硬化和心血管疾病，包括人在内的哺乳动物。
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公开(公告)号：US20240132483A1
公开(公告)日：2024-04-25
申请号：US18513752
申请日：2023-11-20
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , Edward L. Conn , John M. Curto , David J. Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D405/14 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04
CPC classification number: C07D405/14 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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公开(公告)号：US20230124938A1
公开(公告)日：2023-04-20
申请号：US18049052
申请日：2022-10-24
Applicant: Pfizer Inc.
Inventor： Gary Erik Aspnes , Scott W. Bagley , John M. Curto , Matthew S. Dowling , David Edmonds , Mark E. Flanagan , Kentaro Futatsugi , David A. Griffith , Kim Huard , Gajendra Ingle , Wenhua Jiao , Chris Limberakis , Alan M. Mathiowetz , David W. Piotrowski , Roger B. Ruggeri
IPC: C07D401/14 , A61K31/496 , A61K31/4545 , C07D487/04 , A61P3/00 , A61P15/10 , A61P17/06 , A61P9/10 , A61P19/06 , A61P25/28 , A61P25/30 , A61P43/00 , A61P1/16 , A61P25/02 , A61P3/04 , A61P19/02 , A61P3/10 , A61P13/12 , A61P25/18 , A61P1/00 , A61P15/00 , A61P25/16 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
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