公开(公告)号：US20220251075A1

公开(公告)日：2022-08-11

申请号：US17620188

申请日：2020-06-17

Applicant: Pfizer Inc. ,  CTXT PTY LTD

Inventor： Oleg Brodsky ,  Samantha Elizabeth Greasley ,  Robert Louis Hoffman ,  Pei-Pei Kung ,  Paul Francis Richardson ,  Paul Anthony Stupple

IPC: C07D413/14 ,  C07D413/06

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ring A, Y, R1-R8, m, n and p are defined herein. The novel cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in patients.

公开(公告)号：US09593097B2

公开(公告)日：2017-03-14

申请号：US14968405

申请日：2015-12-14

Applicant: Pfizer Inc.

Inventor： Ted William Johnson ,  Paul Francis Richardson ,  Michael Raymond Collins ,  Daniel Tyler Richter ,  Benjamin Joseph Burke ,  Sacha Ninkovic ,  Ketan Satish Gajiwala ,  Maria Angelica Linton ,  Phuong Thi Quy Le ,  Jacqui Elizabeth Hoffman

IPC: C07D401/14 ,  C07D403/14 ,  A61K31/53 ,  A61K31/506 ,  A61K31/4523 ,  A61P35/00 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D401/14 ,  A61K31/4523 ,  A61K31/506 ,  A61K31/53 ,  C07D403/14 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract translation: 通式（I）的化合物：这些化合物的制备方法，含有这些化合物的组合物，以及这些化合物的用途。

公开(公告)号：US20160176850A1

公开(公告)日：2016-06-23

申请号：US14968405

申请日：2015-12-14

Applicant: Pfizer Inc.

Inventor： Ted William Johnson ,  Paul Francis Richardson ,  Michael Raymond Collins ,  Daniel Tyler Richter ,  Benjamin Joseph Burke ,  Sacha Ninkovic ,  Ketan Satish Gajiwala ,  Maria Angelica Linton ,  Phuong Thi Quy Le ,  Jacqui Elizabeth Hoffman

IPC: C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  C07D405/14

CPC classification number: C07D401/14 ,  A61K31/4523 ,  A61K31/506 ,  A61K31/53 ,  C07D403/14 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract translation: 通式（I）的化合物：这些化合物的制备方法，含有这些化合物的组合物，以及这些化合物的用途。