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公开(公告)号：US20190040055A1
公开(公告)日：2019-02-07
申请号：US16157618
申请日：2018-10-11
Applicant: Pfizer Inc.
Inventor： Aaron Craig Burns , Michael Raymond Collins , Samantha Elizabeth Greasley , Robert Louis Hoffman , Peter Qinhua Huang , Robert Steven Kania , Pei-Pei Kung , Maria Angelica Linton , Lakshmi Sourirajan Narasimhan , Paul Francis Richardson , Daniel Tyler Richter , Graham Smith
IPC: C07D417/14 , C07D417/08 , C07D277/46 , A61K45/06 , A61K31/427 , A61K31/501 , A61K31/444 , A61K31/4439 , C07D401/14 , A61K31/506
Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
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公开(公告)号：US10676471B2
公开(公告)日：2020-06-09
申请号：US16416997
申请日：2019-05-20
Applicant: Pfizer Inc.
Inventor： Aaron Craig Burns , Michael Raymond Collins , Samantha Elizabeth Greasley , Robert Louis Hoffman , Peter Qinhua Huang , Robert Steven Kania , Pei-Pei Kung , Maria Angelica Linton , Lakshmi Sourirajan Narasimhan , Paul Francis Richardson , Daniel Tyler Richter , Graham Smith
IPC: C07D417/14 , C07D401/14 , C07D417/08 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/501 , A61K31/506 , A61K45/06 , C07D277/46
Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
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公开(公告)号：US20190270737A1
公开(公告)日：2019-09-05
申请号：US16416997
申请日：2019-05-20
Applicant: Pfizer Inc.
Inventor： Aaron Craig Burns , Michael Raymond Collins , Samantha Elizabeth Greasley , Robert Louis Hoffman , Peter Qinhua Huang , Robert Steven Kania , Pei-Pei Kung , Maria Angelica Linton , Lakshmi Sourirajan Narasimhan , Paul Francis Richardson , Daniel Tyler Richter , Graham Smith
IPC: C07D417/14 , C07D417/08
Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
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Patent Agency Ranking
公开(公告)号：US10662204B2
公开(公告)日：2020-05-26
申请号：US16263185
申请日：2019-01-31
Applicant: PFIZER INC.
Inventor： Simon Planken , Hengmiao Cheng , Michael Raymond Collins , Jillian Elyse Spangler , Alexei Brooun , Andreas Maderna , Cynthia Palmer , Maria Angelica Linton , Asako Nagata , Ping Chen
IPC: C07D403/12 , C07D403/14 , C07D407/14 , C07D487/10 , A61P35/00 , C07D519/00 , C07D471/04 , C07D487/04 , C07D417/14 , C07D413/14 , A61P25/00
Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and administration of these compounds to patients to treat pancreatic, lung, colon and other cancers.
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公开(公告)号：US10590115B2
公开(公告)日：2020-03-17
申请号：US16265012
申请日：2019-02-01
Applicant: PFIZER INC.
Inventor： Simon Planken , Hengmiao Cheng , Michael Raymond Collins , Jillian Elyse Spangler , Alexei Brooun , Andreas Maderna , Cynthia Palmer , Maria Angelica Linton , Asako Nagata , Ping Chen
IPC: C07D403/14 , C07D487/10 , A61P35/00 , C07D403/04 , C07D239/94
Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US10125130B2
公开(公告)日：2018-11-13
申请号：US15826027
申请日：2017-11-29
Applicant: PFIZER INC.
Inventor： Aaron Craig Burns , Michael Raymond Collins , Samantha Elizabeth Greasley , Robert Louis Hoffman , Peter Qinhua Huang , Robert Steven Kania , Pei-Pei Kung , Maria Angelica Linton , Lakshmi Sourirajan Narasimhan , Paul Francis Richardson , Daniel Tyler Richter , Graham Smith
IPC: C07D417/14 , C07D417/08 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/501 , A61K31/506 , A61K45/06 , C07D277/46 , C07D401/14
Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
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公开(公告)号：US09593097B2
公开(公告)日：2017-03-14
申请号：US14968405
申请日：2015-12-14
Applicant: Pfizer Inc.
Inventor： Ted William Johnson , Paul Francis Richardson , Michael Raymond Collins , Daniel Tyler Richter , Benjamin Joseph Burke , Sacha Ninkovic , Ketan Satish Gajiwala , Maria Angelica Linton , Phuong Thi Quy Le , Jacqui Elizabeth Hoffman
IPC: C07D401/14 , C07D403/14 , A61K31/53 , A61K31/506 , A61K31/4523 , A61P35/00 , C07D405/14 , C07D471/04 , C07D487/04
CPC classification number: C07D401/14 , A61K31/4523 , A61K31/506 , A61K31/53 , C07D403/14 , C07D405/14 , C07D471/04 , C07D487/04
Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
Abstract translation: 通式（I）的化合物：这些化合物的制备方法，含有这些化合物的组合物，以及这些化合物的用途。
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公开(公告)号：US20160176850A1
公开(公告)日：2016-06-23
申请号：US14968405
申请日：2015-12-14
Applicant: Pfizer Inc.
Inventor： Ted William Johnson , Paul Francis Richardson , Michael Raymond Collins , Daniel Tyler Richter , Benjamin Joseph Burke , Sacha Ninkovic , Ketan Satish Gajiwala , Maria Angelica Linton , Phuong Thi Quy Le , Jacqui Elizabeth Hoffman
IPC: C07D401/14 , C07D471/04 , C07D487/04 , C07D405/14
CPC classification number: C07D401/14 , A61K31/4523 , A61K31/506 , A61K31/53 , C07D403/14 , C07D405/14 , C07D471/04 , C07D487/04
Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
Abstract translation: 通式（I）的化合物：这些化合物的制备方法，含有这些化合物的组合物，以及这些化合物的用途。
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