公开(公告)号：US10238732B2

公开(公告)日：2019-03-26

申请号：US15896871

申请日：2018-02-14

Applicant: Pfizer Inc.

Inventor： Ye Che ,  Philip Ralph Dormitzer ,  Alexey Vyacheslavovich Gribenko ,  Luke David Handke ,  Avvari Krishna Prasad ,  Xiayang Qiu ,  Mark Edward Ruppen ,  Xi Song ,  Kena Anne Swanson ,  Srinivas Kodali ,  Xin Xu ,  KariAnn Sweeney Efferen ,  Ping Cai ,  Kristin Rachael Tompkins ,  Lorna del Pilar Nunez

IPC: A61K39/155 ,  C07K14/135 ,  C12N15/01 ,  C07K14/005 ,  C12N7/00 ,  A61K39/12 ,  A61K39/00

Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.

公开(公告)号：US20180177864A1

公开(公告)日：2018-06-28

申请号：US15896871

申请日：2018-02-14

Applicant: Pfizer Inc.

Inventor： Ye Che ,  Philip Ralph Dormitzer ,  Alexey Vyacheslavovich Gribenko ,  Luke David Handke ,  Avvari Krishna Prasad ,  Xiayang Qiu ,  Mark Edward Ruppen ,  Xi Song ,  Kena Anne Swanson ,  Srinivas Kodali ,  Xin Xu ,  KariAnn Sweeney Efferen ,  Ping Cai ,  Kristin Rachael Tompkins ,  Lorna del Pilar Nunez

IPC: A61K39/155 ,  A61K39/12

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K2039/575 ,  C07K14/005 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/40 ,  C07K2319/70 ,  C07K2319/735 ,  C12N7/00 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.

公开(公告)号：US11857622B2

公开(公告)日：2024-01-02

申请号：US17350008

申请日：2021-06-17

Applicant: Pfizer Inc.

Inventor： Yuhang Liu ,  Ye Che ,  Xiaoyuan Sherry Chi ,  Philip Ralph Dormitzer ,  Jennifer Anne Nicki ,  Xiaojie Yao

IPC: A61K39/245 ,  C07K14/045 ,  C12N7/00

CPC classification number: A61K39/245 ,  C07K14/045 ,  C12N7/00 ,  C12N2710/16134

Abstract: The present invention comprises mutants of a wild-type cytomegalovirus (CMV) glycoprotein B (gB) protein that include at least two introduced amino acid mutations relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB), compositions including the mutants and uses thereof. In some embodiments, the mutant is stabilized in a conformation alternative to the gB postfusion conformation.

公开(公告)号：US11629172B2

公开(公告)日：2023-04-18

申请号：US16721229

申请日：2019-12-19

Applicant: Pfizer Inc.

Inventor： Philip Ralph Dormitzer ,  Ye Che ,  Xiaoyuan Sherry Chi ,  Seungil Han ,  Kyle Paul Heim ,  Thomas Richard Jones ,  Yuhang Liu ,  Xiayang Qiu ,  Xinzhen Yang ,  Xiaojie Yao ,  Matthew Curtis Griffor ,  Jennifer Anne Nicki

IPC: C07K14/005 ,  A61K39/00

Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.

公开(公告)号：US20200247853A1

公开(公告)日：2020-08-06

申请号：US16721229

申请日：2019-12-19

Applicant: Pfizer Inc.

Inventor： Philip Ralph Dormitzer ,  Ye Che ,  Xiaoyuan Sherry Chi ,  Seungil Han ,  Kyle Paul Heim ,  Thomas Richard Jones ,  Yuhang Liu ,  Xiayang Qiu ,  Xinzhen Yang ,  Xiaojie Yao ,  Matthew Curtis Griffor ,  Jennifer Anne Nicki

IPC: C07K14/005

Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.

公开(公告)号：US20170182151A1

公开(公告)日：2017-06-29

申请号：US15385611

申请日：2016-12-20

Applicant: Pfizer Inc.

Inventor： Ye Che ,  Philip Ralph Dormitzer ,  Alexey Vyacheslavovich Gribenko ,  Luke David Handke ,  Avvari Krishna Prasad ,  Xiayang Qiu ,  Mark Edward Ruppen ,  Xi Song ,  Kena Anne Swanson ,  Srinivas Kodali ,  Xin Xu ,  KariAnn Sweeney Efferen ,  Ping Cai ,  Kristin Rachael Tompkins ,  Lorna del Pilar Nunez

IPC: A61K39/155 ,  C07K14/005 ,  C12N7/00

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K2039/575 ,  C07K14/005 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/40 ,  C07K2319/70 ,  C07K2319/735 ,  C12N7/00 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.