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公开(公告)号：US11635256B2
公开(公告)日：2023-04-25
申请号：US17588929
申请日：2022-01-31
Applicant: Purdue Research Foundation
Inventor： Andrew Strongrich , Alina Alexeenko
Abstract: A system to monitor and control a lyophilization process using a wireless network is disclosed which includes one or more wireless pressure and gas temperature sensors adapted to provide pressure and gas temperature measurements of the ambient environment, a lyophilization chamber, wherein the one or more wireless pressure sensors are distributed in one or more lyophilization vial trays, a vacuum pump, adapted to change the pressure with the lyophilization chamber, a heat exchanger adapted to modify temperature within the lyophilization chamber, and a controller adapted to collect pressure and gas temperature data from the one or more wireless pressure and gas temperature sensors, calculate sublimation rate of a product to be lyophilized using the collected pressure and gas temperature data, and adjust one or both of pressure and temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope.
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公开(公告)号：US20220341859A9
公开(公告)日：2022-10-27
申请号：US16233023
申请日：2018-12-26
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Andrew Strongrich
IPC: G01N25/00
Abstract: A microelectromechanical (MEMS) gas sensor operating based on Knudsen thermal force is disclosed. The sensor includes a substrate, at least one stationary assembly that is fixedly coupled to the substrate, and at least one moveable assembly that is positioned above the substrate which is biased to move substantially according to a main axis and juxtaposed with the at least one stationary assembly.
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公开(公告)号：US20220155010A1
公开(公告)日：2022-05-19
申请号：US17588929
申请日：2022-01-31
Applicant: Purdue Research Foundation
Inventor： Andrew Strongrich , Alina Alexeenko
Abstract: A system to monitor and control a lyophilization process using a wireless network is disclosed which includes one or more wireless pressure and gas temperature sensors adapted to provide pressure and gas temperature measurements of the ambient environment, a lyophilization chamber, wherein the one or more wireless pressure sensors are distributed in one or more lyophilization vial trays, a vacuum pump, adapted to change the pressure with the lyophilization chamber, a heat exchanger adapted to modify temperature within the lyophilization chamber, and a controller adapted to collect pressure and gas temperature data from the one or more wireless pressure and gas temperature sensors, calculate sublimation rate of a product to be lyophilized using the collected pressure and gas temperature data, and adjust one or both of pressure and temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope.
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公开(公告)号：US11878818B2
公开(公告)日：2024-01-23
申请号：US17447061
申请日：2021-09-07
Applicant: Purdue Research Foundation
Inventor： Steven M. Pugia , Anthony G. Cofer , Alina Alexeenko
Abstract: A microthruster for controlling small spacecraft and methods for manufacturing the same are disclosed. Embodiments of the microthruster include one or more nozzle throats with cross sectional areas of at most 20 μm2, and some with 6 μm2. Some embodiments include heaters that heat water in one or more reservoirs to increase pressure in the reservoirs and eject the water from the one or more nozzle throats. Some embodiments are manufactured by etching channels into one or more layers of material, and still further embodiments are manufactured by forming the nozzle throats and/or the reservoirs between two layers of material. Some microthruster embodiments are flat in shape with the nozzle throats ejecting water out the thin sides of the microthruster. Still further embodiments are formed by etching channels into one layer of material, printing a heater onto another layer of material, and bonding the two layers together.
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公开(公告)号：US11719261B2
公开(公告)日：2023-08-08
申请号：US16593066
申请日：2019-10-04
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Katherine L Fowee , Steven M Pugia , Steven Collicott , Anthony Cofer
Abstract: A vapor-pressure driven micro pump system comprising an enclosure of a supporting structure; a first chamber having a first volatile material as a propellant with a plurality of exit nozzles; a second chamber have a second volatile material inside of a collapsible diaphragm which separates the first and the second chambers within said enclosure, wherein a vacuum at the plurality of exit nozzles causes vaporization of said propellant, which is compensated and displaced by vapor of said second volatile material at a substantially constant pressure by moving of said collapsible diaphragm. The vapor-pressure driven pump system is useful for various situations, especially in a gravity-free environment in space exploration.
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Patent Agency Ranking
公开(公告)号：US20230070933A1
公开(公告)日：2023-03-09
申请号：US17447061
申请日：2021-09-07
Applicant: Purdue Research Foundation
Inventor： Steven M. Pugia , Anthony G. Cofer , Alina Alexeenko
IPC: B64G1/40
Abstract: A microthruster for controlling small spacecraft and methods for manufacturing the same are disclosed. Embodiments of the microthruster include one or more nozzle throats with cross sectional areas of at most 20 μm2, and some with 6 μm2. Some embodiments include heaters that heat water in one or more reservoirs to increase pressure in the reservoirs and eject the water from the one or more nozzle throats. Some embodiments are manufactured by etching channels into one or more layers of material, and still further embodiments are manufactured by forming the nozzle throats and/or the reservoirs between two layers of material. Some microthruster embodiments are flat in shape with the nozzle throats ejecting water out the thin sides of the microthruster. Still further embodiments are formed by etching channels into one layer of material, printing a heater onto another layer of material, and bonding the two layers together.
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公开(公告)号：US11592236B2
公开(公告)日：2023-02-28
申请号：US17526080
申请日：2021-11-15
Applicant: Purdue Research Foundation
Inventor： Mukerrem Cakmak , Alina Alexeenko
Abstract: Roll-to-roll freeze-drying (lyophilization) system and process for facilitating freeze-drying processes and enabling the collection of data by which a freeze-drying process can be monitored and evaluated. Such a system includes a roll-to-roll freeze-drying apparatus adapted to continuously freeze and dry a liquid to form a freeze-dried and encapsulate freeze-dried sheet portions of the freeze-dried sheet to create premeasured pouches containing the freeze-dried sheet portions. The system further includes a metrology section that monitors any of the freeze-dried sheet and the freeze-dried sheet portions during the freezing and drying of the liquid to generate data for controlling the freezing and drying of the liquid.
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公开(公告)号：US11506619B2
公开(公告)日：2022-11-22
申请号：US16233023
申请日：2018-12-26
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Andrew Strongrich
IPC: G01N25/00
Abstract: A microelectromechanical (MEMS) gas sensor operating based on Knudsen thermal force is disclosed. The sensor includes a substrate, at least one stationary assembly that is fixedly coupled to the substrate, and at least one moveable assembly that is positioned above the substrate which is biased to move substantially according to a main axis and juxtaposed with the at least one stationary assembly.
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公开(公告)号：US11243029B2
公开(公告)日：2022-02-08
申请号：US16859835
申请日：2020-04-27
Applicant: Purdue Research Foundation
Inventor： Andrew Strongrich , Alina Alexeenko
Abstract: A non-invasive method to monitor and control of lyophilization of a frozen product solution to remove solvents is disclosed which includes installing one or more wireless pressure sensors configured to fit into a lyophilization vial tray disposed in a lyophilization chamber having a plurality of product vials, wherein the wireless pressure are distributed among the product vials being lyophilized thereby providing spatial pressure variations, collecting the spatial pressure information from said wireless pressure sensors, calculating sublimation rate of the solution, and adjusting pressure and/or temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope.
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公开(公告)号：US10995879B2
公开(公告)日：2021-05-04
申请号：US15370633
申请日：2016-12-06
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Anthony George Cofer , Stephen Douglas Heister
Abstract: A microfabricated valve with no moving parts. In one embodiment, the valve includes a reservoir of a liquid that is in fluid communication with an outlet channel having a throat that is less than 100 microns wide. Preferably, the channel is an elongated slit. The configuration of channel is adapted and configured such that surface tension of the liquid prevents flow out of the channel. A heater increases the temperature of the meniscus of the fluid, until a portion of the fluid is ejected from the channel. The ejection of the fluid creates both a thrusting effect and a cooling effect.
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