-
公开(公告)号：US20220397346A1
公开(公告)日：2022-12-15
申请号：US17832372
申请日：2022-06-03
Applicant: Purdue Research Foundation , Genentech, Inc.
Inventor： Andrew Strongrich , Alina Alexeenko , Fredric John Lim , Lokesh Kumar
IPC: F26B5/06
Abstract: A lyophilization method for lyophilizing products inside one or more vials within a lyophilization chamber is disclosed which includes humidifying a charge gas to a predetermined relative humidity, cooling shelves in the lyophilization chamber to a predetermined temperature, pressurizing the chamber with the humidified charge gas to a pressurization threshold to thereby achieving a target relative humidity level within the lyophilization chamber, and suddenly releasing pressure within the lyophilization chamber until a depressurization threshold is reached in a short time interval up to about 4 seconds, during the depressurization, product inside one or more vials nucleate.
-
公开(公告)号：US20200340743A1
公开(公告)日：2020-10-29
申请号：US16859835
申请日：2020-04-27
Applicant: Purdue Research Foundation
Inventor： Andrew Strongrich , Alina Alexeenko
Abstract: A non-invasive method to monitor and control of lyophilization of a frozen product solution to remove solvents is disclosed which includes installing one or more wireless pressure sensors configured to fit into a lyophilization vial tray disposed in a lyophilization chamber having a plurality of product vials, wherein the wireless pressure are distributed among the product vials being lyophilized thereby providing spatial pressure variations, collecting the spatial pressure information from said wireless pressure sensors, calculating sublimation rate of the solution, and adjusting pressure and/or temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope.
-
公开(公告)号：US20230408195A1
公开(公告)日：2023-12-21
申请号：US18036067
申请日：2021-11-09
Applicant: Purdue Research Foundation
Inventor： Andrew Strongrich , Alina Alexeenko
Abstract: An environmental sensor system for monitoring nucleation in a lyophilization chamber is disclosed which includes a sensor unit, including a temperature sensor, a pressure sensor, and a reader circuit in electronic communication with the sensor unit; wherein the sensor unit is adapted to sealingly fit around a vial placed in a lyophilization chamber and further adapted to be energized by the reader circuit and provide signals associated with temperature and pressure within the vial in a non-invasive manner in which the sensors are configured to be positioned in a headspace within the vial but not in contact with product within the vial.
-
公开(公告)号：US20160363553A1
公开(公告)日：2016-12-15
申请号：US15183259
申请日：2016-06-15
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Andrew Strongrich
IPC: G01N27/22
CPC classification number: G01L9/00 , G01L21/26 , G01N27/226
Abstract: A microelectromechanical (MEMS) gas sensor operating based on Knudsen thermal force is disclosed. The sensor includes a substrate, at least one stationary assembly that is fixedly coupled to the substrate, and at least one moveable assembly that is positioned above the substrate which is biased to move substantially according to a main axis and juxtaposed with the at least one stationary assembly.
Abstract translation: 公开了基于Knudsen热力操作的微机电（MEMS）气体传感器。 所述传感器包括基底，固定地联接到所述基底的至少一个固定组件和位于所述基底上方的至少一个可移动组件，所述至少一个可移动组件被偏置以基本上沿着主轴线移动并且与所述至少一个固定 部件。
-
公开(公告)号：US11635256B2
公开(公告)日：2023-04-25
申请号：US17588929
申请日：2022-01-31
Applicant: Purdue Research Foundation
Inventor： Andrew Strongrich , Alina Alexeenko
Abstract: A system to monitor and control a lyophilization process using a wireless network is disclosed which includes one or more wireless pressure and gas temperature sensors adapted to provide pressure and gas temperature measurements of the ambient environment, a lyophilization chamber, wherein the one or more wireless pressure sensors are distributed in one or more lyophilization vial trays, a vacuum pump, adapted to change the pressure with the lyophilization chamber, a heat exchanger adapted to modify temperature within the lyophilization chamber, and a controller adapted to collect pressure and gas temperature data from the one or more wireless pressure and gas temperature sensors, calculate sublimation rate of a product to be lyophilized using the collected pressure and gas temperature data, and adjust one or both of pressure and temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope.
-
Patent Agency Ranking
公开(公告)号：US20220341859A9
公开(公告)日：2022-10-27
申请号：US16233023
申请日：2018-12-26
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Andrew Strongrich
IPC: G01N25/00
Abstract: A microelectromechanical (MEMS) gas sensor operating based on Knudsen thermal force is disclosed. The sensor includes a substrate, at least one stationary assembly that is fixedly coupled to the substrate, and at least one moveable assembly that is positioned above the substrate which is biased to move substantially according to a main axis and juxtaposed with the at least one stationary assembly.
-
公开(公告)号：US20220155010A1
公开(公告)日：2022-05-19
申请号：US17588929
申请日：2022-01-31
Applicant: Purdue Research Foundation
Inventor： Andrew Strongrich , Alina Alexeenko
Abstract: A system to monitor and control a lyophilization process using a wireless network is disclosed which includes one or more wireless pressure and gas temperature sensors adapted to provide pressure and gas temperature measurements of the ambient environment, a lyophilization chamber, wherein the one or more wireless pressure sensors are distributed in one or more lyophilization vial trays, a vacuum pump, adapted to change the pressure with the lyophilization chamber, a heat exchanger adapted to modify temperature within the lyophilization chamber, and a controller adapted to collect pressure and gas temperature data from the one or more wireless pressure and gas temperature sensors, calculate sublimation rate of a product to be lyophilized using the collected pressure and gas temperature data, and adjust one or both of pressure and temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope.
-
公开(公告)号：US11506619B2
公开(公告)日：2022-11-22
申请号：US16233023
申请日：2018-12-26
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Andrew Strongrich
IPC: G01N25/00
Abstract: A microelectromechanical (MEMS) gas sensor operating based on Knudsen thermal force is disclosed. The sensor includes a substrate, at least one stationary assembly that is fixedly coupled to the substrate, and at least one moveable assembly that is positioned above the substrate which is biased to move substantially according to a main axis and juxtaposed with the at least one stationary assembly.
-
公开(公告)号：US11243029B2
公开(公告)日：2022-02-08
申请号：US16859835
申请日：2020-04-27
Applicant: Purdue Research Foundation
Inventor： Andrew Strongrich , Alina Alexeenko
Abstract: A non-invasive method to monitor and control of lyophilization of a frozen product solution to remove solvents is disclosed which includes installing one or more wireless pressure sensors configured to fit into a lyophilization vial tray disposed in a lyophilization chamber having a plurality of product vials, wherein the wireless pressure are distributed among the product vials being lyophilized thereby providing spatial pressure variations, collecting the spatial pressure information from said wireless pressure sensors, calculating sublimation rate of the solution, and adjusting pressure and/or temperature within the lyophilization chamber such that the calculated sublimation rate stays within a predetermined envelope.
-
公开(公告)号：US20200209174A1
公开(公告)日：2020-07-02
申请号：US16233023
申请日：2018-12-26
Applicant: Purdue Research Foundation
Inventor： Alina Alexeenko , Andrew Strongrich
IPC: G01N25/00
Abstract: A microelectromechanical (MEMS) gas sensor operating based on Knudsen thermal force is disclosed. The sensor includes a substrate, at least one stationary assembly that is fixedly coupled to the substrate, and at least one moveable assembly that is positioned above the substrate which is biased to move substantially according to a main axis and juxtaposed with the at least one stationary assembly.
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.016 seconds)
