公开(公告)号：US20250027032A1

公开(公告)日：2025-01-23

申请号：US18775747

申请日：2024-07-17

Applicant: Repligen Corporation

Inventor： Michael Bransby ,  Philip Yuen ,  Westley Blacklock ,  Marlon Tannous ,  Karol Lacki ,  Anthony Hunt ,  James Peyser

IPC: C12M1/00

Abstract: The invention provides tangential flow filtration systems and methods for capture and harvest of a biologic product, and related compositions.

公开(公告)号：US20230098953A1

公开(公告)日：2023-03-30

申请号：US17936426

申请日：2022-09-29

Applicant: Repligen Corporation

Inventor： James Peyser ,  Michael Bransby ,  Philip Yuen

IPC: C12M1/00 ,  G01N15/08

Abstract: A filter screening tool, system, and method allowing high throughput screening of filters (such as hollow fiber filters), such as for use in bioprocessing workflows. Feed material may be fed through different filter modules to assess, measure, analyze, determine, evaluate, teste, compare, screen, etc., properties or characteristics, etc., of filters within the filter modules. Each filter module may house a different type (e.g., material or configuration) of filter so that different filters may be compared and screened, such as for a selected use.

公开(公告)号：US20220251493A1

公开(公告)日：2022-08-11

申请号：US17729022

申请日：2022-04-26

Applicant: Repligen Corporation

Inventor： Michael Bransby ,  Philip Yuen

IPC: C12M1/00 ,  C12M1/26 ,  B01D61/18 ,  B01D61/14

Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.

公开(公告)号：US20210047605A1

公开(公告)日：2021-02-18

申请号：US16992698

申请日：2020-08-13

Applicant: Repligen Corporation

Inventor： Derek Carroll ,  Michael Bransby ,  Philip Yuen

IPC: C12M1/36 ,  G16B5/00 ,  B01D61/22 ,  B01D61/20 ,  C12M1/00

Abstract: The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing applications, systems employing such filters, and methods of filtration using the same.

公开(公告)号：US20190127678A1

公开(公告)日：2019-05-02

申请号：US16171867

申请日：2018-10-26

Applicant: Repligen Corporation

Inventor： Michael Bransby ,  Philip Yuen

IPC: C12M1/00 ,  C12M1/26 ,  B01D61/14 ,  B01D61/18

Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.