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公开(公告)号：US20240133788A1
公开(公告)日：2024-04-25
申请号：US18535389
申请日：2023-12-11
CPC分类号： G01N15/0612 , B01D61/20 , B01D71/02 , B01D71/0215 , B01D2311/103 , G01N2015/0681 , G01N15/075
摘要： A device, system and method for the detection and screening of plastic microparticles in a sample is disclosed. A nanoporous silicon nitride membrane is used to entrap plastic microparticles contained in the sample. The sample may be a water sample, an air sample, or other liquid or gas sample. The entrapped plastic microparticles are then heated or otherwise processed on the nanoporous silicon nitride membrane. An imaging system observes the nanoporous silicon nitride membrane with the entrapped plastic microparticles to determine the type and quantity of the various plastic microparticles that are entrapped on the membrane.
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公开(公告)号：US20240100482A1
公开(公告)日：2024-03-28
申请号：US18530997
申请日：2023-12-06
申请人： FUJIFILM Corporation
CPC分类号： B01D61/18 , B01D61/20 , B01D71/261 , B01D71/262 , B01D71/56 , B01D71/641 , B01D69/02
摘要： A filtering device is for obtaining a chemical liquid by purifying a liquid to be purified, and the filtering device has an inlet portion, an outlet portion, a filter A, at least one filter B different from the filter A, and a flow path which includes the filter A and the filter B arranged in series and extends from the inlet portion to the outlet portion, in which the filter A is a porous membrane containing a polyimide-based resin.
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公开(公告)号：US11925904B2
公开(公告)日：2024-03-12
申请号：US16328502
申请日：2017-10-05
CPC分类号： B01D63/087 , B01D61/18 , B01D61/20 , B01D2201/204
摘要： A funnel-less filtration device that attaches directly to a storage container such as a cell culture media bottle. The device includes a filter collar containing one or more membranes, an inlet with a coupling device for attaching the filter device to a supply of liquid to be filtered, an outlet at a lower portion of the collar, a vacuum port in the collar below the membrane(s) and a filtered vent in the collar above the membrane(s). Optionally, the device may include a filtrate reservoir attached to the outlet, preferably by a threaded connection. Optionally, the upper opening to the filter collar is selectively and removably sealed with a lid until used. The lid is then removed the filter device inverted over a storage container such as cell culture media bottle and the two are attached via the upper opening of the filter collar. The assembly is then inverted so the supply container is above the filter device. Upon subjecting the sample in the bottle to a driving force such as vacuum, the sample flows through the filtration element, and into a filtrate reservoir below the outlet of the filter collar.
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公开(公告)号：US20230285972A1
公开(公告)日：2023-09-14
申请号：US18014010
申请日：2021-06-22
发明人： Kyusang LEE , Hee Chul Park , Ju Young CHOI , Yoon Kyoung CHO
CPC分类号： B01L3/502761 , B01D61/147 , B01D61/20 , B01D63/087 , B01D71/50 , B01L2200/0652 , B01L2300/0654 , B01L2300/0681 , B01L2300/168
摘要： A particle filtration device according to an embodiment of the present invention as a particle filtration device of a lab-on-disk of a rotation type includes: a filtration film that separates particles by filtering a sample; a main chamber connected to the inlet surface of the filtration film and supplying the sample to the inlet surface of the filtration film; an outlet chamber that is connected to the outlet surface of the filtration film and accommodates the filtration fluid from which particles are separated while passing through the filtration film; and a waste fluid chamber connected to the outlet chamber and storing the filtration fluid, wherein the particle filtration device includes a first flow path that connects between the outlet chamber and the waste fluid chamber, and a second flow path that connects between the outlet chamber and the waste fluid chamber but is positioned farther from the center of the lab-on-disk than the first flow path.
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公开(公告)号：US11712659B2
公开(公告)日：2023-08-01
申请号：US16764440
申请日：2018-10-11
发明人： Thomas Loewe , Bernhard Diel , Maik Sommer
CPC分类号： B01D61/22 , B01D29/601 , B01D29/605 , B01D29/606 , B01D36/001 , B01D61/18 , B01D61/20 , B01D65/02 , B01D2311/14 , B01D2311/18 , B01D2313/58 , B01D2317/04
摘要： A method of filtering a large volume of a medium using a pre-sterilizable, at least partially automated single-use filtration device which includes an unfiltrate inlet, a filtrate outlet, a main line running between the unfiltrate inlet and the filtrate outlet, filter elements arranged in the main line, a venting line and sensors for detecting specific process parameters and regulating means for adjusting specific process parameters, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprises the following process steps: a) filling the single-use filtration device with medium with low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements; e) filtering the medium by means of the filter elements; f) re-rinsing with high flow; and g) closing the main line; wherein the process steps f) and g) are optional.
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公开(公告)号：US11578302B2
公开(公告)日：2023-02-14
申请号：US17752231
申请日：2022-05-24
申请人： Repligen Corporation
发明人： Rudolf Pavlik
IPC分类号： F04B49/20 , F04B43/00 , B01D61/22 , B01D61/58 , B01D63/02 , B01D61/20 , F04B23/02 , C12M1/36 , C12M1/34 , F04B23/04 , C12M1/00 , F04B43/073 , F04B49/06
摘要： A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.
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公开(公告)号：US11578301B2
公开(公告)日：2023-02-14
申请号：US16908225
申请日：2020-06-22
申请人： Repligen Corporation
发明人： Rudolf Pavlik
IPC分类号： B01D61/22 , F04B49/20 , F04B23/04 , F04B43/00 , B01D61/58 , B01D63/02 , B01D61/20 , C12M1/36 , C12M1/34 , C12M1/00 , F04B43/073 , F04B49/06 , F04B23/02
摘要： A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.
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公开(公告)号：US11555174B2
公开(公告)日：2023-01-17
申请号：US17828353
申请日：2022-05-31
申请人： REPLIGEN CORPORATION
发明人： David Serway
摘要： A method for promoting biological activity uses a filter system to increase cell production of a fed batch bioreactor. The filter system cycles bioreactor fluid through a hollow fiber tangential flow filter which separates metabolic wastes (as well as proteins) from cells produced in bioreactor and returned to fed batch bioreactor, improving cell production in the fed batch bioreactor. The filter system includes a disposable pump and filter, and a reusable control system. The pump is a low shear gamma stable pump gently cycling bioreactor fluid through the filter with minimal damage to the cells produced in the bioreactor. The pumphead and hollow fiber tangential flow filter are disposable. The pump motor is part of the control system and is reusable. The pumphead and filter are provided as an assembled and pre-sterilized unit allowing simple and quick attachment to the fed batch bioreactor, and simple and quick disposal.
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公开(公告)号：US20220347630A1
公开(公告)日：2022-11-03
申请号：US17766069
申请日：2020-10-08
申请人： STOBBE GMBH
发明人： Per STOBBE
摘要： The invention concerns a set of tubular elastic coupling bodies arranged opposing at inlet and outlet of a filter cartridge.
The tubular elastic end coupling, comprises a tube end adapted to fit on the filter cartridge inlet/outlet. The elastic end coupling comprises one or more tubular fluid connections for conveying fluid to and from external means for fluid content separation purposes by said membrane filter cartridge.-
公开(公告)号：US11439739B2
公开(公告)日：2022-09-13
申请号：US16935992
申请日：2020-07-22
摘要： The present invention relates to a cytopheretic cartridge for use in treating and/or preventing inflammatory conditions that affect myocardial function and to related methods. The cartridge can be used in treating a subject with myocardial dysfunction, such as a subject with chronic heart failure and/or acute decompensated heart failure.
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