公开(公告)号：US20190100603A1

公开(公告)日：2019-04-04

申请号：US16157951

申请日：2018-10-11

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Weihsien HO ,  Jaume PONS ,  Arvind RAJPAL ,  Pavel STROP

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

公开(公告)号：US20170058054A1

公开(公告)日：2017-03-02

申请号：US15351275

申请日：2016-11-14

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Weihsien HO ,  Jaume PONS ,  Arvind RAJPAL ,  Pavel STROP

IPC: C07K16/46 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/283 ,  C07K16/2887 ,  C07K16/30 ,  C07K16/46 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglubulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

Abstract translation: 本发明涉及工程化的异源多聚体蛋白质，更具体地，涉及用于产生和纯化异二聚体蛋白质的方法，例如双特异性抗体和包含免疫球蛋白样铰链序列的其它异二聚体蛋白质。 还提供了用于生产和纯化这些工程异二聚体蛋白的方法及其在诊断和治疗中的应用。

公开(公告)号：US20160152698A1

公开(公告)日：2016-06-02

申请号：US14940710

申请日：2015-11-13

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Jaume PONS ,  Arnon ROSENTHAL

IPC: C07K16/22

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

公开(公告)号：US20160096884A1

公开(公告)日：2016-04-07

申请号：US14966175

申请日：2015-12-11

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Arnon ROSENTHAL ,  Jaume PONS ,  Wei-Hsien HO

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

Abstract: Antibodies directed to the C-terminal side of β-amyloid peptide and methods of using these antibodies for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described.

Abstract translation: 针对β-淀粉样蛋白肽的C-末端的抗体以及使用这些抗体诊断和治疗阿尔茨海默病和A＆bgr的方法; 描述了肽相关疾病。