公开(公告)号：US08378305B2

公开(公告)日：2013-02-19

申请号：US12935302

申请日：2009-03-20

申请人： Daniel Gagnon ,  Douglas B. McKnight

发明人： Daniel Gagnon ,  Douglas B. McKnight

IPC分类号： G01T1/20

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01R33/481

摘要： When performing positron emission tomography (PET) scanning and image reconstruction, a primary PET system (10) with a primary PET detector array (12) is used to image a patient or subject, and a secondary PET detector array (14) is coupled to the system at specific input points to mitigate unnecessary duplication of system components. The primary system (10) provides PET data processing and reconstruction for the secondary array (14), in addition to the first array (12). An adjustable array (120) includes radially movable detectors (122) and stationary detectors (124) with different crystal resolutions. The movable detectors (122) are alternately positioned with the stationary detectors (124) at a first radius to form a large detector ring, or are positioned at a second, smaller radius without the stationary detectors (124) to form a small detector ring.

摘要翻译： 当进行正电子发射断层扫描（PET）扫描和图像重建时，使用具有主要PET检测器阵列（12）的主要PET系统（10）对患者或受试者进行成像，并且将辅助PET检测器阵列（14）耦合到 该系统在特定的输入点，以减轻不必要的系统组件重复。 除了第一阵列（12）之外，主系统（10）还为次级阵列（14）提供PET数据处理和重建。 可调节阵列（120）包括具有不同晶体分辨率的径向可移动探测器（122）和固定探测器（124）。 移动检测器（122）与第一半径处的固定式检测器（124）交替定位以形成大的检测器环，或者定位在第二较小的半径处，而没有固定的检测器（124）以形成小的检测器环。

公开(公告)号：US08324580B1

公开(公告)日：2012-12-04

申请号：US13153611

申请日：2011-06-06

申请人： Daniel Gagnon ,  Kent Burr

发明人： Daniel Gagnon ,  Kent Burr

IPC分类号： G01T1/161

CPC分类号： G01T1/1647

摘要： A digital photosensor that includes a photomultiplier tube (PMT) including a power distribution circuit, the PMT outputting an analog signal in response to received light; an analog-to-digital converter (ADC) to receive the analog signal and to generate a digital signal; and a non-transitory memory storing manufacturing parameters of the PMT and operational parameters of the PMT, the operational parameters being calculated by a parameter calculation unit during operation of the PMT, wherein the PMT, the ADC, and the memory are integrated into a single housing.

摘要翻译： 一种数字光电传感器，包括具有功率分配电路的光电倍增管（PMT），所述PMT响应于所接收的光而输出模拟信号; 模数转换器（ADC），用于接收模拟信号并产生数字信号; 以及存储PMT的制造参数和PMT的运行参数的非暂时性存储器，所述运行参数由PMT运转中的参数运算单元计算，其中所述PMT，所述ADC和所述存储器被集成为单个 住房。

公开(公告)号：US08304738B2

公开(公告)日：2012-11-06

申请号：US12907124

申请日：2010-10-19

申请人： Daniel Gagnon ,  Kent Burr

发明人： Daniel Gagnon ,  Kent Burr

IPC分类号： G01T1/20

CPC分类号： G01T1/1644 ,  G01T1/2006 ,  G01T1/2018 ,  G02B6/06 ,  G02B6/08

摘要： A positron emission tomography scanner system that includes detector modules arranged adjacent to one another to form a cylindrical detector ring. Each of the detector modules includes an array of scintillation crystal elements, a plurality of photosensors arranged to cover the array of crystal elements and configured to receive light emitted from the array of crystal elements, and a fiber optics plate arranged between the array of scintillation crystal elements and the plurality of photosensors, the fiber optics plate including a plurality of fibers configured to guide the light emitted from the scintillation crystal to the plurality of photosensors.

摘要翻译： 正电子发射断层摄影扫描仪系统，其包括彼此相邻布置以形成圆柱形检测器环的检测器模块。 每个检测器模块包括闪烁晶体元件阵列，多个光电传感器布置成覆盖晶体元件阵列并被配置为接收从晶体元件阵列发射的光，以及布置在闪烁晶体阵列之间的光纤板 元件和多个光电传感器，所述光纤板包括被配置为将从闪烁晶体发射的光引导到多个光电传感器的多个光纤。

公开(公告)号：US08304736B2

公开(公告)日：2012-11-06

申请号：US13120659

申请日：2009-10-05

申请人： Daniel Gagnon

发明人： Daniel Gagnon

IPC分类号： G01T1/10

CPC分类号： G01T1/2018 ,  Y10T29/49002

摘要： When employing hygroscopic scintillation crystals (32) in a nuclear detector (e.g., PET or SPECT), Silicon photo-multiplier (SiPM) sensors (34) are coupled to each scintillation crystal (32) to improve scintillation event detection and reduce scatter. The crystals (32) and sensors (34) are hermetically sealed in a detector housing (50) using a sealant layer (51). Electrical contacts (60) from each sensor (34) extend through the sealant layer (51) or are bused together such that the bus extends through the sealant layer (51). In this manner, hygroscopic scintillation crystals (e.g., LaBr, NaI, etc.) are protected from humidity and light scatter is reduced by direct coupling of the sensors (34) and crystals (32).

摘要翻译： 当在核检测器（例如PET或SPECT）中使用吸湿闪烁晶体（32）时，硅光电倍增器（SiPM）传感器（34）耦合到每个闪烁晶体（32），以改善闪烁事件检测并减少散射。 晶体（32）和传感器（34）使用密封剂层（51）气密地密封在检测器壳体（50）中。 来自每个传感器（34）的电触头（60）延伸穿过密封剂层（51），或者被连接在一起，使得总线延伸穿过密封剂层（51）。 以这种方式，吸湿性闪烁晶体（例如LaBr，NaI等）被保护免受湿度，并且通过传感器（34）和晶体（32）的直接耦合来减少光散射。

公开(公告)号：US08063376B2

公开(公告)日：2011-11-22

申请号：US12535722

申请日：2009-08-05

申请人： Piotr J. Maniawski ,  Daniel Gagnon

发明人： Piotr J. Maniawski ,  Daniel Gagnon

IPC分类号： G01T1/161

CPC分类号： A61N5/103 ,  A61B6/032 ,  A61B6/037 ,  A61B6/5235 ,  A61N5/1039 ,  A61N2005/1052 ,  A61N2005/1061 ,  G01T1/2985

摘要： An imaging system comprises: a ring of positron emission tomography (PET) detectors; a PET housing at least partially surrounding the ring of PET detectors and defining a patient aperture of at least 80 cm; a coincidence detection processor or circuitry configured to identify substantially simultaneous 511 keV radiation detection events corresponding to electron-positron annihilation events; and a PET reconstruction processor configured to reconstruct into a PET image the identified substantially simultaneous 511 keV radiation detection events based on lines of response defined by the substantially simultaneous 511 keV radiation detection events. Radiation planning utilizing such an imaging system comprises: acquiring PET imaging data for a human subject arranged in a radiation therapy position requiring a patient aperture of at least about 80 cm; reconstructing said imaging data into a PET image encompassing an anatomical region to undergo radiation therapy; and generating a radiation therapy plan based on at least the PET image.

摘要翻译： 成像系统包括：正电子发射断层摄影（PET）检测器环; PET壳体，其至少部分地围绕PET检测器的环并限定至少80cm的患者孔; 符合检测处理器或电路，被配置为基本上同时识别对应于电子 - 正电子湮灭事件的511keV辐射检测事件; 以及PET重建处理器，其被配置为基于由基本上同时的511keV辐射检测事件限定的响应线，将所识别的基本上同时的511keV辐射检测事件重建成PET图像。 利用这种成像系统的辐射规划包括：获取布置在放射治疗位置的人类对象的PET成像数据，其需要至少约80cm的患者孔径; 将所述成像数据重建成包含解剖区域的PET图像进行放射治疗; 以及至少基于PET图像生成放射治疗计划。

公开(公告)号：US20100188217A1

公开(公告)日：2010-07-29

申请号：US12646586

申请日：2009-12-23

申请人： Daniel Gagnon ,  Paul Lukas ,  Robert Baker

发明人： Daniel Gagnon ,  Paul Lukas ,  Robert Baker

IPC分类号： G08B13/00

CPC分类号： H05B37/0227 ,  F21V23/0442 ,  Y02B20/44

摘要： Disclosed is a triple-sensor motion detector for illuminating the approach to a display case or other object. The triple-sensor motion detector provides a field of detection that spans the front width of the case, yet does not include the areas along the sides of the case. The detector reduces inadvertent triggering of the illumination by persons approaching the side of the case or approaching another case on the other side of an aisle.

摘要翻译： 公开了一种三重传感器运动检测器，用于照明到展示柜或其他物体的方法。 三重传感器运动检测器提供跨越壳体前部宽度的检测领域，但不包括沿壳体侧面的区域。 检测器减少人员接近壳体侧面或靠近通道另一侧的人的照明的无意触发。

公开(公告)号：US07365335B2

公开(公告)日：2008-04-29

申请号：US11464534

申请日：2006-08-15

申请人： Daniel Gagnon ,  Joel Karp ,  Lucretiu M. Popescu

发明人： Daniel Gagnon ,  Joel Karp ,  Lucretiu M. Popescu

IPC分类号： G01T1/166

CPC分类号： G01T1/2985 ,  G06T11/006

摘要： A PET system includes an improved image reconstruction algorithm based on an improved modeling of the point-spread function. PET time of flight data is used to obtain a mean emitting point and a time of flight probability function. This information is then used to model the point-spread function. The time of flight probability function and the detector response function are used to define a probability volume for a given line of response, which is then used in the reconstruction of the image.

摘要翻译： PET系统包括基于点扩散函数的改进建模的改进的图像重建算法。 PET飞行时间数据用于获得平均发射点和飞行时间概率函数。 然后将该信息用于对点扩散函数进行建模。 飞行时间概率函数和检测器响应函数用于定义给定响应线的概率体积，然后将其用于图像的重建。

公开(公告)号：US20060124855A1

公开(公告)日：2006-06-15

申请号：US10541559

申请日：2003-12-19

申请人： Daniel Gagnon

发明人： Daniel Gagnon

IPC分类号： G01T1/24

CPC分类号： A61B6/037 ,  A61B6/032 ,  A61B6/5235 ,  G01T1/1603 ,  G01T1/1611 ,  G01T1/1644 ,  G01T1/1648 ,  G01T1/2985

摘要： A nuclear camera (10) includes four or more gamma detectors (20, 20′, 20″, 201, 202, 203, 204, 205, 206) arranged or, a generally circular rotatable gantry (12, 12′, 12″, 12′″) around an imaging region that emits emission radiation. The gamma detectors are each disposed at a fixed equal distance (R, R2, R3, R5) from an imaging isocenter (22, 22′, 22′, 22″) to rotate in a fixed radius circular orbit. Each gamma detector includes a radiation sensitive surface (72) that responds to the emission radiation and a slat collimator (70) that spins about an axis 88. Resolution and sensitivity at the fixed radius are selected by selecting collimator slat height (Wz) and spacing (G) and radiation sensitive surface width (Cy). The gamma detectors and rotating gantry are enclosed in an optically opaque toroidal housing (14) that defines a generally circular bore (16) that admits imaging subjects over a range of sizes.

摘要翻译： 核相机（10）包括布置的四个或更多个伽马检测器（20,20'，20“，201,202,203,204,205,206），或者大致圆形的可旋转机架（12,12'，12' '，12“'）围绕发射发射辐射的成像区域。 γ检测器各自以成像等角点（22,22'，22'，22“）以固定的相等距离​​（R，R 2，R 3，R 5）设置，以固定的半径圆形轨道旋转。 每个伽马检测器包括响应于发射辐射的辐射敏感表面（72）和围绕轴线88旋转的平板准直器（70）。通过选择准直器板条高度（Wz）和间距来选择固定半径处的分辨率和灵敏度 （G）和辐射敏感表面宽度（Cy）。 伽马探测器和旋转机架被封闭在光学不透明的环形壳体（14）中，该环形壳体限定大致圆形的孔（16），其允许成像对象在一定尺寸范围内。

公开(公告)号：US06310968B1

公开(公告)日：2001-10-30

申请号：US09198787

申请日：1998-11-24

申请人： William G. Hawkins ,  Daniel Gagnon

发明人： William G. Hawkins ,  Daniel Gagnon

IPC分类号： G06K900

CPC分类号： G01T1/1615 ,  A61B6/037 ,  G01T1/2985

摘要： A method of ML-EM image reconstruction is provided for use in connection with a diagnostic imaging apparatus (10) that generates projection data. The method includes collecting projection data, including measured emission projection data. An initial emission map and attenuation map are assumed. The emission map and the attenuation map are iteratively updated. With each iteration, the emission map is recalculated by taking a previous emission map and adjusting it based upon: (i) the measured emission projection data; (ii) a reprojection of the previous emission map which is carried out with a multi-dimensional projection model; and, (iii) a reprojection of the attenuation map. As well, with each iteration, the attenuation map is recalculated by taking a previous attenuation map and adjusting it based upon: (i) the measured emission projection data; and, (ii) a reprojection of the previous emission map which is carried out with the multi-dimensional projection model. In a preferred embodiment, with source-assisted reconstruction, the recalculation of the attenuation map is additionally based upon: (iii) measured transmission projection data; and, (iv) a reference or blank data set of measured transmission projection data taken without the subject present in the imaging apparatus (10).

摘要翻译： 提供了一种ML-EM图像重建方法，用于与产生投影数据的诊断成像设备（10）相结合。 该方法包括收集投影数据，包括测量的发射投影数据。 假设初始发射图和衰减图。 发射图和衰减图迭代更新。 通过每次迭代，通过采取先前的发射图并根据以下进行调整来重新计算发射图：（i）测量的发射投影数据; （ii）用多维投影模型进行的先前发射图的重新投影; 和（iii）衰减图的重新投射。 同样地，通过每次迭代，通过采取先前的衰减图并且基于以下来调整衰减图来重新计算衰减图：（i）测量的发射投影数据; 和（ii）用多维投影模型进行的先前发射图的重新投射。 在优选实施例中，通过源辅助重建，衰减映射的重新计算另外基于：（iii）测量的传输投影数据; 以及（iv）在成像装置（10）中没有被摄体存在的测量的透射投影数据的参考或空白数据集。

公开(公告)号：US06171243B2

公开(公告)日：2001-01-09

申请号：US08865923

申请日：1997-05-30

申请人： Daniel Gagnon ,  Frank P. DiFilippo

发明人： Daniel Gagnon ,  Frank P. DiFilippo

IPC分类号： A61B500

CPC分类号： G01T1/1615 ,  A61B6/037 ,  G01T1/1648 ,  G01T1/172 ,  G01T1/2985

摘要： A diagnostic imaging system includes oppositely disposed radiation detectors (32, 34) configured to detect coincidence radiation events caused by a substance injected into a subject which generates positron emissions. A coincidence data processor (40) collects and processes the radiation detected by the detectors (32, 34) and a coincidence circuitry (44) matches and compares the detected events to determine coincidence. Coincidence data is generated and stored in a coincidence data memory (46). A collimated radiation detector (50) is disposed at an angle to the coincidence radiation detectors (32, 34) and is configured to detect single photon radiation traveling along a selected projection path determined by a collimator (52) mounted on a front face of the collimated radiation detector (50). A single photon data processor (60) generates collimated data (74) based on the radiation detected by the collimated radiation detector (50). A combiner (80) selectively combines the coincidence data (46) and the collimated data (74) and the combined data is reconstructed into an image representation (84) of a region of interest.

摘要翻译： 诊断成像系统包括相对设置的辐射检测器（32,34），其被配置为检测由注入到被摄体中的物质引起的重合辐射事件，其产生正电子发射。 符合数据处理器（40）收集并处理由检测器（32,34）检测到的辐射，并且重合电路（44）匹配并比较检测到的事件以确定一致性。 生成一致数据并存储在重合数据存储器（46）中。 准直辐射检测器（50）以与重合辐射检测器（32,34）成一角度的方式设置，并且被配置为检测沿着安装在所述第一辐射检测器的正面上的准直器（52）确定的所选投影路径行进的单光子辐射 准直辐射探测器（50）。 单光子数据处理器（60）基于由准直辐射检测器（50）检测的辐射产生准直数据（74）。 组合器（80）选择性地组合符合数据（46）和准直数据（74），并且组合数据被重构成感兴趣区域的图像表示（84）。