公开(公告)号：US20190183437A1

公开(公告)日：2019-06-20

申请号：US16227845

申请日：2018-12-20

申请人： UNIVERSITY HEALTH NETWORK

发明人： Edward TAYLOR ,  David A. JAFFRAY ,  Ivan Wai Tong YEUNG

IPC分类号： A61B6/03 ,  G16H30/40 ,  A61B6/00 ,  A61B5/055 ,  G01T1/161 ,  A61K49/00

CPC分类号： A61B6/037 ,  A61B5/055 ,  A61B6/481 ,  A61B6/5235 ,  A61K49/0002 ,  G01T1/1611 ,  G01T1/2985 ,  G06T2207/30096 ,  G16H30/40

摘要： Uptake of hypoxia-sensitive PET tracers is dependent on tissue transport properties, specifically, distribution volume. Variability in tissue transport properties reduces the sensitivity of static PET imaging to hypoxia. When tissue transport (vd) effects are substantial, correlations between the two methods of determining hypoxic fractions are greatly reduced—that is, trapping rates k3 are only modestly correlated with tumour-to-blood ratio (TBR). In other words, the usefulness of dynamic- and static-PET based hypoxia surrogates, trapping rate k3 and TBR, in determining hypoxic fractions is reduced in regions where diffusive equilibrium is achieved slowly. A process is provided for quantifying hypoxic fractions using a novel biomarker for hypoxia, hypoxia-sensitive tracer binding rate kb, based on PET imaging data. The same formalism can be applied to model the kinetics of non-binding CT and MT contrast agents, giving histopathological information about the imaged tissue.

公开(公告)号：US20180136340A1

公开(公告)日：2018-05-17

申请号：US15699458

申请日：2017-09-08

申请人： Minnesota Imaging and Engineering LLC

发明人： Robert Sigurd Nelson ,  William Bert Nelson

IPC分类号： G01T1/164 ,  G01T1/20 ,  G01T1/24 ,  A61B6/00 ,  G01T1/161

CPC分类号： G01T1/1644 ,  A61B6/4028 ,  A61B6/4233 ,  A61B6/4241 ,  G01T1/1611 ,  G01T1/2002 ,  G01T1/247

摘要： Detector module designs for radiographic imaging include first and second layers of scintillator rods or pixel arrays oriented in first and second directions. The first and second directions are transversely oriented to define a light sharing region between the first and second layers. Encoding features may be disposed in, on or between the first and second layers, and configured to modulate propagation of optical signals therealong or therebetween.

公开(公告)号：US20150335301A1

公开(公告)日：2015-11-26

申请号：US14818430

申请日：2015-08-05

申请人： General Electric Company

发明人： Nathan Hermony

IPC分类号： A61B6/00 ,  A61B6/03 ,  G01T1/29 ,  G01T1/161 ,  G01T1/164

CPC分类号： A61B6/4258 ,  A61B6/032 ,  A61B6/037 ,  A61B6/4266 ,  A61B6/4417 ,  A61B6/4429 ,  A61B6/503 ,  A61B6/5235 ,  G01T1/1603 ,  G01T1/1611 ,  G01T1/1614 ,  G01T1/1642 ,  G01T1/2985

摘要： A diagnostic imaging system and method using multiple types of imaging detectors are provided. The imaging system includes a gantry having a rotor and a stator and a pair of gamma detectors coupled to the rotor. The imaging system further includes a gamma detector coupled to the stator, The gamma detector coupled to the stator is different than the pair of gamma detectors coupled to the rotor.

摘要翻译： 提供了使用多种成像检测器的诊断成像系统和方法。 成像系统包括具有转子和定子以及耦合到转子的一对γ检测器的台架。 成像系统还包括耦合到定子的伽马检测器。耦合到定子的伽马检测器不同于耦合到转子的一对伽马检测器。

公开(公告)号：US20150323685A1

公开(公告)日：2015-11-12

申请号：US14804799

申请日：2015-07-21

申请人： MINNESOTA IMAGING AND ENGINEERING

发明人： Robert Sigurd Nelson ,  William Bert Nelson

IPC分类号： G01T1/24 ,  G01T1/161

CPC分类号： G01T1/242 ,  G01T1/1611 ,  G01T1/1614

摘要： Detector designs and systems for enhanced radiographic imaging with integrated detector systems incorporate one or more of Compton and nuclear medicine imaging, PET imaging and x-ray CT imaging capabilities. Detector designs employ one or more layers of detector modules comprised of edge-on or face-on detectors or a combination of edge-on and face-on detectors which may employ gas, scintillator, semiconductor, low temperature (such as Ge and superconductor) and structured detectors. Detectors may implement tracking capabilities and may operate in a non-coincidence or coincidence detection mode.

摘要翻译： 用于具有集成检测器系统的增强射线照相成像的检测器设计和系统包括康普顿和核医学成像，PET成像和X射线CT成像功能中的一种或多种。 检测器设计采用一个或多个检测器模块，这些检测器模块包括边缘检测器或正面检测器，或者可以使用气体，闪烁体，半导体，低温（例如Ge和超导体）的边缘检测器和正面检测器的组合， 和结构化检测器。 检测器可以实现跟踪能力并且可以以不一致或重合检测模式操作。

公开(公告)号：US08748827B2

公开(公告)日：2014-06-10

申请号：US13947198

申请日：2013-07-22

申请人： Biosensors International Group, Ltd.

发明人： Yoel Zilberstein ,  Nathaniel Roth ,  Benny Rousso ,  Shlomo Ben-Haim

IPC分类号： G01T1/166

CPC分类号： A61B6/42 ,  A61B6/037 ,  A61B6/04 ,  A61B6/4258 ,  A61B6/4266 ,  A61B6/507 ,  G01T1/1611 ,  G01T1/1635 ,  G01T1/1644 ,  G21K1/02

摘要： A system of performing a volumetric scan. The system comprises a surface of positioning a patient in a space parallel thereto, a plurality of extendable detector arms each the detector arm having a detection unit having at least one radiation detector, and an actuator which moves the detection unit along a linear path, and a gantry which supports the plurality of extendable detector arms around the surface so that each the linear path of each respective the extendable detector arm being directed toward the space.

摘要翻译： 执行体积扫描的系统。 该系统包括将患者定位在与其平行的空间中的表面，多个可延伸的检测臂，每个检测器臂具有检测单元，该检测单元具有至少一个辐射检测器，以及致动器，沿着线性路径移动检测单元， 所述台架支撑在所述表面周围的所述多个可延伸的检测器臂，使得每个相应的所述可延伸的检测器臂的每条线性路径都朝向所述空间。

公开(公告)号：US08520797B2

公开(公告)日：2013-08-27

申请号：US13152818

申请日：2011-06-03

申请人： Yasunobu Yamada

发明人： Yasunobu Yamada

IPC分类号： G01N23/00

CPC分类号： G01T1/1648 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/483 ,  A61B6/583 ,  A61B6/586 ,  G01T1/1611

摘要： A medical imaging apparatus includes an X-ray imaging apparatus; and a nuclear medicine imaging apparatus. The X-ray imaging apparatus includes an X-ray tube configured to emit X-rays for generating an X-ray CT image. The nuclear medicine imaging apparatus includes a detector configured to detect radiation for generating a nuclear medicine image. At least one of the X-ray imaging apparatus and the nuclear medicine imaging apparatus includes a determining unit configured to determine whether the detector detects the X-rays emitted by the X-ray tube, thereby determining whether there is a failure in the detector.

摘要翻译： 医疗成像装置包括X射线成像装置; 和核医学成像装置。 X射线成像装置包括：X射线管，被配置为发射X射线以产生X射线CT图像。 核医学成像装置包括：检测器，被配置为检测辐射以产生核医学图像。 X射线成像装置和核医学成像装置中的至少一个包括确定单元，其被配置为确定检测器是否检测到由X射线管发射的X射线，从而确定检测器中是否存在故障。

公开(公告)号：US08260013B2

公开(公告)日：2012-09-04

申请号：US11719781

申请日：2005-11-04

申请人： Vladimir Pekar ,  Michael Kaus ,  Ingwer C. Carlsen ,  Todd R. McNutt ,  R. Keith Tipton

发明人： Vladimir Pekar ,  Michael Kaus ,  Ingwer C. Carlsen ,  Todd R. McNutt ,  R. Keith Tipton

IPC分类号： G06K9/00

CPC分类号： A61B6/032 ,  A61B6/4417 ,  A61B6/5235 ,  A61B8/13 ,  A61B8/4416 ,  A61N5/103 ,  A61N5/1039 ,  G01T1/1611 ,  G06T7/33 ,  G06T2207/30004

摘要： An imaging system (10) includes imaging modalities such as a PET imaging system (12) and a CT scanner (14). The CT scanner (14) is used to produce a first image (62) which is used for primary contouring. The PET system (12) is used to provide a second image (56), which provides complementary information about the same or overlapping anatomical region. After first and second images (62, 56) are registered with one another the first and second images (62, 56) are concurrently segmented to outline a keyhole (76). The keyhole portion of the second image (56) is inserted into the keyhole (76) of the first image (62). The user can observe the composite image and deform a boundary (78) of the keyhole (76) by a mouse (52) to better focus on the region of interest within previously defined keyhole.

摘要翻译： 成像系统（10）包括诸如PET成像系统（12）和CT扫描仪（14）之类的成像模式。 CT扫描器（14）用于产生用于初级轮廓的第一图像（62）。 PET系统（12）用于提供第二图像（56），其提供关于相同或重叠解剖区域的补充信息。 在第一和第二图像（62,56）之间彼此对准之后，第一和第二图像（62,56）被同时分割以勾勒一个键孔（76）。 第二图像（56）的锁孔部分插入第一图像（62）的键孔（76）中。 用户可以观察合成图像并且通过鼠标（52）使键孔（76）的边界（78）变形以更好地聚焦在先前定义的键孔内的感兴趣区域上。

公开(公告)号：US08184129B2

公开(公告)日：2012-05-22

申请号：US13220942

申请日：2011-08-30

申请人： Raj Shekhar ,  Vivek Walimbe

发明人： Raj Shekhar ,  Vivek Walimbe

IPC分类号： G09G5/00

CPC分类号： G01T1/1647 ,  G01T1/1611

摘要： Techniques for registration of multiple measurement modes of a body include receiving first and second data from different modes. Each includes measured values with coordinate values. For two mechanically aligned modes, any non-rigid registration is performed. For some modes, the non-rigid registration includes a coarse transformation and multiple fine scale transformations. The coarse transformation maximizes a coarse similarity measure. The second data is sub-divided into contiguous sub-regions. Fine transformations are determined between the sub-regions and corresponding portions of the first data to maximize a fine similarity measure. Sub-dividing and determining fine transformations repeats until stop conditions are satisfied. Transformations between the last-divided sub-regions are interpolated. Any of the fine similarity measure, a search region, interpolation method, sub-division location, and the use of rigid or non-rigid fine transformations are adaptive to properties of the first or second data so that the registration is automatic without human intervention.

摘要翻译： 用于登记身体的多个测量模式的技术包括从不同模式接收第一和第二数据。 每个都包含具有坐标值的测量值。 对于两个机械对准的模式，执行任何非刚性配准。 对于一些模式，非刚性配准包括粗变换和多精细刻度变换。 粗变换使粗略的相似性度量最大化。 第二数据被细分成连续的子区域。 在子区域和第一数据的对应部分之间确定精细变换以最大化精细相似性度量。 重复分割和确定精细转换，直到满足停止条件。 内插最后划分的子区域之间的变换。 精细相似性度量，搜索区域，插值方法，子分割位置以及使用刚性或非刚性精细变换中的任何一种适应于第一或第二数据的属性，使得在没有人为干预的情况下注册是自动的。

公开(公告)号：US20110280365A1

公开(公告)日：2011-11-17

申请号：US13165367

申请日：2011-06-21

申请人： Shinichi Kojima ,  Takashi Okazaki ,  Yuuichirou Ueno ,  Kikuo Umegaki ,  Kensuke Amemiya ,  Kazuhiro Takeuchi ,  Hiroshi Kitaguchi ,  Kazuma Yokoi ,  Norihito Yanagita

发明人： Shinichi Kojima ,  Takashi Okazaki ,  Yuuichirou Ueno ,  Kikuo Umegaki ,  Kensuke Amemiya ,  Kazuhiro Takeuchi ,  Hiroshi Kitaguchi ,  Kazuma Yokoi ,  Norihito Yanagita

IPC分类号： A61B6/03 ,  G01N23/04

CPC分类号： G01T1/1611 ,  A61B6/037 ,  A61B6/4241 ,  A61B6/5235 ,  G01N23/046 ,  G01N2223/419 ,  G01N2223/612 ,  G01T1/2985 ,  Y10S378/901

摘要： A radiological imaging apparatus of the present invention comprises an image pickup device and a medical examinee holding device that is provided with a bed. The image pickup device includes a large number of radiation detectors and radiation detector support plates. A large number of radiation detectors are mounted around the circumference of a through-hole and arranged in the axial direction of the through-hole. The radiation detectors are arranged in three layers formed radially with respect to the center of the through-hole and mounted on the lateral surfaces of the radiation detector support plates. Since the radiation detectors are not only arranged in the axial direction and circumferential direction of the through-hole but also arrayed in the radial direction, it is possible to obtain accurate information about a γ-ray arrival position in the radial direction of the through-hole (the positional information about a radiation detector from which a γ-ray image pickup signal is output). The use of accurate information about γ-ray arrival increases the tomogram accuracy. As a result, the present invention enhances the, tomogram accuracy, that is, the PET examination accuracy.

摘要翻译： 本发明的放射学成像装置包括：图像拾取装置和设有床的医疗检查者保持装置。 图像拾取装置包括大量的辐射检测器和辐射检测器支撑板。 大量的辐射探测器安装在通孔的圆周周围并沿通孔的轴向布置。 辐射检测器被布置成相对于通孔的中心径向形成的三层，并且安装在辐射检测器支撑板的侧表面上。 由于辐射检测器不仅沿通孔的轴向和圆周方向布置，而且沿径向排列，可以获得关于通孔的径向上的γ射线到达位置的准确信息， （关于从其输出γ射线摄像信号的放射线检测器的位置信息）。 使用关于γ射线到达的准确信息可以增加断层图像的准确性。 结果，本发明提高了断层图像精度，即PET检查精度。

公开(公告)号：US08031211B2

公开(公告)日：2011-10-04

申请号：US13088871

申请日：2011-04-18

申请人： Raj Shekhar ,  Vivek Walimbe

发明人： Raj Shekhar ,  Vivek Walimbe

IPC分类号： G09G5/00

CPC分类号： G01T1/1647 ,  G01T1/1611

摘要： Techniques for registration of multiple measurement modes of a body include receiving first and second data from different modes. Each includes measured values with coordinate values. For two mechanically aligned modes, any non-rigid registration is performed. For some modes, the non-rigid registration includes a coarse transformation and multiple fine scale transformations. The coarse transformation maximizes a coarse similarity measure. The second data is sub-divided into contiguous sub-regions. Fine transformations are determined between the sub-regions and corresponding portions of the first data to maximize a fine similarity measure. Sub-dividing and determining fine transformations repeats until stop conditions are satisfied. Transformations between the last-divided sub-regions are interpolated. Any of the fine similarity measure, a search region, interpolation method, sub-division location, and the use of rigid or non-rigid fine transformations are adaptive to properties of the first or second data so that the registration is automatic without human intervention.

摘要翻译： 用于登记身体的多个测量模式的技术包括从不同模式接收第一和第二数据。 每个都包含具有坐标值的测量值。 对于两个机械对准的模式，执行任何非刚性配准。 对于一些模式，非刚性配准包括粗变换和多精细刻度变换。 粗变换使粗略的相似性度量最大化。 第二数据被细分成连续的子区域。 在子区域和第一数据的对应部分之间确定精细变换以最大化精细相似性度量。 重复分割和确定精细转换，直到满足停止条件。 内插最后划分的子区域之间的变换。 精细相似性度量，搜索区域，插值方法，子分割位置以及使用刚性或非刚性精细变换中的任何一种适应于第一或第二数据的属性，使得在没有人为干预的情况下注册是自动的。