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公开(公告)号：US20220220182A1
公开(公告)日：2022-07-14
申请号：US17709706
申请日：2022-03-31
发明人： Jiaxi WU , Tong ZHANG , Maria del Pilar MOLINA-PORTELA , Eric SMITH , Chia-Yang LIN , Thomas Craig MEAGHER
摘要： The present disclosure relates to IL2 agonists with improved therapeutic profiles.
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公开(公告)号：US20230391844A1
公开(公告)日：2023-12-07
申请号：US18328327
申请日：2023-06-02
发明人： Jiaxi WU , Supriya PATEL , Tong ZHANG , Nicolin BLOCH , Eric SMITH , Chia-Yang LIN , Vidur GARG , Erica ULLMAN
IPC分类号： C07K14/555 , A61P35/00 , C07K14/715
CPC分类号： C07K14/555 , A61P35/00 , C07K14/7155 , A61K38/00
摘要： The present disclosure provides IL2 proproteins comprising an IL2 moiety that is masked with an IL2Rα moiety and a protease-cleavable linker, configured such that the IL2Rα moiety is released from the IL2 moiety upon the action of a protease, e.g., at a tumor site. The IL2 proproteins optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor-associated antigen and directs the proprotein to a tumor site. The disclosure further provides pharmaceutical compositions comprising the IL2 proproteins, and methods of use of the IL2 proproteins in therapy, as well as nucleic acids encoding the IL2 proproteins, recombinant cells that express the IL2 proproteins and methods of producing the IL2 proproteins.
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公开(公告)号：US20230382969A1
公开(公告)日：2023-11-30
申请号：US18324380
申请日：2023-05-26
发明人： Supriya PATEL , Tong ZHANG , Jiaxi WU , Aaron CHANG , Eric SMITH , Chia-Yang LIN , Samuel DAVIS
摘要： The present disclosure provides IL2 proproteins comprising an IL2 moiety that is masked with an IL2Rα moiety and a protease-cleavable linker, configured such that the IL2Rα moiety is released from the IL2 moiety upon the action of a protease, e.g., at a tumor site. The IL2 proproteins optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor-associated antigen and directs the proprotein to a tumor site. The disclosure further provides pharmaceutical compositions comprising the IL2 proproteins, and methods of use of the IL2 proproteins in therapy, as well as nucleic acids encoding the IL2 proproteins, recombinant cells that express the IL2 proproteins and methods of producing the IL2 proproteins.
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公开(公告)号：US20230051304A1
公开(公告)日：2023-02-16
申请号：US17813122
申请日：2022-07-18
发明人： Aaron CHANG , Jiaxi WU , Tong ZHANG , Nicolin BLOCH , Erica ULLMAN , Eric SMITH , Chia-Yang LIN , Samuel DAVIS
摘要： The present disclosure relates to IL12 receptor agonists with improved therapeutic profiles.
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公开(公告)号：US20240287186A1
公开(公告)日：2024-08-29
申请号：US18590725
申请日：2024-02-28
发明人： Aarthi PUTARJUNAN , Kyle STAHMER , Lauren BOUCHER , Lianjie LI , Raquel DEERING , Chia-Yang LIN , George YANCOPOULOS , Johanna HANSEN
CPC分类号： C07K16/2818 , A61P35/00 , C07K14/70539 , C07K16/2803 , C07K16/2809 , C07K16/2887 , C07K16/3076 , C07K2317/31 , C07K2317/52 , C07K2317/56
摘要： The present disclosure relates to multispecific molecules comprising a peptide-MHC complex and an immune cell antigen targeting moiety. Particular aspects relate to multimeric (e.g., dimeric) molecules comprising a peptide-MHC complex, an immune cell antigen targeting moiety, and a multimerization moiety. The disclosure further provides pharmaceutical compositions comprising the multispecific molecules, and methods of use of multispecific molecules in antigen-specific T cell activation, in inducing an antigen-specific immune response, and in therapeutic applications, as well as nucleic acids encoding the multispecific molecules, recombinant cells that express the multispecific molecules, and methods of producing the multispecific molecules.
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公开(公告)号：US20240287162A1
公开(公告)日：2024-08-29
申请号：US18589364
申请日：2024-02-27
发明人： Nianshuang WANG , Yang SHEN , Alina BAUM , Christos KYRATSOUS , Chia-Yang LIN , Tri NGUYEN
CPC分类号： C07K16/1003 , A61P31/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35
摘要： The present disclosure provides multivalent anti-spike protein binding molecules. The present disclosure further relates to the methods of producing the multivalent anti-spike protein binding molecules, pharmaceutical compositions comprising of the multivalent anti-spike protein binding molecules, and methods of use of the multivalent anti-spike protein binding molecules, e.g., to treat conditions associated with SARS-CoV and SARS-CoV-2 infections, such as COVID-19.
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公开(公告)号：US20240252601A1
公开(公告)日：2024-08-01
申请号：US18395175
申请日：2023-12-22
发明人： Nianshuang WANG , Yang SHEN , Alina BAUM , Christos KYRATSOUS , Chia-Yang LIN
CPC分类号： A61K38/48 , A61P31/14 , C12N9/485 , C12Y304/17023 , C07K2319/30
摘要： The present disclosure provides ACE2 fusion proteins, comprising multimerization moieties linked to ACE2 moieties, that specifically bind to RBD regions of SARS-CoV and/or SARS-CoV-2. The present disclosure further relates to the methods of producing the ACE2 fusion proteins, pharmaceutical compositions comprising of the ACE2 fusion proteins, and methods of use of the ACE2 fusion proteins to treat conditions associated with SARS-CoV and SARS-CoV-2 infections, such as COVID-19.
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公开(公告)号：US20240247069A1
公开(公告)日：2024-07-25
申请号：US18412280
申请日：2024-01-12
发明人： Yan YANG , Naga Suhasini AVVARU , Christopher DALY , Yang SHEN , Chia-Yang LIN
CPC分类号： C07K16/2863 , A61P35/00 , A61K2039/505 , C07K2317/31 , C07K2317/55 , C07K2317/622
摘要： The present disclosure relates to molecules capable of binding to FGFR3 and methods of use thereof.
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公开(公告)号：US20240101633A1
公开(公告)日：2024-03-28
申请号：US18452452
申请日：2023-08-18
发明人： Eva-Maria WEICK , Nicolin BLOCH , Vidur GARG , Erica ULLMAN , Tong ZHANG , Chia-Yang LIN , Jiaxi WU , Eric Smith
IPC分类号： C07K14/56 , C07K14/715 , C07K16/28
CPC分类号： C07K14/56 , C07K14/7156 , C07K16/2818 , C07K16/2827 , A61K38/00 , C07K2319/30
摘要： The present disclosure provides interferon receptor agonists with improved safety profiles and therapeutic indices. The interferon receptor agonists are attenuated through masking and/or reduced receptor binding as compared to a wild-type interferon. IFN receptor agonists optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor- or immune cell-associated antigen and directs the interferon receptor agonist to a tumor site and/or tumor-reactive immune cells. The disclosure further provides pharmaceutical compositions comprising the interferon receptor agonists, and methods of use of the interferon receptor agonists in therapy, as well as nucleic acids encoding the interferon receptor agonists, recombinant cells that express the interferon receptor agonists and methods of producing the interferon receptor agonists.
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公开(公告)号：US20230312665A1
公开(公告)日：2023-10-05
申请号：US18298542
申请日：2023-04-11
发明人： Jiaxi WU , Tong ZHANG , Maria del Pilar MOLINA-PORTELA , Eric SMITH , Chia-Yang LIN , Thomas Craig MEAGHER
IPC分类号： C07K14/55 , A61K47/68 , A61P35/00 , C07K14/715 , A61K35/17 , C07K14/74 , A61K38/20 , C07K14/725 , C07K14/705
CPC分类号： C07K14/55 , A61K47/6849 , A61P35/00 , C07K14/7155 , A61K35/17 , C07K14/70539 , A61K38/2013 , C07K14/7051 , C07K14/70517 , A61K38/00
摘要： The present disclosure relates to IL2 agonists with improved therapeutic profiles.
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