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    INTERLEUKIN-2 PROPROTEINS AND USES THEREOF
    2.
    发明公开
    INTERLEUKIN-2 PROPROTEINS AND USES THEREOF 审中-公开

    公开(公告)号：US20230382969A1

    公开(公告)日：2023-11-30

    申请号：US18324380

    申请日：2023-05-26

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： Supriya PATEL ,  Tong ZHANG ,  Jiaxi WU ,  Aaron CHANG ,  Eric SMITH ,  Chia-Yang LIN ,  Samuel DAVIS

    IPC分类号： C07K14/55 ,  A61P35/00

    CPC分类号： C07K14/55 ,  A61P35/00

    摘要： The present disclosure provides IL2 proproteins comprising an IL2 moiety that is masked with an IL2Rα moiety and a protease-cleavable linker, configured such that the IL2Rα moiety is released from the IL2 moiety upon the action of a protease, e.g., at a tumor site. The IL2 proproteins optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor-associated antigen and directs the proprotein to a tumor site. The disclosure further provides pharmaceutical compositions comprising the IL2 proproteins, and methods of use of the IL2 proproteins in therapy, as well as nucleic acids encoding the IL2 proproteins, recombinant cells that express the IL2 proproteins and methods of producing the IL2 proproteins.