公开(公告)号：US11084781B2

公开(公告)日：2021-08-10

申请号：US16612680

申请日：2018-05-10

Applicant: Research Triangle Institute

Inventor： Yanan Zhang ,  Thuy Nguyen ,  Nadezhda German

IPC: C07C275/38 ,  C07D205/04 ,  C07D207/335 ,  C07D211/38 ,  C07D213/643 ,  C07D215/12 ,  C07D239/26 ,  C07D295/135 ,  C07D333/20 ,  C07D487/08 ,  C07D491/107 ,  A61P25/30

Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

公开(公告)号：US20200030287A1

公开(公告)日：2020-01-30

申请号：US16485570

申请日：2018-02-13

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Yanan Zhang ,  Thuy Nguyen

IPC: A61K31/40 ,  A61P25/00

Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.

公开(公告)号：US09187480B2

公开(公告)日：2015-11-17

申请号：US14378479

申请日：2013-02-15

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Rangan Maitra ,  Alan Bradley Fulp ,  Yanan Zhang ,  Herbert H. Seltzman

IPC: C07D401/04 ,  C07D473/32 ,  C07D473/34

CPC classification number: C07D473/34

Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.

Abstract translation: 本发明提供了能够根据下式用作大麻素受体拮抗剂的化合物：这些化合物可用于治疗涉及大麻素受体系统的病症，例如肥胖，肝脏疾病，糖尿病，疼痛和炎症。

公开(公告)号：US09150582B2

公开(公告)日：2015-10-06

申请号：US14363079

申请日：2012-12-06

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Scott Runyon ,  Yanan Zhang ,  Carla Hassler ,  Brian Gilmour

IPC: C07D491/04 ,  A61K31/4355 ,  C07D491/048 ,  C07D491/10 ,  C07D491/107

CPC classification number: C07D491/048 ,  C07D491/04 ,  C07D491/10 ,  C07D491/107

Abstract: Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.

Abstract translation: 提供神经肽S受体拮抗剂，其在功能测定中与神经肽S受体结合; 提供了这些拮抗剂用于治疗通过阻断神经肽S受体而改善的病症或疾病状态的方法，包括药物滥用和药物滥用复发; 并且用于神经肽S受体拮抗剂在制备用于治疗疾病状态和治疗神经肽S受体结合敏感的疾病状态的治疗剂的前药中的用途。