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公开(公告)号：US07531547B2
公开(公告)日：2009-05-12
申请号：US11510216
申请日：2006-08-25
IPC分类号： C07D239/48 , C07D239/50 , A61K31/505 , A61P11/06
CPC分类号： C07D239/48
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物：其中D，X，R 1，R 2 ，R3，R4，R5，R6，R7和R8如本文所定义。
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公开(公告)号：US20080207655A1
公开(公告)日：2008-08-28
申请号：US12072664
申请日：2008-02-27
IPC分类号： A61K31/513 , C07D239/48 , A61P13/02 , A61P25/00 , A61P11/00 , A61P1/00
CPC分类号： C07D239/48
摘要： Compounds of formula (I): wherein R1 and R2 are as defined herein. Also disclosed are methods of making and using the subject compounds.
摘要翻译： 式（I）化合物：其中R 1和R 2如本文所定义。 还公开了制备和使用本发明化合物的方法。
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公开(公告)号：US20080207619A1
公开(公告)日：2008-08-28
申请号：US12072663
申请日：2008-02-27
IPC分类号： A61K31/5377 , C07D239/48 , A61K31/513 , A61P11/00 , A61P13/10 , A61P31/04 , A61P31/12 , A61P25/00 , A61P13/00 , A61P1/00 , C07D413/12
CPC分类号： C07D413/12 , C07D239/46 , C07D239/48 , C07D403/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the compounds being of formula (I): wherein R1, R2, R3 and R4 are as defined herein.
摘要翻译： 用于治疗由P2X 3和/或P2X 2/3受体拮抗剂介导的疾病的化合物和方法，所述式（I）的化合物：其中R R 1，R 2，R 3和R 4如本文所定义。
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公开(公告)号：US20060004075A1
公开(公告)日：2006-01-05
申请号：US11217526
申请日：2005-09-01
IPC分类号： A61K31/4172 , C07D233/44
CPC分类号： C07D401/12 , C07D233/50 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I: wherein A, R1, R2, R3 and R4 are as defined in the specification; and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
摘要翻译： 作为IP受体调节剂，特别是IP受体拮抗剂有效的化合物，其具有式I：其中A，R 1，R 2，R 3， >和R 4>如说明书中所定义; 和各异构体，异构体的外消旋或非外消旋混合物及其药学上可接受的盐或溶剂合物。 还公开了含有这些化合物的药物组合物及其用作治疗剂的方法。
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15.发明申请METHODS OF USING DIAMINOPYRIMIDINE AS P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISEASES 有权使用二氨基嘧啶作为P2X3和P2X2 / 3受体调节剂治疗呼吸道感染和胃肠疾病的方法公开(公告)号：US20120122859A1
公开(公告)日：2012-05-17
申请号：US13186078
申请日：2011-07-19
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P.D.W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P.D.W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
IPC分类号： A61K31/505 , A61P11/00 , A61K31/506 , A61K31/5383
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的呼吸道和胃肠道疾病的方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐， 其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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公开(公告)号：US08008298B2
公开(公告)日：2011-08-30
申请号：US12378977
申请日：2009-02-20
申请人： Joe Timothy Bamberg , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Alam Jahangir , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , David Bernard Smith , Michael Soth , Hanbiao Yang
发明人： Joe Timothy Bamberg , Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Alam Jahangir , Rama K. Kondru , Remy Lemoine , Yan Lou , Timothy D. Owens , David Bernard Smith , Michael Soth , Hanbiao Yang
IPC分类号： A61K31/495
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q1, R, and X are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中变量Q1，R和X如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US07589090B2
公开(公告)日：2009-09-15
申请号：US12072663
申请日：2008-02-27
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D413/12 , C07D239/46 , C07D239/48 , C07D403/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the compounds being of formula (I): wherein R1, R2, R3 and R4 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述化合物具有式（I）：其中R 1，R 2，R 3和R 4如本文所定义。
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公开(公告)号：US20070049758A1
公开(公告)日：2007-03-01
申请号：US11510216
申请日：2006-08-25
申请人： Michael Dillon , Alam Jahangir , Amy Moore , Paul Wagner
发明人： Michael Dillon , Alam Jahangir , Amy Moore , Paul Wagner
IPC分类号： C07D239/46 , C07D403/02
CPC分类号： C07D239/48
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X 3和/或P2X 3/3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的 式（I）的化合物：其中D，X，R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7和R 8如本文所定义。
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公开(公告)号：US20070049534A1
公开(公告)日：2007-03-01
申请号：US11509890
申请日：2006-08-25
申请人： Michael Dillon , Alam Jahangir , Clara Lin
发明人： Michael Dillon , Alam Jahangir , Clara Lin
IPC分类号： A61K31/506 , A61K31/505 , C07K5/04 , A61K38/05 , A61K38/04 , C07D239/48
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the compounds being of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X 3和/或P2X 3/3受体拮抗剂介导的疾病的化合物和方法，所述式（I）的化合物：其中D，X， R 1，R 2，R 3，R 4，R 5， R 6，R 7和R 8如本文所定义。
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20.发明授权Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases 有权使用二氨基嘧啶P2X3和P2X2 / 3受体调节剂治疗呼吸道和胃肠道疾病的方法公开(公告)号：US08008313B2
公开(公告)日：2011-08-30
申请号：US11509921
申请日：2006-08-25
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P. D. W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P. D. W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的呼吸道和胃肠道疾病的方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐， 其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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