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公开(公告)号：US20080207655A1
公开(公告)日：2008-08-28
申请号：US12072664
申请日：2008-02-27
IPC分类号： A61K31/513 , C07D239/48 , A61P13/02 , A61P25/00 , A61P11/00 , A61P1/00
CPC分类号： C07D239/48
摘要： Compounds of formula (I): wherein R1 and R2 are as defined herein. Also disclosed are methods of making and using the subject compounds.
摘要翻译： 式（I）化合物：其中R 1和R 2如本文所定义。 还公开了制备和使用本发明化合物的方法。
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公开(公告)号：US20100144758A1
公开(公告)日：2010-06-10
申请号：US12634031
申请日：2009-12-09
IPC分类号： A61K31/497 , C07D487/02 , A61K31/519 , A61P29/00 , A61P31/12 , A61P33/00 , A61P31/04 , A61P11/06 , A61P11/00
CPC分类号： C07D487/04
摘要： The application discloses compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein, X, R1, R2 R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
摘要翻译： 本申请公开了式I的化合物或其药学上可接受的盐，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。 还提供了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。
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公开(公告)号：US08846705B2
公开(公告)日：2014-09-30
申请号：US12963413
申请日：2010-12-08
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
IPC分类号： A61K31/505 , A61K31/506 , C07D239/48 , C07D403/12
CPC分类号： C07D239/49 , A61K31/505 , A61K31/506 , C07D239/48 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐，溶剂合物或 其前体药物，其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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公开(公告)号：US07799796B2
公开(公告)日：2010-09-21
申请号：US11509890
申请日：2006-08-25
IPC分类号： C07D239/48 , C07D413/12 , A61K31/506
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the compounds being of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述化合物为式（I）：其中D，X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8为 如本文所定义。
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公开(公告)号：US07776872B2
公开(公告)日：2010-08-17
申请号：US11510015
申请日：2006-08-25
IPC分类号： C07D239/48 , C07D401/12 , A61K31/506
CPC分类号： C07D401/12 , C07D239/48 , C07D471/04
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein A, D, E, G, J, X, Y, Z R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
摘要翻译： 式I化合物或其药学上可接受的盐，其中A，D，E，G，J，X，Y，Z R6，R7和R8如本文所定义。 还提供了使用该化合物治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的方法和制备该化合物的方法。
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公开(公告)号：US07531547B2
公开(公告)日：2009-05-12
申请号：US11510216
申请日：2006-08-25
IPC分类号： C07D239/48 , C07D239/50 , A61K31/505 , A61P11/06
CPC分类号： C07D239/48
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物：其中D，X，R 1，R 2 ，R3，R4，R5，R6，R7和R8如本文所定义。
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公开(公告)号：US20080207619A1
公开(公告)日：2008-08-28
申请号：US12072663
申请日：2008-02-27
IPC分类号： A61K31/5377 , C07D239/48 , A61K31/513 , A61P11/00 , A61P13/10 , A61P31/04 , A61P31/12 , A61P25/00 , A61P13/00 , A61P1/00 , C07D413/12
CPC分类号： C07D413/12 , C07D239/46 , C07D239/48 , C07D403/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the compounds being of formula (I): wherein R1, R2, R3 and R4 are as defined herein.
摘要翻译： 用于治疗由P2X 3和/或P2X 2/3受体拮抗剂介导的疾病的化合物和方法，所述式（I）的化合物：其中R R 1，R 2，R 3和R 4如本文所定义。
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8.发明授权Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases 有权使用二氨基嘧啶P2X3和P2X2 / 3受体调节剂治疗呼吸道和胃肠道疾病的方法公开(公告)号：US08008313B2
公开(公告)日：2011-08-30
申请号：US11509921
申请日：2006-08-25
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P. D. W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P. D. W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的呼吸道和胃肠道疾病的方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐， 其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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公开(公告)号：US07858632B2
公开(公告)日：2010-12-28
申请号：US11071555
申请日：2005-03-03
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Ronald Charles Hawley , Alam Jahangir , Clara Jeou Jen Lin , Daniel Warren Parish
IPC分类号： C07D239/48 , C07D403/12 , A61K31/505
CPC分类号： C07D239/49 , A61K31/505 , A61K31/506 , C07D239/48 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐，溶剂合物或 其前体药物，其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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10.发明授权Methods of using diaminopyrimidine as P2X3 and P2X⅔ receptor modulators for treatment of respiratory and gastrointestinal diseases 有权使用二氨基嘧啶作为P2X3和P2X2 / 3受体调节剂治疗呼吸道和胃肠疾病的方法公开(公告)号：US08524725B2
公开(公告)日：2013-09-03
申请号：US13186078
申请日：2011-07-19
申请人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P. D. W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
发明人： Chris Allen Broka , David Scott Carter , Michael Patrick Dillon , Anthony P. D. W. Ford , Ronald Charles Hawley , Alam Jahangir , Amy Geraldine Moore , Daniel Warren Parish
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的呼吸道和胃肠道疾病的方法，所述方法包括向有需要的受试者施用有效量的式（I）化合物或其药学上可接受的盐， 其中D，X，Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。
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