公开(公告)号：US10662187B2

公开(公告)日：2020-05-26

申请号：US16070520

申请日：2017-01-17

Applicant: Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Inventor： Xibin Liao ,  Jia Li ,  Zhijian Lu ,  Yubo Zhou ,  Anhui Gao

IPC: C07D471/04 ,  C07D231/56 ,  A61K45/06 ,  A61K31/437 ,  A61K31/42 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/519 ,  A61P35/00 ,  A61P37/00

Abstract: Bruton's tyrosine kinase (Btk) inhibitors have the following Formula (I):

公开(公告)号：US20190375727A1

公开(公告)日：2019-12-12

申请号：US16348502

申请日：2017-11-08

Applicant: ZHEJIANG UNIVERSITY ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Tao Liu ,  Jia Li ,  Yongzhou Hu ,  Yubo Zhou ,  Xiaowu Dong ,  Anhui Gao ,  Pinrao Song ,  Peipei Wang ,  Lexian Tong ,  Xiaobei Hu ,  Mingbo Su

IPC: C07D401/14 ,  C07D401/12 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D409/14 ,  A61P35/00

Abstract: A 2-substituted aromatic ring-pyrimidine derivative as shown in a general formula I, and an optical isomer or a pharmaceutically acceptable salt or a solvate thereof are provided. The present invention designs and synthesizes a series of novel small molecular Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained through structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess strong anti-cancer effect, Chk1 kinase inhibitory activity and are promising Chk1 inhibitors. The compounds can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal.

公开(公告)号：US09643941B2

公开(公告)日：2017-05-09

申请号：US15301763

申请日：2015-03-27

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Fajun Nan ,  Jia Li ,  Xin Xie ,  Chaojun Gong ,  Yubo Zhou ,  Hui Chai ,  Yangming Zhang ,  Mingbo Su

IPC: C07D277/56 ,  C07D417/04 ,  C07D417/14 ,  C07D277/66 ,  C07D277/60

CPC classification number: C07D277/56 ,  C07D277/60 ,  C07D277/66 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention relates to a thiazole-based compound, a preparation method therefor, and a use thereof. More specifically, the present invention relates to a 2,2′-bis-thiazole-based compound, a preparation method therefor, and a use of 2,2′-bis-thiazole-based compound a histone deacetylase inhibitor in the preparation of an antitumor medicament, a medicament for treating autoimmune diseases, a medicament for treating type II diabetes mellitus and complication thereof, or a medicament for treating neurodegenerative diseases.