公开(公告)号：US10080776B2

公开(公告)日：2018-09-25

申请号：US15162833

申请日：2016-05-24

申请人： Sapporo Medical University ,  Sumitomo Dainippon Pharma Co., Ltd.

发明人： Toshihiko Torigoe ,  Yoshihiko Hirohashi ,  Noriyuki Satoh ,  Kenjiro Kamiguchi ,  Rena Morita ,  Satoshi Nishizawa ,  Akari Takahashi

IPC分类号： A61K38/17 ,  C12N15/113 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/574 ,  C07K7/06 ,  C12N5/0783

CPC分类号： A61K38/177 ,  C07K7/06 ,  C12N5/0638 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5017 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/705

摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.

公开(公告)号：US20180147270A9

公开(公告)日：2018-05-31

申请号：US15534315

申请日：2015-12-08

申请人： Sapporo Medical University ,  Sumitomo Dainippon Pharma Co., Ltd.

发明人： Noriyuki Sato ,  Toshihiko Torigoe ,  Yoshihiko Hirohashi ,  Takayuki Kanaseki ,  Sho Miyamoto ,  Vitaly Kochin ,  Masashi Goto

IPC分类号： A61K39/00 ,  C12Q1/68 ,  C07K7/06 ,  C07K16/28 ,  C07K16/30 ,  C12N5/0783 ,  G01N33/50 ,  G01N33/574

摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by YO-XO-ZO; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.

公开(公告)号：US09399760B2

公开(公告)日：2016-07-26

申请号：US13967410

申请日：2013-08-15

申请人： Sapporo Medical University ,  Dainippon Sumitomo Pharma Co., Ltd.

发明人： Toshihiko Torigoe ,  Yoshihiko Hirohashi ,  Noriyuki Satoh ,  Kenjiro Kamiguchi ,  Rena Morita ,  Satoshi Nishizawa ,  Akari Takahashi

IPC分类号： A61K38/43 ,  C12N5/0783 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/574 ,  C07K7/06

CPC分类号： A61K38/177 ,  C07K7/06 ,  C12N5/0638 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5017 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/705

摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.