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公开(公告)号：US07087408B2
公开(公告)日：2006-08-08
申请号：US10316421
申请日：2002-12-11
CPC分类号： C07K14/62
摘要： Novel insulin precursors and insulin precursor analogs having a mini C-peptide comprising at least one aromatic amino acid residue have an increased folding stability. The novel insulin precursors and insulin precursor analogs can be expressed in yeast in high yields and are preferably not more 15 amino acid residues in length. Also provided are polynucleotide sequences encoding the claimed precursors or precursor analogs, and vectors and cell lines containing such polynucleotide sequences.
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公开(公告)号：US09018161B2
公开(公告)日：2015-04-28
申请号：US12442190
申请日：2007-09-20
申请人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Nørgaard , Svend Havelund
发明人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Nørgaard , Svend Havelund
摘要： The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
摘要翻译： 本发明涉及对蛋白酶表现出抗性的新型胰岛素类似物，其中至少两个氨基酸相对于母体胰岛素分子被取代和/或缺失。 还提供了制备这种胰岛素类似物的方法，含有本发明的胰岛素类似物的胰岛素制剂和使用这些胰岛素类似物治疗糖尿病的方法。
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公开(公告)号：US20110092419A1
公开(公告)日：2011-04-21
申请号：US12922106
申请日：2009-03-19
申请人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
发明人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
摘要： The present invention relates to novel insulin analogues comprising mutations at position A14 in the A chain and at positions B27, B28, B29 and B30 in the B chain and exhibiting resistance towards protease; a method for the preparation of such insulin analogues; insulin preparations containing the insulin analogues of the invention; and, a method of treating diabetes mellitus using these insulin analogues.
摘要翻译： 本发明涉及新的胰岛素类似物，其包含A链A14位和B链位置B27，B28，B29和B30的突变，并表现出对蛋白酶的抗性; 一种制备这种胰岛素类似物的方法; 含有本发明胰岛素类似物的胰岛素制剂; 以及使用这些胰岛素类似物治疗糖尿病的方法。
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公开(公告)号：US20100173844A1
公开(公告)日：2010-07-08
申请号：US12643330
申请日：2009-12-21
申请人： Svend Ludvigsen , Morten Schlein , Tine Elisabeth Gottschalk Boving , Claude Bonde , Anne-Mette Lilleore , Dorthe Kot Engelund , Bjarne Ronfeldt Nielsen
发明人： Svend Ludvigsen , Morten Schlein , Tine Elisabeth Gottschalk Boving , Claude Bonde , Anne-Mette Lilleore , Dorthe Kot Engelund , Bjarne Ronfeldt Nielsen
CPC分类号： A61K47/26 , A61K9/0019 , A61K38/26 , A61K47/10
摘要： Stable pharmaceutical composition comprising insulinotropic peptide.
摘要翻译： 包含促胰岛素肽的稳定的药物组合物。
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公开(公告)号：US20100009898A1
公开(公告)日：2010-01-14
申请号：US12442190
申请日：2007-09-20
申请人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Norgaard , Svend Havelund
发明人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Norgaard , Svend Havelund
摘要： The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
摘要翻译： 本发明涉及对蛋白酶表现出抗性的新型胰岛素类似物，其中至少两个氨基酸相对于母体胰岛素分子被取代和/或缺失。 还提供了制备这种胰岛素类似物的方法，含有本发明的胰岛素类似物的胰岛素制剂和使用这些胰岛素类似物治疗糖尿病的方法。
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公开(公告)号：US08748376B2
公开(公告)日：2014-06-10
申请号：US12643330
申请日：2009-12-21
申请人： Svend Ludvigsen , Morten Schlein , Tine Elisabeth Gottschalk Bøving , Claude Bonde , Anne-Mette Lilleøre , Dorthe Kot Engelund , Bjarne Rønfeldt Nielsen
发明人： Svend Ludvigsen , Morten Schlein , Tine Elisabeth Gottschalk Bøving , Claude Bonde , Anne-Mette Lilleøre , Dorthe Kot Engelund , Bjarne Rønfeldt Nielsen
IPC分类号： A61K38/26 , C07K14/605
CPC分类号： A61K47/26 , A61K9/0019 , A61K38/26 , A61K47/10
摘要： Stable pharmaceutical composition comprising insulinotropic peptide.
摘要翻译： 包含促胰岛素肽的稳定的药物组合物。
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18.发明授权Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast 有权制备酵母中发酵产量提高的胰岛素前体和胰岛素前体类似物的方法公开(公告)号：US08129146B2
公开(公告)日：2012-03-06
申请号：US12104809
申请日：2008-04-17
IPC分类号： C12N15/17
CPC分类号： C07K14/62
摘要： Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 Å.
摘要翻译： 提供了包含优选至多15个氨基酸残基并且包含至少一个Gly的连接肽（小C肽）的新型胰岛素前体和胰岛素前体类似物。 前体可转化为人胰岛素或人胰岛素类似物。 前体通常具有小于5埃的B27（原子CG2）和A1（原子CA）之间的距离。
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公开(公告)号：US06521738B2
公开(公告)日：2003-02-18
申请号：US09736611
申请日：2000-12-14
IPC分类号： C07K1462
CPC分类号： C07K14/62
摘要： Novel insulin precursors and insulin precursor analogs having a mini C-peptide comprising at least one aromatic amino acid residue have an increased folding stability. The novel insulin precursors and insulin precursor analogs can be expressed in yeast in high yields and are preferably not more 15 amino acid residues in length. Also provided are polynucleotide sequences encoding the claimed precursors or precursor analogs, and vectors and cell lines containing such polynucleotide sequences.
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公开(公告)号：US09260502B2
公开(公告)日：2016-02-16
申请号：US12922106
申请日：2009-03-13
申请人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
发明人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
摘要： The present invention relates to novel insulin analogs comprising mutations at position A14 in the A chain and at positions B27, B28, B29 and B30 in the B chain and exhibiting resistance towards protease; a method for the preparation of such insulin analogs; insulin preparations containing the insulin analogs of the invention; and, a method of treating diabetes mellitus using these insulin analogs.
摘要翻译： 本发明涉及新的胰岛素类似物，其包含A链A14位和B链位置B27，B28，B29和B30处的突变，并表现出对蛋白酶的抗性; 一种制备这种胰岛素类似物的方法; 含有本发明胰岛素类似物的胰岛素制剂; 以及使用这些胰岛素类似物治疗糖尿病的方法。
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