公开(公告)号：US07125970B1

公开(公告)日：2006-10-24

申请号：US09857372

申请日：1999-12-06

申请人： Roland Henri Contreras ,  Bart Jozef Maria Nelissen ,  Marianne Denise De Backer ,  Walter Herman Maria Louis Luyten ,  Jasmine Elza Viaene ,  Marc George Logghe ,  Jorge Eduardo Vialard

发明人： Roland Henri Contreras ,  Bart Jozef Maria Nelissen ,  Marianne Denise De Backer ,  Walter Herman Maria Louis Luyten ,  Jasmine Elza Viaene ,  Marc George Logghe ,  Jorge Eduardo Vialard

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

CPC分类号： C07K14/40 ,  A61K38/00

摘要： The present invention is concerned with the identification of genes or functional fragments thereof from Candida albicans which are critical for growth and cell division and which genes may be used as selective drug targets to treat Candida albicans associated infections. Novel nucleic acid sequences from Candida albicans are also provided and which encode the polypeptides which are critical for growth of Candida albicans. Methods for the identification of anti-fungal compounds which inhibit fungal or yeast growth are also contemplated.

摘要翻译： 本发明涉及鉴定对于生长和细胞分裂至关重要的白色念珠菌的基因或其功能片段，哪些基因可用作治疗白色念珠菌相关感染的选择性药物靶标。 还提供了来自白色念珠菌的新型核酸序列，其编码对白色念珠菌生长至关重要的多肽。 还考虑了用于鉴定抑制真菌或酵母生长的抗真菌化合物的方法。