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11.发明授权Production of sucralose without intermediate isolation of crystalline sucralose-6-ester 失效生产三氯半乳蔗糖而不中间分离结晶三氯半乳蔗糖-6-酯
公开(公告)号：US5498709A
公开(公告)日：1996-03-12
申请号：US448710
申请日：1995-05-24
CPC分类号： C07H5/02
摘要： There is disclosed a process for producing sucralose from sucralose-6-ester whereby the sucralose-6-ester is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination reaction mixture, to produce an aqueous solution of sucralose plus salts and impurities, from which sucralose is recovered by extraction and is then preferably purified by crystallization.
摘要翻译： 公开了一种由三氯蔗糖-6-酯制备三氯半乳蔗糖的方法，由此三氯蔗糖-6-酯在从中和的氯化反应混合物中除去叔胺反应载体之前或之后直接脱酰基，以产生三氯半乳蔗糖的水溶液 加上盐和杂质，通过萃取从其中回收三氯蔗糖，然后优选通过结晶纯化。
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公开(公告)号：US5298611A
公开(公告)日：1994-03-29
申请号：US30518
申请日：1993-03-12
摘要： A process for producing substantially pure sucralose pentaester from a mixture of 6-O-acyl-4,1' ,6' -trichloro-4,1',6'-trideoxygalactosucrose in a reaction medium comprising a tertiary amide, wherein said process comprises the steps of:(a) recovering the 6-O-acyl-4,1' ,6' -trichloro-4,1' ,6' -trideoxygalactosucrose from said mixture;(b) peracylating the 6-O-acyl-4,1' ,6' -trichloro-4,1' ,6' -trideoxygalactosucrose product of step (a) to produce thereby 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester; and(c) crystallizing the 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester product of step (b) to produce substantially pure 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester.
摘要翻译： 一种从含有叔酰胺的反应介质中由6-O-酰基-4,1'，6'-三氯-4,1'，6'-三脱氧半乳蔗糖的混合物制备基本上纯的三氯蔗糖五酯的方法，其中所述方法包括 步骤：（a）从所述混合物中回收6-O-酰基-4,1'，6'-三氯-4,1'，6'-三脱氧半乳糖蔗糖; （b）使步骤（a）的6-O-酰基-4,1'，6'-三氯-4,1'，6'-三脱氧半乳糖蔗糖酯过酰化从而产生4,1'，6'-三氯-4 ，1'，6'-三脱氧半乳蔗糖五酯; 和（c）使步骤（b）的4,1'，6'-三氯-4,1'，6'-三脱氧半乳糖蔗糖五酯产物结晶以产生基本上纯的4,1'，6'-三氯-4,1' 6'-三脱氧半乳蔗糖五酯。
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13.发明授权Selective 6-acylation of sucrose mediated by cyclic adducts of dialkyltin oxides and diols 失效二环烷基氧化物和二醇的循环添加引起的蔗糖的选择性6-取代
公开(公告)号：US5089608A
公开(公告)日：1992-02-18
申请号：US499731
申请日：1990-03-23
CPC分类号： C07H13/04 , C07F7/2232 , C07H13/06 , C07H13/08 , C07H23/00
摘要： There is disclosed a process which comprises the steps of:(a) reacting a di(hydrocarbyl)tin oxide such as a dialkyltin oxide with a dihydric alcohol, alkanolamine, or an enolizable .alpha.-hydroxyketone in an inert organic reaction vehicle, with removal of water, at a temperature and for a period of time sufficient to produce a cyclic adduct of said dialkyltin oxide and said dihydric alcohol, alkanolamine, or enolizable .alpha.-hydroxyketone;(b) reacting said cyclic adduct product of Step (a) with sucrose in an inert organic reaction vehicle such as a dipolar aprotic liquid, at a temperature and for a period of time sufficient to produce a 6-O-[dihydrocarbyl(hydroxy- or amino- or oxohydrocarbyl)stannoxyl]sucrose; and(c) reacting the product of Step (b) with an acylating agent to produce a sucrose-6-ester.
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