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11.发明授权Compounds which inhibit human conjunctival mast cell degranulation for treating ocular allergic-type complications 失效抑制人结膜肥大细胞脱颗粒治疗眼部过敏型并发症的化合物公开(公告)号：US06225327B1
公开(公告)日：2001-05-01
申请号：US09171045
申请日：1998-10-07
IPC分类号： A01N4340
CPC分类号： A61K9/0048 , A61K31/4422 , A61K31/443 , A61K31/4439 , Y10S514/912
摘要： Composition and methods for treating ocular allergic reactions are disclosed. In particular, the invention is directed to compounds which inhibit human conjunctival mast cell degranulation.
摘要翻译： 公开了用于治疗眼部过敏反应的组合物和方法。 特别地，本发明涉及抑制人结膜肥大细胞脱粒的化合物。
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12.发明申请RNAi-Mediated Inhibition of Spleen Tyrosine Kinase-Related Inflammatory Conditions 有权RNAi介导的脾脏酪氨酸激酶相关炎症病症的抑制公开(公告)号：US20110288157A1
公开(公告)日：2011-11-24
申请号：US13172964
申请日：2011-06-30
IPC分类号： A61K31/7105 , A61P27/02 , A61K31/713 , A61P29/00
CPC分类号： C12N15/1137 , A61K31/7105 , A61K31/713 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2310/531 , C12N2320/30
摘要： RNA interference is provided for inhibition of spleen tyrosine kinase (Syk) mRNA expression, in particular, for treating patients having a Syk-related inflammatory condition or at risk of developing a Syk-related inflammatory condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, allergy, or mast-cell disease.
摘要翻译： 提供RNA干扰用于抑制脾脏酪氨酸激酶（Syk）mRNA表达，特别是用于治疗患有Syk相关炎性病症的患者或具有发展Syk相关炎性病症如过敏性结膜炎，眼部炎症，皮炎， 鼻炎，哮喘，过敏或肥大细胞疾病。
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13.发明授权公开(公告)号：US08541389B2
公开(公告)日：2013-09-24
申请号：US13035147
申请日：2011-02-25
申请人： John M. Yanni , Jon E. Chatterton , Diane Michelle Senchyna , Daniel A. Gamache , Steven T. Miller
发明人： John M. Yanni , Jon E. Chatterton , Diane Michelle Senchyna , Daniel A. Gamache , Steven T. Miller
IPC分类号： C12N15/11
CPC分类号： C12N15/1138 , A61K31/7088 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2310/346 , C12N2310/351 , C12N2320/30
摘要： RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.
摘要翻译： 通过沉默TNFα细胞表面受体TNF受体-1（TNFR1）mRNA表达或沉默TNFα转化酶（TACE / ADAM17）mRNA表达，提供RNA干扰抑制肿瘤坏死因子α（TNFalpha）。 特别是沉默这种TNFα靶标，可用于治疗患有TNFalpha相关病症或有发生TNFalpha相关病症风险的患者，如眼病干眼症，过敏性结膜炎或眼部炎症，或诸如皮炎，鼻炎 ，或哮喘。
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14.发明授权公开(公告)号：US08222227B2
公开(公告)日：2012-07-17
申请号：US13173512
申请日：2011-06-30
IPC分类号： C12N15/11
CPC分类号： C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/141
摘要： RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or at risk of developing an HRH1-related condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, or allergy.
摘要翻译： 提供RNA干扰用于抑制组胺受体H1mRNA表达，特别是用于治疗患有HRH1相关病症或具有发生HRH1相关病症的风险的患者，例如过敏性结膜炎，眼部炎症，皮炎，鼻炎，哮喘或 过敏。
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15.发明申请公开(公告)号：US20120264809A1
公开(公告)日：2012-10-18
申请号：US13493098
申请日：2012-06-11
IPC分类号： A61K31/713 , A61P11/06 , A61P17/00 , A61P37/08 , A61P29/00
CPC分类号： C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/141
摘要： RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or at risk of developing an HRH1-related condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, or allergy.
摘要翻译： 提供RNA干扰用于抑制组胺受体H1mRNA表达，特别是用于治疗患有HRH1相关病症或具有发生HRH1相关病症的风险的患者，例如过敏性结膜炎，眼部炎症，皮炎，鼻炎，哮喘或 过敏。
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16.发明授权公开(公告)号：US07732421B2
公开(公告)日：2010-06-08
申请号：US11750262
申请日：2007-05-17
申请人： John M. Yanni , Jon E. Chatterton , Diane Michelle Senchyna , Daniel A. Gamache , Steven T. Miller
发明人： John M. Yanni , Jon E. Chatterton , Diane Michelle Senchyna , Daniel A. Gamache , Steven T. Miller
CPC分类号： C12N15/1138 , A61K31/7088 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2310/346 , C12N2310/351 , C12N2320/30
摘要： RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.
摘要翻译： 通过沉默TNFα细胞表面受体TNF受体-1（TNFR1）mRNA表达或沉默TNFα转化酶（TACE / ADAM17）mRNA表达，提供RNA干扰抑制肿瘤坏死因子α（TNFα）。 特别是沉默这样的TNFα靶标可用于治疗患有TNFα相关病症或具有发展TNFα相关病症如眼病干眼症，过敏性结膜炎或眼部炎症或诸如皮炎，鼻炎的患者的患者 ，或哮喘。
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17.发明申请RNAi-Mediated Inhibition of Spleen Tyrosine Kinase-Related Inflammatory Conditions 有权RNAi介导的脾脏酪氨酸激酶相关炎症病症的抑制公开(公告)号：US20090324507A1
公开(公告)日：2009-12-31
申请号：US12296621
申请日：2007-04-13
IPC分类号： A61K9/12 , A61K31/7105 , A61K48/00
CPC分类号： C12N15/1137 , A61K31/7105 , A61K31/713 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2310/531 , C12N2320/30
摘要： RNA interference is provided for inhibition of spleen tyrosine kinase (Syk) mRNA expression, in particular, for treating patients having a Syk-related inflammatory condition or at risk of developing a Syk-related inflammatory condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, allergy, or mast-cell disease.
摘要翻译： 提供RNA干扰用于抑制脾脏酪氨酸激酶（Syk）mRNA表达，特别是用于治疗患有Syk相关炎性病症的患者或具有发展Syk相关炎性病症如过敏性结膜炎，眼部炎症，皮炎， 鼻炎，哮喘，过敏或肥大细胞疾病。
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18.发明申请Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis 审中-公开使用抑制TNFa Plus抗组胺药治疗过敏性鼻炎和过敏性结膜炎公开(公告)号：US20080254029A1
公开(公告)日：2008-10-16
申请号：US12100715
申请日：2008-04-10
IPC分类号： A61K39/395 , A61K31/551 , A61K31/335 , A61K31/55 , A61P37/08 , A61K38/16 , A61K31/4353 , A61K31/52
CPC分类号： A61K45/06 , A61K31/335 , A61K31/551 , A61K38/191 , A61K39/395 , A61K2300/00
摘要： Disclosed are methods of treating allergic conjunctivitis and allergic rhinitis in a subject that involve topically administering to the subject a composition comprising a pharmaceutically effective amount of an H1 antagonist and an anti-TNFα compound.
摘要翻译： 公开了治疗过敏性结膜炎和过敏性鼻炎的方法，其涉及向受试者局部施用包含药学有效量的H 1拮抗剂和抗TNFα化合物的组合物。
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公开(公告)号：US06274160B1
公开(公告)日：2001-08-14
申请号：US09529837
申请日：2000-04-19
IPC分类号： A61K906
CPC分类号： A61K31/425 , A61K31/17 , A61K31/4178 , Y10S514/887 , Y10S514/944
摘要： A topical ophthalmic composition for the treatment of dry eye in humans, comprising one or more histamine H2 agonists, is disclosed.
摘要翻译： 公开了一种用于治疗人类干眼症的局部用眼用组合物，其包含一种或多种组胺H2激动剂。
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20.发明授权Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders 失效含有二十二碳四烯酸衍生物的组合物和用于治疗干眼症的方法
公开(公告)号：US5696166A
公开(公告)日：1997-12-09
申请号：US551021
申请日：1995-10-31
IPC分类号： A61K31/00 , A61K31/16 , A61K31/20 , A61K31/202 , A61K31/23 , A61K31/232 , A61P27/00 , A61P27/04 , A61K31/19 , A61K31/215
CPC分类号： A61K31/202 , Y10S514/912
摘要： Compositions containing a HETE derivative and methods of use for treating dry eye are disclosed.
摘要翻译： 公开了含有HETE衍生物的组合物和用于治疗干眼症的方法。
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