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1.发明授权Compounds which inhibit human conjunctival mast cell degranulation for treating ocular allergic-type complications 失效抑制人结膜肥大细胞脱颗粒治疗眼部过敏型并发症的化合物公开(公告)号：US06225327B1
公开(公告)日：2001-05-01
申请号：US09171045
申请日：1998-10-07
IPC分类号： A01N4340
CPC分类号： A61K9/0048 , A61K31/4422 , A61K31/443 , A61K31/4439 , Y10S514/912
摘要： Composition and methods for treating ocular allergic reactions are disclosed. In particular, the invention is directed to compounds which inhibit human conjunctival mast cell degranulation.
摘要翻译： 公开了用于治疗眼部过敏反应的组合物和方法。 特别地，本发明涉及抑制人结膜肥大细胞脱粒的化合物。
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2.发明申请RNAi-Mediated Inhibition of Spleen Tyrosine Kinase-Related Inflammatory Conditions 有权RNAi介导的脾脏酪氨酸激酶相关炎症病症的抑制公开(公告)号：US20110288157A1
公开(公告)日：2011-11-24
申请号：US13172964
申请日：2011-06-30
IPC分类号： A61K31/7105 , A61P27/02 , A61K31/713 , A61P29/00
CPC分类号： C12N15/1137 , A61K31/7105 , A61K31/713 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2310/531 , C12N2320/30
摘要： RNA interference is provided for inhibition of spleen tyrosine kinase (Syk) mRNA expression, in particular, for treating patients having a Syk-related inflammatory condition or at risk of developing a Syk-related inflammatory condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, allergy, or mast-cell disease.
摘要翻译： 提供RNA干扰用于抑制脾脏酪氨酸激酶（Syk）mRNA表达，特别是用于治疗患有Syk相关炎性病症的患者或具有发展Syk相关炎性病症如过敏性结膜炎，眼部炎症，皮炎， 鼻炎，哮喘，过敏或肥大细胞疾病。
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公开(公告)号：US06492552B2
公开(公告)日：2002-12-10
申请号：US09841859
申请日：2001-04-25
申请人： Zixia Feng , Mark R. Hellberg , Steven T. Miller
发明人： Zixia Feng , Mark R. Hellberg , Steven T. Miller
IPC分类号： C07C27300
CPC分类号： C07C323/44 , Y10S514/826 , Y10S514/861 , Y10S514/912
摘要： Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.
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公开(公告)号：US06492418B2
公开(公告)日：2002-12-10
申请号：US09843131
申请日：2001-04-25
申请人： Steven T. Miller , Mark R. Hellberg , Zixia Feng
发明人： Steven T. Miller , Mark R. Hellberg , Zixia Feng
IPC分类号： A61K31225
CPC分类号： A61K31/5375 , A61K9/0048 , A61K31/10 , A61K31/166 , A61K31/167 , Y10S514/912
摘要： Methods and compositions for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The compositions contain a mast cell stabilizing disulfide derivative as an active ingredient.
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公开(公告)号：US06452052B1
公开(公告)日：2002-09-17
申请号：US10062377
申请日：2002-01-31
申请人： Mark R. Hellberg , Zixia Feng , Steven T. Miller
发明人： Mark R. Hellberg , Zixia Feng , Steven T. Miller
IPC分类号： C07C23300
CPC分类号： C07C323/43 , A61K31/165 , A61K31/325 , C07C323/41
摘要： Methods and compositions for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The compositions contain a mast cell stabilizing disulfide derivative as an active ingredient.
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6.发明授权公开(公告)号：US08541389B2
公开(公告)日：2013-09-24
申请号：US13035147
申请日：2011-02-25
申请人： John M. Yanni , Jon E. Chatterton , Diane Michelle Senchyna , Daniel A. Gamache , Steven T. Miller
发明人： John M. Yanni , Jon E. Chatterton , Diane Michelle Senchyna , Daniel A. Gamache , Steven T. Miller
IPC分类号： C12N15/11
CPC分类号： C12N15/1138 , A61K31/7088 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2310/346 , C12N2310/351 , C12N2320/30
摘要： RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.
摘要翻译： 通过沉默TNFα细胞表面受体TNF受体-1（TNFR1）mRNA表达或沉默TNFα转化酶（TACE / ADAM17）mRNA表达，提供RNA干扰抑制肿瘤坏死因子α（TNFalpha）。 特别是沉默这种TNFα靶标，可用于治疗患有TNFalpha相关病症或有发生TNFalpha相关病症风险的患者，如眼病干眼症，过敏性结膜炎或眼部炎症，或诸如皮炎，鼻炎 ，或哮喘。
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7.发明授权公开(公告)号：US08222227B2
公开(公告)日：2012-07-17
申请号：US13173512
申请日：2011-06-30
IPC分类号： C12N15/11
CPC分类号： C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/141
摘要： RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or at risk of developing an HRH1-related condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, or allergy.
摘要翻译： 提供RNA干扰用于抑制组胺受体H1mRNA表达，特别是用于治疗患有HRH1相关病症或具有发生HRH1相关病症的风险的患者，例如过敏性结膜炎，眼部炎症，皮炎，鼻炎，哮喘或 过敏。
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![3,6-substituted imidazol[1,2-b]pyridazine analogs for treating allergic and inflammatory diseases](/abs-image/US/2011/03/15/US07906512B2/abs.jpg.150x150.jpg)
8.发明授权3,6-substituted imidazol[1,2-b]pyridazine analogs for treating allergic and inflammatory diseases 有权3,6-取代咪唑并[1,2-b]哒嗪类似物用于治疗过敏性和炎性疾病公开(公告)号：US07906512B2
公开(公告)日：2011-03-15
申请号：US12720808
申请日：2010-03-10
IPC分类号： A01N43/58 , A01N43/60 , A01N43/52 , A61K31/50 , A61K31/495 , A61K31/501 , A61K31/415 , C07D487/00 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D235/02 , C07D403/02
CPC分类号： A61K31/5025 , C07D473/04 , C07D487/04 , Y02A50/411
摘要： Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 3,6-substituted imidazol[1,2-b]pyridazine compound.
摘要翻译： 用于治疗过敏性或炎性疾病或其它Syk介导的疾病或Syk介导的病症的方法，其特征在于施用含有治疗有效量的3,6-取代的咪唑并[1,2-b]哒嗪化合物的组合物。
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9.发明授权5-substituted 2-aminopyridine analogs for treating allergic and inflammatory diseases 有权用于治疗过敏性和炎性疾病的5-取代的2-氨基吡啶类似物公开(公告)号：US07799778B1
公开(公告)日：2010-09-21
申请号：US11330629
申请日：2006-01-12
IPC分类号： A61K31/535 , A61K31/50 , A61K31/497 , A61K31/44 , A01N43/58 , A01N43/42 , C07D221/18 , C07D221/22 , C07D401/00 , C07D421/00 , C07D405/00
CPC分类号： C07D213/74 , A61K31/44 , A61K31/497 , A61K31/50 , A61K31/535 , C07D405/04 , Y02A50/411
摘要： Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 5-substituted 2-aminopyridine compound.
摘要翻译： 用于治疗过敏性或炎性疾病或其它Syk介导的疾病或Syk介导的病症的方法，其特征在于施用含有治疗有效量的5-取代的2-氨基吡啶化合物的组合物。
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![3,6-SUBSTITUTED IMIDAZOL[1,2-B]PYRIDAZINE ANALOGS FOR TREATING ALLERGIC AND INFLAMMATORY DISEASES](/abs-image/US/2010/07/01/US20100168116A1/abs.jpg.150x150.jpg)
10.发明申请3,6-SUBSTITUTED IMIDAZOL[1,2-B]PYRIDAZINE ANALOGS FOR TREATING ALLERGIC AND INFLAMMATORY DISEASES 有权3,6-取代的咪唑烷[1,2-B]吡嗪类模拟物用于治疗过敏和炎症疾病公开(公告)号：US20100168116A1
公开(公告)日：2010-07-01
申请号：US12720808
申请日：2010-03-10
IPC分类号： A61K31/5025 , A61P37/08 , A61P29/00
CPC分类号： A61K31/5025 , C07D473/04 , C07D487/04 , Y02A50/411
摘要： Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 3,6-substituted imidazol[1,2-b]pyridazine compound.
摘要翻译： 用于治疗过敏性或炎性疾病或其它Syk介导的疾病或Syk介导的病症的方法，其特征在于施用含有治疗有效量的3,6-取代的咪唑并[1,2-b]哒嗪化合物的组合物。
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