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    Polymeric devices for controlled release of active agents
    16.
    发明申请
    Polymeric devices for controlled release of active agents 失效
    用于控释活性剂的聚合物

    公开(公告)号：US20090004272A1

    公开(公告)日：2009-01-01

    申请号：US11888639

    申请日：2007-07-31

    申请人： John W. Gibson ,  Arthur J. Tipton

    发明人： John W. Gibson ,  Arthur J. Tipton

    IPC分类号： A61K9/00 ,  A61K38/00

    CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/2031 ,  A61K38/09 ,  A61K38/24

    摘要： Polymeric devices for controlled release of an active agent of interest are provided. The active agent is provided within a biodegradable polymer system to supply a polymeric device for controlled release of the active agent. The polymer system is a copolymer or a polymer blend comprising a hydrophobic component and a hydrophilic component, and the polymer system does not form a hydrogel when contacted with, or immersed in an aqueous system, for example when the device is implanted in a subject. When the device is administered to a subject, for example, when it is implanted, the device releases the active agent in a controlled fashion without a lag period, or with a minimal lag period. Methods for producing the polymeric devices are also provided, as are methods of using the polymeric devices to provide for controlled release of an active agent in a subject.

    摘要翻译： 提供了用于感兴趣的活性剂的控制释放的聚合装置。 活性剂提供在可生物降解的聚合物体系内，以提供用于活性剂的受控释放的聚合物装置。 聚合物体系是包含疏水组分和亲水组分的共聚物或聚合物共混物，并且聚合物体系当与例如当将该装置植入受试者中时与水系统接触或浸没在水系统中时不形成水凝胶。 当将装置施用于受试者时，例如，当其被植入时，该装置以受控的方式释放活性剂，而没有滞后期或具有最小滞后期。 还提供了生产聚合物装置的方法，以及使用聚合物装置来提供受试者中活性剂的受控释放的方法。

    Zero-order prolonged release coaxial implants
    17.
    发明申请
    Zero-order prolonged release coaxial implants 审中-公开
    零级延长释放同轴植入物

    公开(公告)号：US20080166391A1

    公开(公告)日：2008-07-10

    申请号：US11888667

    申请日：2007-07-31

    申请人： John W. Gibson ,  Arthur J. Tipton ,  Richard I. Holl ,  Stacey Meador

    发明人： John W. Gibson ,  Arthur J. Tipton ,  Richard I. Holl ,  Stacey Meador

    IPC分类号： A61F2/02 ,  A61K38/02 ,  A61K38/16 ,  A61P43/00

    CPC分类号： A61K9/0002 ,  A61F2/02 ,  A61F2250/0067 ,  A61K9/0024

    摘要： A coaxial implant has been developed using entirely biodegradable polymeric materials. As referred to herein, a coaxial implant is a device having a core containing drug, surrounded by a semi-permeable membrane that controls the rate of release of material from the core. The device is formed by extrusion, using a pre-milling and extruding step to maximize uniformity of drug dispersion within the polymeric material. In one embodiment, the polymer is processed to yield a semi-crystalline polymer, rather than an amorphous polymer. The core containing the drug and the polymer membrane(s) can be the same or different polymer. The polymer can be the same or different composition (i.e., both polycaprolactone, or both poly(lactide-co-glycolide) of different monomer ratios, or polycaprolactone outside of a core of poly(lactide)), of the same or different molecular weights, and of the same or different chemical structure (i.e., crystalline, semi-crystalline or amorphous). The core acts as a reservoir of drug, which partitions from the core polymer to form a saturated solution of at least 10% drug at the polymer membrane.

    摘要翻译： 已经开发了使用完全可生物降解的聚合材料的同轴植入物。 如本文所提及的，同轴植入物是具有含核心的药物的装置，被半透膜隔断，半透膜控制材料从核心释放的速率。 该装置通过挤出形成，使用预研磨和挤出步骤以最大化聚合物材料内药物分散的均匀性。 在一个实施方案中，加工聚合物以产生半结晶聚合物，而不是无定形聚合物。 含有药物和聚合物膜的核心可以是相同或不同的聚合物。 聚合物可以具有相同或不同的组成（即，不同单体比的聚己内酯或聚（丙交酯 - 共 - 乙交酯）或聚（丙交酯）核心外的聚己内酯）具有相同或不同分子量 ，以及相同或不同的化学结构（即结晶，半结晶或无定形）。 核心作为药物储存器，其与芯聚合物分隔开，以在聚合物膜上形成至少10％药物的饱和溶液。

    Polymeric device for controlled release of active agents
    18.
    发明授权
    Polymeric device for controlled release of active agents 失效
    用于活性剂控制释放的聚合装置

    公开(公告)号：US08722078B2

    公开(公告)日：2014-05-13

    申请号：US11888668

    申请日：2007-07-31

    申请人： John W. Gibson ,  Arthur J. Tipton

    发明人： John W. Gibson ,  Arthur J. Tipton

    IPC分类号： A61F2/00 ,  C07K14/00

    CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/2031 ,  A61K38/09 ,  A61K38/24

    摘要： Polymeric devices for controlled release of an active agent of interest are provided. The active agent is provided within a biodegradable polymer system to supply a polymeric device for controlled release of the active agent. The polymer system is a copolymer or a polymer blend comprising a hydrophobic component and a hydrophilic component, and the polymer system does not form a hydrogel when contacted with, or immersed in an aqueous system, for example when the device is implanted in a subject. When the device is administered to a subject, for example, when it is implanted, the device releases the active agent in a controlled fashion without a lag period, or with a minimal lag period. Methods for producing the polymeric devices are also provided, as are methods of using the polymeric devices to provide for controlled release of an active agent in a subject.

    摘要翻译： 提供了用于感兴趣的活性剂的控制释放的聚合装置。 活性剂提供在可生物降解的聚合物体系内，以提供用于活性剂的受控释放的聚合物装置。 聚合物体系是包含疏水组分和亲水组分的共聚物或聚合物共混物，并且聚合物体系当与例如当将该装置植入受试者中时与水系统接触或浸没在水系统中时不形成水凝胶。 当将装置施用于受试者时，例如，当其被植入时，该装置以受控的方式释放活性剂，而没有滞后期或具有最小滞后期。 还提供了生产聚合物装置的方法，以及使用聚合物装置来提供受试者中活性剂的受控释放的方法。

    Polymeric devices for controlled release of active agents
    19.
    发明授权
    Polymeric devices for controlled release of active agents 失效
    用于控释活性剂的聚合物

    公开(公告)号：US08647657B2

    公开(公告)日：2014-02-11

    申请号：US11888639

    申请日：2007-07-31

    申请人： John W. Gibson ,  Arthur J. Tipton

    发明人： John W. Gibson ,  Arthur J. Tipton

    IPC分类号： A61K38/00 ,  C07K14/00

    CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/2031 ,  A61K38/09 ,  A61K38/24

    摘要： Polymeric devices for controlled release of an active agent of interest are provided. The active agent is provided within a biodegradable polymer system to supply a polymeric device for controlled release of the active agent. The polymer system is a copolymer or a polymer blend comprising a hydrophobic component and a hydrophilic component, and the polymer system does not form a hydrogel when contacted with, or immersed in an aqueous system, for example when the device is implanted in a subject. When the device is administered to a subject, for example, when it is implanted, the device releases the active agent in a controlled fashion without a lag period, or with a minimal lag period. Methods for producing the polymeric devices are also provided, as are methods of using the polymeric devices to provide for controlled release of an active agent in a subject.

    摘要翻译： 提供了用于感兴趣的活性剂的控制释放的聚合装置。 活性剂提供在可生物降解的聚合物体系内，以提供用于活性剂的受控释放的聚合物装置。 聚合物体系是包含疏水组分和亲水组分的共聚物或聚合物共混物，并且聚合物体系当与例如当将该装置植入受试者中时与水系统接触或浸没在水系统中时不形成水凝胶。 当将装置施用于受试者时，例如，当其被植入时，该装置以受控的方式释放活性剂，而没有滞后期或具有最小滞后期。 还提供了生产聚合物装置的方法，以及使用聚合物装置来提供受试者中活性剂的受控释放的方法。