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公开(公告)号：US11918831B2
公开(公告)日：2024-03-05
申请号：US17464665
申请日：2021-09-01
申请人： Susan L. Michaud , Ran Tu , Daniel J. Raymond
发明人： Susan L. Michaud , Ran Tu , Daniel J. Raymond
CPC分类号： A61N5/1077 , A61B6/03 , A61N5/1044 , A61N5/1067 , A61N5/1082 , G21K1/087 , G21K1/093 , G21K5/04 , A61N5/107 , A61N2005/1074 , A61N2005/1087 , A61N2005/1097 , H01J35/147
摘要： The invention comprises a method and apparatus for treating a tumor of a patient with positively charged particles, comprising the steps of transporting the positively charged particles along a beam transport path passing sequentially from an accelerator, through a beam transport line, through a nozzle, and toward a position of the patient, the step of transporting further comprising the steps of: (1) terminating a first Bragg peak, of a first set of the positively charged particles, in a position of the tumor and (2) flash treating the tumor with a second Bragg peak, of a second set of the positively charged particles, the second Bragg peak terminating post-patient relative to the nozzle. Optionally the second set of particles are delivered at a rate exceeding one MHz. Optionally, particles in common are used to both treat the tumor and image the tumor.
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公开(公告)号：US20240066325A1
公开(公告)日：2024-02-29
申请号：US18387604
申请日：2023-11-07
申请人： Susan L. Michaud , Daniel J. Raymond , Artur Teymurazyan , Ran Tu
发明人： Susan L. Michaud , Daniel J. Raymond , Artur Teymurazyan , Ran Tu
CPC分类号： A61N5/1077 , A61B6/03 , A61N5/1044 , A61N5/1067 , A61N5/1082 , G21K1/087 , G21K1/093 , G21K5/04 , A61N5/107 , A61N2005/1074 , A61N2005/1087 , A61N2005/1097 , H01J35/147
摘要： The invention comprises a method and apparatus for tuning a charged particle beam path of a charged particle beam system used to treat a tumor of a patient, comprising the steps of: positioning a two-dimensional charged particle detector in a beam line downstream from a magnet pair; operating windings of the magnet pair at a first power level to generate a first magnetic field; measuring a beam position with the first two-dimensional charged particle detector; adjusting a correction magnetic field by driving voltage of a correction coil at a second power level, the second power level less than five percent of the first power level, where the first magnetic field and the correction magnetic field combine to yield an operational magnetic field; and the steps of measuring and adjusting the correction magnetic field changing the operational magnetic field to adjust a measured beam position toward a target beam position.
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公开(公告)号：US20210393987A1
公开(公告)日：2021-12-23
申请号：US17464665
申请日：2021-09-01
申请人： Susan L. Michaud , Ran Tu , Daniel J. Raymond
发明人： Susan L. Michaud , Ran Tu , Daniel J. Raymond
摘要： The invention comprises a method and apparatus for treating a tumor of a patient with positively charged particles, comprising the steps of transporting the positively charged particles along a beam transport path passing sequentially from an accelerator, through a beam transport line, through a nozzle, and toward a position of the patient, the step of transporting further comprising the steps of: (1) terminating a first Bragg peak, of a first set of the positively charged particles, in a position of the tumor and (2) flash treating the tumor with a second Bragg peak, of a second set of the positively charged particles, the second Bragg peak terminating post-patient relative to the nozzle. Optionally the second set of particles are delivered at a rate exceeding one MHz. Optionally, particles in common are used to both treat the tumor and image the tumor.
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公开(公告)号：US20210353966A1
公开(公告)日：2021-11-18
申请号：US17382044
申请日：2021-07-21
申请人： Susan L. Michaud , Daniel J. Raymond , Artur Teymurazyan , Ran Tu
发明人： Susan L. Michaud , Daniel J. Raymond , Artur Teymurazyan , Ran Tu
摘要： The invention comprises a method and apparatus for tuning a charged particle beam path of a charged particle beam system used to treat a tumor of a patient, comprising the steps of: positioning a two-dimensional charged particle detector in a beam line downstream from a magnet pair; operating windings of the magnet pair at a first power level to generate a first magnetic field; measuring a beam position with the first two-dimensional charged particle detector; adjusting a correction magnetic field by driving voltage of a correction coil at a second power level, the second power level less than five percent of the first power level, where the first magnetic field and the correction magnetic field combine to yield an operational magnetic field; and the steps of measuring and adjusting the correction magnetic field changing the operational magnetic field to adjust a measured beam position toward a target beam position.
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公开(公告)号：US10143854B2
公开(公告)日：2018-12-04
申请号：US15260763
申请日：2016-09-09
摘要： The invention comprises a method and apparatus for imaging a tumor of a patient using one or more imaging systems positionable about the tumor and treating the tumor using positively charged particles, such as: (1) using a rotatable gantry support to support and rotate a section of a positively charged particle beam transport line about a rotation axis and a tumor of a patient; (2) using a rotatable and optionally extendable secondary support to support, circumferentially position, and laterally position a primary and optional secondary imaging system about the tumor; (3) image the tumor using the primary and optional secondary imaging system as a function of rotation and/or translation of the secondary support; and (4) treat, optionally concurrently with imaging, the tumor using the positively charged particles as a function of circumferential position of the section of the charged particle beam about the tumor.
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16.发明授权公开(公告)号：US09737272B2
公开(公告)日：2017-08-22
申请号：US15207309
申请日：2016-07-11
CPC分类号： A61B6/4216 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1044 , A61N5/1067 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises an apparatus and method of use thereof for determining a charged particle beam state after passage through a final beam modification insert and prior to entering a patient, such as in cancer treatment or tomographic imaging. The insert comprises a range shifter, a known energy absorber, a ridge filter, a focal length altering insert, an aperture defining element, a compensator, and/or a patient specific beam modifier. The monitoring element comprises one or more sheets, configured to emit photons upon passage therethrough of the charged particle beam, where the emitted photons are detected, tested, such as against a predetermined cancer treatment plan, and/or used to aid in three dimensional tomographic image generation.
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公开(公告)号：US11925818B2
公开(公告)日：2024-03-12
申请号：US17399415
申请日：2021-08-11
CPC分类号： A61N5/1077 , A61B6/03 , A61N5/1044 , A61N5/1067 , A61N5/1082 , G21K1/087 , G21K1/093 , G21K5/04 , A61N5/107 , A61N2005/1074 , A61N2005/1087 , A61N2005/1097 , H01J35/147
摘要： The invention comprises a method and apparatus for treating a tumor of a patient with positively charged particles, comprising the steps of: (1) transporting the positively charged particles sequentially from an accelerator, through a beam transport line, through a nozzle, and toward a position of the tumor; (2) treating the tumor with first particles, of the positively charged particles, where at least fifty percent of the first particles pass through a patient position, from the nozzle, to a post-patient position; and (3) detecting a beam position of the first particles in the post-patient position with a detector. The flash treatment preferably delivers the first particles at a rate exceeding one MHz.
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公开(公告)号：US20210370101A1
公开(公告)日：2021-12-02
申请号：US17399415
申请日：2021-08-11
摘要： The invention comprises a method and apparatus for treating a tumor of a patient with positively charged particles, comprising the steps of: (1) transporting the positively charged particles sequentially from an accelerator, through a beam transport line, through a nozzle, and toward a position of the tumor; (2) treating the tumor with first particles, of the positively charged particles, where at least fifty percent of the first particles pass through a patient position, from the nozzle, to a post-patient position; and (3) detecting a beam position of the first particles in the post-patient position with a detector. The flash treatment preferably delivers the first particles at a rate exceeding one MHz.
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19.发明申请DUAL ROTATION CHARGED PARTICLE IMAGING / TREATMENT APPARATUS AND METHOD OF USE THEREOF 审中-公开双轮充电颗粒成像/处理装置及其使用方法公开(公告)号：US20160375269A1
公开(公告)日：2016-12-29
申请号：US15260763
申请日：2016-09-09
CPC分类号： A61N5/1039 , A61B6/032 , A61B6/0457 , A61B6/4092 , A61B6/4258 , A61B6/4266 , A61B6/50 , A61B6/5205 , A61N5/1037 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1081 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08
摘要： The invention comprises a method and apparatus for imaging a tumor of a patient using one or more imaging systems positionable about the tumor and treating the tumor using positively charged particles, such as: (1) using a rotatable gantry support to support and rotate a section of a positively charged particle beam transport line about a rotation axis and a tumor of a patient; (2) using a rotatable and optionally extendable secondary support to support, circumferentially position, and laterally position a primary and optional secondary imaging system about the tumor; (3) image the tumor using the primary and optional secondary imaging system as a function of rotation and/or translation of the secondary support; and (4) treat, optionally concurrently with imaging, the tumor using the positively charged particles as a function of circumferential position of the section of the charged particle beam about the tumor.
摘要翻译： 本发明包括一种使用可以围绕肿瘤定位的一个或多个成像系统对患者的肿瘤进行成像的方法和装置，所述成像系统可以使用带正电的粒子来处理，例如：（1）使用可旋转的支架来支撑和旋转部分 关于旋转轴线和患者肿瘤的带正电的粒子束输送线; （2）使用可旋转和任选可延伸的辅助支撑件来支撑，周向地定位和横向定位关于肿瘤的主要和任选的次要成像系统; （3）使用主要和可选的二次成像系统对肿瘤进行成像，作为辅助支架的旋转和/或平移的函数; 和（4）可选地同时使用正电荷的颗粒成像肿瘤，作为围绕肿瘤的带电粒子束的截面的圆周位置的函数。
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20.发明申请HYBRID CHARGED PARTICLE / X-RAY - IMAGING / TREATMENT APPARATUS AND METHOD OF USE THEREOF 审中-公开混合填充颗粒/ X射线成像/处理设备及其使用方法公开(公告)号：US20160367207A1
公开(公告)日：2016-12-22
申请号：US15257686
申请日：2016-09-06
CPC分类号： A61B6/5205 , A61B6/032 , A61B6/0457 , A61B6/4092 , A61B6/4258 , A61B6/4266 , A61B6/50 , A61N5/1037 , A61N5/1039 , A61N5/1044 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K1/10 , G21K5/04
摘要： The invention comprises a method and apparatus for imaging and treating a tumor of a patient using positively charged particles and X-rays. A mounting rail, supporting a scintillation detection system element and an X-ray detection system element, is alternatingly extended/retracted to position the required detection system element opposite a patient tumor position from an exit nozzle of a beam transport system connected to an accelerator of the positively charged particles, where the positively charged particles are alternatingly used to treat the tumor via irradiation. The mounting rail optionally rotates with rotation of the exit nozzle about the patient, such as with rotation of a support gantry.
摘要翻译： 本发明包括用于使用带正电的粒子和X射线成像和治疗患者的肿瘤的方法和装置。 支撑闪烁检测系统元件和X射线检测系统元件的安装轨道交替地延伸/缩回以将与病人肿瘤位置相对的所需检测系统元件与连接到 带正电的颗粒，其中带正电的颗粒被交替地用于通过照射来治疗肿瘤。 安装导轨可随着出口喷嘴绕患者的旋转而旋转，例如随着支撑台架的旋转。
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