专利检索 ap:("Susan Yoshiko Tamura" OR "Joseph Edward Semple" OR "William Charles Ripka" OR "Robert John Ardecky" OR "Yu Ge" OR "Stephen H. Carpenter" OR "Terence K. Brunck" OR "Marguerita S. L. Lim-Wilby" OR "Ruth F. Nutt" OR "Matthew M. Abelman") AND inv:"Robert John Ardecky" 第 2 页

11.

发明授权
Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors 失效

公开(公告)号：US5770600A

公开(公告)日：1998-06-23

申请号：US473647

申请日：1995-06-06

申请人： Matthew Mark Abelman , Robert John Ardecky , Ruth Foelsche Nutt

发明人： Matthew Mark Abelman , Robert John Ardecky , Ruth Foelsche Nutt

IPC分类号： A61K38/00 , A61P7/02 , C07K5/06 , C07K5/062 , C07K5/072 , C07K5/078 , A61K31/535 , A61K31/445 , C07D401/12 , C07D413/12

CPC分类号： C07K5/0606 , A61K38/00

摘要： This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.