公开(公告)号：US20070231088A1

公开(公告)日：2007-10-04

申请号：US11397172

申请日：2006-04-04

申请人： James Waggle ,  Dennis McNamara ,  Ronald Dudzinsky ,  Larry Meenan ,  Lewis Morrison

发明人： James Waggle ,  Dennis McNamara ,  Ronald Dudzinsky ,  Larry Meenan ,  Lewis Morrison

IPC分类号： B23C5/00 ,  B23B27/22

CPC分类号： B23C5/006 ,  B23B27/22 ,  B23C2230/04 ,  B23C2260/80 ,  Y10T82/10 ,  Y10T407/118 ,  Y10T407/1906 ,  Y10T407/1908 ,  Y10T407/2202 ,  Y10T407/2268 ,  Y10T407/24 ,  Y10T408/909

摘要： A toolholder for use in a metalworking operation, with a body extending along a longitudinal axis and a recess extending within the first end of the body. Adjacent an insert pocket adapted to receive a cutting insert in the recess is at least one wall with a portion having a surface with multiple interruptions to form a chip ejection segment. The chip ejection segment may be an integral part of the toolholder body or may be a discrete piece removably attached to the toolholder body. A method of imparting to a toolholder such a chip ejection segment is also disclosed.

摘要翻译： 一种用于金属加工操作的刀架，具有沿着纵向轴线延伸的主体和在主体的第一端部内延伸的凹部。 相邻于适于在凹部中接收切割插入物的插入口是至少一个壁，其中具有多个中断的表面的部分形成芯片排出段。 芯片排出段可以是刀架主体的整体部分，或者可以是可移除地附接到刀架主体的分立件。 还公开了一种赋予刀架这样的排屑段的方法。

公开(公告)号：US20070049600A1

公开(公告)日：2007-03-01

申请号：US11553935

申请日：2006-10-27

申请人： William Denny ,  Gordon Rewcastle ,  Ellen Dobrusin ,  James Kramer ,  Dennis McNamara ,  Howard Daniel Showalter ,  Peter Toogood

发明人： William Denny ,  Gordon Rewcastle ,  Ellen Dobrusin ,  James Kramer ,  Dennis McNamara ,  Howard Daniel Showalter ,  Peter Toogood

IPC分类号： C07D475/02 ,  A61K31/525

CPC分类号： C07D475/00

摘要： Disclosed are compounds of the formula wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, (un)substituted heteroaryl, or (un)substituted carbocycle or heterocycle; Q is hydrogen or lower alkyl; R4 and R6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl; and R8 is hydrogen, lower alkyl or an (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen; or R8 is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl. These compounds are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. The present invention also provides a method of treating cell proliferative disorders. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.

摘要翻译： 公开了下式的化合物其中：W是NH，S，SO或SO 2; R 2是（未）取代的芳基，（未）取代的杂芳基或（取代的）取代的碳环或杂环; Q是氢或低级烷基; R 4和R 6相同或不同，表示氢，卤素，低级烷基，低级烷氧基，（未）取代的芳基，（未）取代的杂芳基，（un ）取代的芳基烷基或（未）取代的杂芳基烷基; 和R 8是氢，低级烷基或含有3-7个成员的（未）取代的碳环，其中至多两个成员任选是选自氧和氮的杂原子; 或（R 8）是（un）取代的芳基，（未）取代的杂芳基，（未）取代的芳基烷基或（未）取代的杂芳基烷基。 这些化合物可用于治疗细胞增殖性疾病，如癌症和再狭窄。 这些化合物是细胞周期蛋白依赖性激酶（cdks）和生长因子介导的激酶的有效抑制剂。 本发明还提供了治疗细胞增殖性疾病的方法。 本发明还提供了含有式I化合物的药学上可接受的组合物。