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    Process of making calcium hypochlorite
    2.
    发明授权
    Process of making calcium hypochlorite 失效
    制造次氯酸钙的工艺

    公开(公告)号：US3956471A

    公开(公告)日：1976-05-11

    申请号：US484932

    申请日：1974-07-01

    申请人： Brian James Pullman ,  William Denny Mant ,  Gordon Leigh Ross

    发明人： Brian James Pullman ,  William Denny Mant ,  Gordon Leigh Ross

    IPC分类号： C01B11/06

    CPC分类号： C01B11/064

    摘要： In the known process of preparing a slurry of calcium hypochlorite by reaction of chlorine with a slurry of calcium hydroxide and sodium hydroxide, we provide the improvement consisting of continuously pumping into a first stirred reactor an aqueous slurry of calcium hydroxide and sodium hydroxide optionally partially chlorinated and simultaneously passing chlorine gas into the reaction mixture at such a rate that the redox potential is in the range from 650-850 mV and allowing the contents of the first reactor to overflow continuously into a second stirred reactor and simultaneously passing chlorine gas into the second reactor at such a rate that the redox potential is in the range from 750-950 mV and allowing the contents of the second reactor to overflow and be removed as product; the temperature of the contents of the first and second reactor are independently maintained at a temperature in the range 15.degree. to 35.degree.C.

    摘要翻译： 在通过氯与氢氧化钙和氢氧化钠的浆料反应来制备次氯酸钙的浆料的已知方法中，我们提供了改进，其包括将第一搅拌反应器中的氢氧化钙和氢氧化钠的含水浆料任选地部分氯化 同时使氯气进入反应混合物，使得氧化还原电位在650-850mV的范围内，并使第一反应器的内容物连续溢出到第二搅拌反应器中，同时使氯气进入第二反应器 反应器以使得氧化还原电位在750-950mV范围内并允许第二反应器的内容物溢出并作为产物除去的速率; 第一和第二反应器的内容物的温度独立地保持在15℃至35℃的温度。

    Quinoline derivatives for modulating DNA methylation
    7.
    发明授权
    Quinoline derivatives for modulating DNA methylation 失效
    用于调节DNA甲基化的喹啉衍生物

    公开(公告)号：US07790746B2

    公开(公告)日：2010-09-07

    申请号：US11959181

    申请日：2007-12-18

    申请人： Pasit Phiasivongsa ,  Sanjeev G. Redkar ,  Swarna Gamage ,  Darby Brooke ,  William Denny ,  David J. Bearss ,  Hariprasad Vankayalapati

    发明人： Pasit Phiasivongsa ,  Sanjeev G. Redkar ,  Swarna Gamage ,  Darby Brooke ,  William Denny ,  David J. Bearss ,  Hariprasad Vankayalapati

    IPC分类号： A61K31/47

    CPC分类号： C07D401/12

    摘要： Quinoline derivatives, particularly 4-anilinoquinoline derivatives of formula (I), are provided: Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT 1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.

    摘要翻译： 提供了喹啉衍生物，特别是式（I）的4-苯胺基喹啉衍生物：这样的喹啉衍生物可用于DNA甲基化的调节，例如有效抑制胞嘧啶在C-5位甲基化，例如通过选择性抑制 DNA甲基转移酶DNMT 1.提供了合成大量4-苯胺基喹啉衍生物和调节DNA甲基化的方法。 还提供了用于配制和施用这些化合物或组合物以治疗诸如癌症和血液学疾病的病症的方法。