公开(公告)号：US06217867B1

公开(公告)日：2001-04-17

申请号：US09177704

申请日：1998-10-22

Applicant: Suzanne T. Ildstad

Inventor： Suzanne T. Ildstad

IPC: A61K39395

CPC classification number: A61K41/00 ,  A61K47/68 ,  A61K47/6803

Abstract: The present invention relates to non-lethal methods of conditioning a recipient for bone marrow transplantation. In particular, it relates to the use of nonlethal doses of total body irradiation, total lymphoid irradiation, cell type-specific or cell marker-specific antibodies, especially antibodies directed to bone marrow stromal cell markers, NK cells, or the CD8 cell marker, cytotoxic drugs, or a combination thereof. The methods of the invention have a wide range of applications, including, but not limited to, the conditioning of an individual for hematopoietic reconstitution by bone marrow transplantation for the treatment of hematologic malignancies, hematologic disorders, autoimmunity, infectious diseases such as acquired immunodeficiency syndrome, and the engraftment of bone marrow cells to induce tolerance for solid organ, tissue and cellular transplantation.

Abstract translation: 本发明涉及调节骨髓移植受体的非致死方法。 特别涉及使用非致死剂量的全身照射，总淋巴样照射，细胞类型特异性或细胞标志物特异性抗体，特别是针对骨髓基质细胞标志物，NK细胞或CD8细胞标记的抗体， 细胞毒性药物或其组合。 本发明的方法具有广泛的应用，包括但不限于通过骨髓移植造血重建用于治疗血液恶性肿瘤，血液病，自身免疫，感染性疾病如获得性免疫缺陷综合征 ，以及骨髓细胞的移植以诱导对实体器官，组织和细胞移植的耐受性。

公开(公告)号：US5514364A

公开(公告)日：1996-05-07

申请号：US120256

申请日：1993-09-13

Applicant: Suzanne T. Ildstad

Inventor： Suzanne T. Ildstad

IPC: A61K41/00 ,  A61K47/48 ,  A61K51/00 ,  A61K31/00 ,  A61N5/00

CPC classification number: A61K47/48384 ,  A61K41/00 ,  A61K47/48369

Abstract: The present invention relates to non-lethal methods of conditioning a recipient for bone marrow transplantation. In particular, it relates to the use of sublethal doses of total body irradiation, cell type-specific antibodies, especially antibodies directed to bone marrow stromal cell markers, cytotoxic drugs, or a combination thereof. The methods of the invention have a wide range of applications, including, but not limited to, the conditioning of an individual for hematopoietic reconstitution by bone marrow transplantation for the treatment of hematologic malignancies, hematologic disorders, autoimmunity, infectious diseases such as acquired immunodeficiency syndrome, and the engraftment of bone marrow cells to induce tolerance for solid organ, tissue and cellular transplantation.

Abstract translation: 本发明涉及调节骨髓移植受体的非致死方法。 特别涉及使用亚致死剂量的全身照射，细胞型特异性抗体，特别是针对骨髓基质细胞标志物，细胞毒性药物或其组合的抗体。 本发明的方法具有广泛的应用，包括但不限于通过骨髓移植造血重建用于治疗血液恶性肿瘤，血液病，自身免疫，感染性疾病如获得性免疫缺陷综合征 ，以及骨髓细胞的移植以诱导对实体器官，组织和细胞移植的耐受性。