公开(公告)号：US12097290B2

公开(公告)日：2024-09-24

申请号：US13827906

申请日：2013-03-14

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming (Jack) Hu ,  Ronnie Hongbo Fang ,  Jonathan Copp

IPC: A61K9/14 ,  A61K39/00 ,  A61K39/085 ,  A61K39/39 ,  A61K45/06

CPC classification number: A61K9/148 ,  A61K39/001102 ,  A61K39/085 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55555 ,  A61K2039/80

Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.

公开(公告)号：US20170079909A1

公开(公告)日：2017-03-23

申请号：US15126342

申请日：2015-03-20

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Weiwei Gao ,  Jonathan Copp

IPC: A61K9/06 ,  A61L27/54 ,  A61K9/00 ,  A61L27/52

CPC classification number: A61K9/06 ,  A61K9/0019 ,  A61K9/1629 ,  A61K9/5068 ,  A61K9/5115 ,  A61K9/5153 ,  A61K9/5176 ,  A61K31/49 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K35/58 ,  A61K35/63 ,  A61K38/1709 ,  A61K45/06 ,  A61L26/008 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/404 ,  A61L2400/12 ,  Y02A50/473 ,  A61K2300/00

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.