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公开(公告)号：US20240342343A1
公开(公告)日：2024-10-17
申请号：US18682652
申请日：2022-05-18
IPC分类号： A61L27/56 , A61L27/16 , A61L27/38 , A61L27/52 , A61L27/54 , B32B3/02 , B32B3/26 , B32B3/30 , B32B7/05 , B32B27/08 , B32B27/30 , B32B27/36
CPC分类号： A61L27/56 , A61L27/16 , A61L27/3804 , A61L27/52 , A61L27/54 , B32B3/02 , B32B3/26 , B32B3/30 , B32B7/05 , B32B27/08 , B32B27/304 , B32B27/36 , B29K2995/0056 , B32B2250/24 , B32B2255/10 , B32B2535/00
摘要： An open type implantable cell delivery device for transplanting cells in a subject, comprising: a bottom film having a surface area with a plurality of pores; a top film having a surface area with a plurality of pores, positioned on top of the bottom film such that the top film substantially covers the bottom film to create an inner space; wherein the bottom film and the top film are formed from a biocompatible biomaterial, and wherein the bottom film comprises a plurality of microwells positioned to face the surface area of the top film with the open sides of said microwells, wherein the pore size of the bottom film and optionally the top film is such that it allows vascularization or vascular ingrowth in the device through the pores.
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公开(公告)号：US20240342072A1
公开(公告)日：2024-10-17
申请号：US18582331
申请日：2024-02-20
申请人： Allergan, Inc.
CPC分类号： A61K8/735 , A61K8/042 , A61L27/20 , A61L27/52 , A61Q19/00 , A61Q19/08 , C08B37/0072 , A61K2800/91 , A61L2400/06 , A61L2430/34
摘要： The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.
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公开(公告)号：US12115332B2
公开(公告)日：2024-10-15
申请号：US17516179
申请日：2021-11-01
发明人： Klearchos Papas
CPC分类号： A61M37/0069 , A61F2/022 , A61L27/52 , A61L27/54 , A61L2300/62 , A61M2202/03 , A61M2205/04
摘要： Embodiments of the present disclosure relate to encapsulation devices, systems and methods of use. In some embodiments, encapsulation devices for housing cells and providing various therapeutic benefits to a patient or host are described. Encapsulation devices include, for example, a matrix or scaffold within a cell-receiving area or void. Encapsulation devices may include channels that are operable to convey fluid to internal areas of devices without restricting vascularization.
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公开(公告)号：US12109330B2
公开(公告)日：2024-10-08
申请号：US17570549
申请日：2022-01-07
发明人： Amelie Barbara Hildegarde Beduer , Thomas Braschler , Philippe Renaud , Giorgio Pietramaggiori , Saja Scherer
CPC分类号： A61L27/56 , A61L27/227 , A61L27/3616 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/505
摘要： The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.
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公开(公告)号：US12109329B2
公开(公告)日：2024-10-08
申请号：US17055798
申请日：2019-05-23
发明人： Kyung Suk Yum , Amirali Nojoomi
摘要： The approach described herein uses the spatially and temporally controlled growth for programming 3D shapes and their motions, possibly with an unlimited number of degrees of freedom, could thus create dynamic 3D structures. The ability to program growth-induced 3D shapes and motions could transform the way engineering systems, such as robots, actuators, and artificial muscles, are designed. The concept is applicable to other programmable materials. The 2D printing approach for 3D material programming represents a scalable and customizable 3D manufacturing technology, which can potentially be integrated with biological systems and existing 2D fabrication methods and devices for broader applications.
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公开(公告)号：US20240317900A1
公开(公告)日：2024-09-26
申请号：US18573732
申请日：2022-06-22
发明人： Radovan VUKICEVIC , Colin DRABE , Patrick PLITT , Jens NEUBAUER
IPC分类号： C08B37/08 , A61L27/22 , A61L27/52 , C07K14/435
CPC分类号： C08B37/0072 , A61L27/227 , A61L27/52 , C07K14/43586 , A61L2400/06 , A61L2430/34
摘要： The invention proposes a method for preparing a cross-linked material, comprising forming amide bonds that conjugate one or more fibroin moieties with one or more polysaccharide moieties. The invention further relates to a cross-linked material obtainable from such method and to an injectable composition comprising the obtained cross-linked material. The cross-linked material can be a hydrogel and/or a super-volumizer and can be used in cosmetic and pharmaceutical applications.
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7.发明公开公开(公告)号：US20240316249A1
公开(公告)日：2024-09-26
申请号：US18674215
申请日：2024-05-24
发明人： Moon Suk KIM , Seung Hun Park , Hyeon Jin Ju
CPC分类号： A61L27/52 , A61L27/20 , A61L27/54 , A61L27/56 , A61L2400/06
摘要： The present invention relates to an injection formulation composition for use as a filler or a drug carrier through a click chemistry reaction. More specifically, the present invention relates to an injection formulation composition comprising: a first liquid comprising a first biopolymer having a first click chemistry functional group introduced thereinto; and a second liquid comprising a second biopolymer having a second click chemistry functional group introduced thereinto, wherein the first click chemistry functional group is chemically linkable with the second click chemistry functional group, to a method for preparing an injection formulation hydrogel using the composition, and to a medical filler, an in-vivo injection type supporter, or a drug carrier using the composition.
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公开(公告)号：US20240315250A1
公开(公告)日：2024-09-26
申请号：US18734194
申请日：2024-06-05
申请人： Nevada Naturals Inc.
IPC分类号： A01N47/44 , A01N37/36 , A01N43/16 , A61L15/20 , A61L15/46 , A61L15/60 , A61L17/00 , A61L26/00 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A01N47/44 , A01N37/36 , A01N43/16 , A61L15/20 , A61L15/46 , A61L15/60 , A61L17/005 , A61L27/34 , A61L27/52 , A61L27/54 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A01N2300/00 , A61L26/0066 , A61L2300/406 , A61L2400/04
摘要： Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation NαC8-C16 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.
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公开(公告)号：US20240299627A1
公开(公告)日：2024-09-12
申请号：US18281974
申请日：2022-03-22
发明人： Robert Luxenhofer , Lukas Hahn
IPC分类号： A61L27/52 , A61L27/18 , B29C64/40 , B29K96/04 , B29K105/00 , B29K105/16 , B33Y70/00 , B33Y80/00 , C08G73/02 , C08J3/075
CPC分类号： A61L27/52 , A61L27/18 , B29C64/40 , B33Y70/00 , B33Y80/00 , C08G73/0233 , C08J3/075 , B29K2096/04 , B29K2105/0061 , B29K2105/0085 , B29K2105/16 , C08J2379/04
摘要： Provided is a block copolymer comprising a polymer block (A) which comprises repeating units of formula (I) and a polymer block (B) which comprises repeating units of formula (II),
wherein R1 is methyl or ethyl, and R2 represents a group —CH2—CH2-phenyl. The copolymer of the present invention allows a rapid thermoresponsive inverse gelation to be achieved, yielding a hydrogel with viscoelastic solid-like properties, as well as shear thinning, rapid structure recovery and good strain resistance properties. The hydrogel can be favorably used in 3D printing applications.-
公开(公告)号：US20240299615A1
公开(公告)日：2024-09-12
申请号：US18702663
申请日：2022-04-11
发明人： Seung Woo CHO , Yi Sun CHOI , Ji Hoon JEON
IPC分类号： A61L24/00 , A61K9/06 , A61K45/06 , A61K47/18 , A61K47/38 , A61L24/08 , A61L27/20 , A61L27/38 , A61L27/52 , C08B15/06 , C08B15/10 , C08J3/075 , C08J3/24 , C08L1/08
CPC分类号： A61L24/0031 , A61K9/06 , A61K45/06 , A61K47/18 , A61K47/38 , A61L24/08 , A61L27/20 , A61L27/3834 , A61L27/52 , C08B15/06 , C08B15/10 , C08J3/075 , C08J3/24 , C08L1/08 , A61L2400/04 , C08J2301/08 , C08L2203/02 , C08L2312/00
摘要： A hydrogel including phenol derivative-modified cellulose, a use thereof, and a preparation method therefor are described. Physical properties of the hydrogel can be modulated by adjusting concentrations of and oxidation conditions for the phenol derivative-modified cellulose. In addition, the hydrogel of the present invention can find applications in various fields due to its properties, such as hemostasis, blood coagulation acceleration, tissue adhesion, cell culture, cell transplantation, drug delivery, etc.
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