公开(公告)号：US20150112283A1

公开(公告)日：2015-04-23

申请号：US14579490

申请日：2014-12-22

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Hanae TAGAMI ,  Hiroyuki KATO

IPC: A61M37/00 ,  B29C39/02

CPC classification number: A61M37/0015 ,  A61K9/0014 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C39/026 ,  B29K2001/08 ,  B29L2031/759

Abstract: A method for manufacturing a needle-shaped body, including supplying a first aqueous solution to an intaglio plate, supplying a second aqueous solution to the intaglio plate, drying the first and second aqueous solutions in the intaglio plate such that a dried body is formed on the intaglio plate, and separating the dried body from the intaglio plate such that a needle-shaped body including a needle-shaped projection and a support base which supports the needle-shaped projection is obtained. The intaglio plate includes a recess corresponding to the needle-shaped projection, the first aqueous solution is supplied to fill at least a portion of the recess, the first aqueous solution and the second aqueous solution are immiscible, the first aqueous solution forms a projection side layer in the needle-shaped body, and the second aqueous solution forms a support base side layer on the projection side layer in the needle-shaped body.

Abstract translation: 一种针状体的制造方法，包括将第一水溶液供给到凹版，将第二水溶液供给到所述凹版上，干燥所述凹版中的所述第一和第二水溶液，使得在所述凹版上形成干燥体 凹版，并将干燥体与凹版印刷体分离，得到包括针状突起的针状体和支撑针状突起的支撑基体。 凹版板包括对应于针状突起的凹部，供给第一水溶液以填充凹部的至少一部分，第一水溶液和第二水溶液不混溶，第一水溶液形成突出侧 并且第二水溶液在针状体的突出侧层上形成支撑基底侧层。

公开(公告)号：US20170319393A1

公开(公告)日：2017-11-09

申请号：US15659733

申请日：2017-07-26

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Hiroyuki KATO

IPC: A61F13/02 ,  A61M37/00

Abstract: A transdermal administration device including an administration member including a substrate having first and second surfaces, and a projection protruding from the first surface, a first adhesive sheet adhered to and extending outward from the second surface, a second adhesive sheet adhered to and extending outward from the first adhesive sheet, and a cover including a main body and a flange extending outward from an edge of the main body. The main body and the flange form a structure body including a remaining portion which includes at least a portion of the flange and is configured to remain on the second adhesive sheet, a tear-off portion which includes at least a portion of the main body and is configured to be separated from the remaining portion, and a tear-off assistance portion configured to facilitate formation of a cut for separating the tear-off portion from the remaining portion.

公开(公告)号：US20160325081A1

公开(公告)日：2016-11-10

申请号：US15217306

申请日：2016-07-22

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Hiroyuki KATO

IPC: A61M37/00

Abstract: A microneedle unit includes a microneedle including a facing surface having at least one projection and a support surface opposite to the facing surface, a recessed container having a housing space between an opening and a bottom of the recessed container for housing the microneedle such that the microneedle has the facing surface facing outside of the recessed container through the opening, and an adhering structure having a first contact surface adhered to the bottom of the recessed container and a second contact surface adhered to the support surface of the microneedle. The recessed container is deformable such that the bottom is displaced in the pressing direction, that the at least one projection is displaced in the pressing direction on an outside of the housing space, and that a portion of the second contact surface positioned outside the support surface is pushed toward the outside of the housing space.

Abstract translation: 微针单元包括微针，其包括具有至少一个突出部和与相对表面相对的支撑表面的面对表面;凹陷容器，其具有用于容纳微针的凹入容器的开口和底部之间的容纳空间，使得微针 具有通过开口面朝向凹部容器的外侧的面对面，以及具有粘附到凹部容器的底部的第一接触面和粘附于微针的支撑面的第二接触面的粘接结构。 凹陷的容器是可变形的，使得底部沿按压方向移位，至少一个突起沿着按压方向在容纳空间的外侧移位，并且第二接触表面的位于支撑表面外部的一部分 被推向住宅空间的外部。

公开(公告)号：US20170087346A1

公开(公告)日：2017-03-30

申请号：US15376889

申请日：2016-12-13

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Hiroyuki KATO ,  Hisami UENO

IPC: A61M37/00

Abstract: A microneedle unit including a microneedle having a first surface and a second surface opposite to the first surface, the microneedle being flexible and having one or more projections on the first surface, and a support member connected to the second surface of the microneedle such that the support member supports the microneedle. The support member includes an adhesive portion and a rigid portion connected to the adhesive portion, the adhesive portion is adhesive to skin and extends outside of the second surface in plan view of the second surface, and the rigid portion includes a rigid plate which is more rigid than the adhesive portion and the microneedle.

公开(公告)号：US20160121092A1

公开(公告)日：2016-05-05

申请号：US14992560

申请日：2016-01-11

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Hiroyuki KATO

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053

Abstract: A microneedle unit includes a liquid holder, a microneedle, and a support member. The liquid holder has an enclosure that holds liquid including a substance to be administered. The microneedle has a base body and protrusions extending from the surface of the base body. The protrusions are of a hardness sufficient to pierce the liquid holder. The support member supports the base body in a state such that the microneedle is arranged at a position in which the tips of the protrusions and the enclosure holding the liquid are opposed to each other with a gap provided therebetween. The tips of the protrusions can be displaced to a position where the tips of the protrusions penetrate through the liquid holder in response to an external force applied to the base body.

Abstract translation: 微针单元包括液体保持器，微针和支撑构件。 液体保持器具有容纳包括待施用物质的液体的外壳。 微针具有从基体的表面延伸的基体和突起。 突起具有足以刺穿液体保持器的硬度。 支撑构件以这样的状态支撑基体，使得微针布置在突出体的顶端和保持液体的壳体彼此相对的位置处，其间设置有间隙。 突起的尖端可以移位到突起的尖端响应于施加到基体的外力而穿过液体保持器的位置。

公开(公告)号：US20160081919A1

公开(公告)日：2016-03-24

申请号：US14959228

申请日：2015-12-04

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Hiroyuki KATO

IPC: A61K9/00 ,  A61Q19/00 ,  A61K47/36 ,  A61K38/00 ,  A61K8/02 ,  A61K8/73

CPC classification number: A61K9/0021 ,  A61K8/0204 ,  A61K8/736 ,  A61K38/00 ,  A61K47/36 ,  A61K47/61 ,  A61K2800/91 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61Q19/00

Abstract: An acicular body includes a support base, and a needle formed on the support base and containing a chitosan derivative.

Abstract translation: 针状体包括支撑基部和形成在支撑基底上并包含壳聚糖衍生物的针。

公开(公告)号：US20160038729A1

公开(公告)日：2016-02-11

申请号：US14922970

申请日：2015-10-26

Applicant: TOPPAN PRINTING CO., LTD.

Inventor： Hiroyuki KATO

IPC: A61M37/00 ,  B29C39/02

CPC classification number: A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C39/026 ,  B29C41/12 ,  B29C41/36 ,  B29C41/50 ,  B29L2031/753 ,  B29L2031/756

Abstract: A method for producing an acicular body having a support base and an acicular protrusion on one surface of the support base includes supplying an acicular body-forming liquid, in which an acicular body-forming material is dissolved or dispersed in a solvent, to an intaglio plate having a recess corresponding to a protrusion, under a first pressure environment of not more than 0.05 MPa, changing the first pressure environment of the acicular body-forming liquid supplied to the intaglio plate to a second pressure environment of higher than 0.05 MPa, drying the acicular body-forming liquid supplied to the intaglio plate such that an acicular body is formed, and peeling the acicular body from the intaglio plate.

Abstract translation: 一种在支撑基体的一个表面上具有支撑基体和针状突起的针状体的制造方法包括：将针状体形成液体溶解或分散在溶剂中的针状体形成液体供给到凹版 在不大于0.05MPa的第一压力环境下，具有对应于突起的凹部的板，将供给到凹版的针状体形成液体的第一压力环境改变为高于0.05MPa的第二压力环境，干燥 将针状体形成液供给到凹版，从而形成针状体，并将针状体从凹版上剥离。