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公开(公告)号：US20180345000A1
公开(公告)日：2018-12-06
申请号：US16102427
申请日：2018-08-13
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki KATO
IPC: A61M37/00
CPC classification number: A61M37/00
Abstract: A plurality of projections in a transdermal administration device each include a columnar portion extending from a first surface of a substrate, and a tapered portion extending from a top of the columnar portion. A maximum angle of an apex of the tapered portion viewed in a direction parallel with the first surface is in a range of 10° or more and 30° or less, a ratio of a length from a proximal end to a distal end of the tapered portion to a length from a proximal end to a distal end of the projection as viewed in a direction perpendicular to the first surface is in a range of 0.45 or more and 0.75 or less, and a pitch (distance between centers of closest projections), viewed in a direction perpendicular to the first surface is in a range of 50 μm or more and 350 μm or less.
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公开(公告)号：US20160082626A1
公开(公告)日：2016-03-24
申请号：US14958691
申请日：2015-12-03
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki KATO , Hanae Tagami , Hisami Ueno , Seiji Gunjima , Hiroshi Matsuzawa , Momoko Araki , Shigeki Takahata
CPC classification number: B29C43/021 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , B29C33/424 , B29C39/026 , B29C41/045 , B29C43/146 , B29C43/203 , B29C43/34 , B29C43/3697 , B29C43/52 , B29C2043/025 , B29C2043/026 , B29C2043/3205 , B29C2043/3673 , B29K2105/0035 , B29K2105/0058 , B29K2627/12 , B29K2683/00 , B29K2995/0065 , B29L2031/7544 , B29L2031/756
Abstract: A method of manufacturing an acicular body including a support substrate and a needle formed on the support substrate, includes: supplying a needle forming solution onto an intaglio plate having a recess that has a shape corresponding to the needle; disposing a film on the needle forming solution; compressing the needle forming solution from above the film such that the needle forming solution is moved into the recess; and removing a liquid component from the needle forming solution inside the recess such that the needle forming solution is solidified and that the needle is formed.
Abstract translation: 一种制造针状体的方法，所述针状体包括支撑基板和形成在所述支撑基板上的针，包括：将针状溶液供应到具有与针相对应的形状的凹部的凹版上; 在成针溶液上涂膜; 从膜上方压制针形成溶液，使得针形溶液移入凹槽中; 并且从所述凹部内的针形成溶液中除去液体成分，使得针状溶液固化并形成针。
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公开(公告)号：US20170368322A1
公开(公告)日：2017-12-28
申请号：US15701216
申请日：2017-09-11
Applicant: TOPPAN PRINTING CO., LTD. , JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NAT'L INST. OF INFECTIOUS DISEASES
Inventor： Hiroyuki KATO , Tomoya SUMIDA , Yoshihiro KODAMA , Seishiro NAITO
IPC: A61M37/00
Abstract: A drug administration device includes a substrate having a first surface, a projection extending from the first surface, and a solid drug. One direction that intersects with the first surface is a first direction, and one direction that extends along the first surface is a second direction. A groove serving as a receiving section is formed in the projection. The groove defines a cavity recessed in the first direction toward the substrate and extends in the second direction to open to a section of the peripheral surface of the projection. The drug is received in the groove.
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公开(公告)号：US20170304603A1
公开(公告)日：2017-10-26
申请号：US15647540
申请日：2017-07-12
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki KATO , Ichiro Takase
CPC classification number: A61M37/0015 , A61B17/205 , A61M5/14248 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053
Abstract: A transdermal administration device including a first administration member including a first substrate and a first projection protruding from a first administration surface of the first substrate, and a second administration member including a second substrate and a second projection protruding from a second administration surface of the second substrate. The first substrate has an aperture, and the second substrate is positioned within the aperture when viewed in a direction perpendicular to the second administration surface.
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公开(公告)号：US20160325082A1
公开(公告)日：2016-11-10
申请号：US15217540
申请日：2016-07-22
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki KATO , Toshiyuki SUZUKI
IPC: A61M37/00
CPC classification number: A61M37/0015 , A61M2037/0023 , A61M2037/0046
Abstract: A microneedle unit includes a microneedle having a facing surface that faces a puncture target and an adhering surface opposite to the facing surface, the microneedle having at least one projection formed on the facing surface, a recessed container which houses the microneedle and has an opening that surrounds the microneedle, a cover having a sheet form and being connected to the recessed container, and an adhering structure positioned between the cover and the adhering surface. Upon receiving a force, the recessed container is releasable from the cover with the microneedle being adhered to the cover via the adhering structure. The adhering structure has a first contact surface and a second contact surface. When the projections pierce the puncture target, the second contact surface comes into contact with the puncture target at a position outside the facing surface.
Abstract translation: 微针单元包括具有面向穿刺针的面对面和与面对面相反的粘附面的微针，所述微针具有形成在所述面对面上的至少一个突起，所述凹形容器容纳所述微针，并且具有开口， 围绕微针，具有片状并且连接到凹陷容器的盖，以及位于盖和粘合表面之间的粘合结构。 在接收到力时，凹形容器可从盖子脱离，微针通过粘附结构粘附到盖子上。 粘合结构具有第一接触表面和第二接触表面。 当突起刺穿穿刺目标时，第二接触表面在相对表面外侧的位置与穿刺目标接触。
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Patent Agency Ranking
公开(公告)号：US20160136408A1
公开(公告)日：2016-05-19
申请号：US15003366
申请日：2016-01-21
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki KATO
Abstract: A microneedle includes a substrate, and projections which extend from a surface of the substrate. Each of the projections includes layers separated from each other in a direction in which the projection extends. The layers include a first layer which contains a polymer which is soluble in water and poorly soluble in oil and a second layer which contains a polymer that is soluble in oil. The first layer and the second layer are adjacent to each other and are formed in the order of the first layer and the second layer from the projection to the substrate.
Abstract translation: 微针包括基底和从基底的表面延伸的突起。 每个突起包括在突起延伸的方向上彼此分离的层。 这些层包括含有可溶于水并且难溶于油的聚合物的第一层和含有可溶于油的聚合物的第二层。 第一层和第二层彼此相邻并且从第一层和第二层的顺序从突起到基底形成。
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公开(公告)号：US20140361459A1
公开(公告)日：2014-12-11
申请号：US14470078
申请日：2014-08-27
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki KATO , Takako Yamamoto , Yoshikazu Taroura
CPC classification number: A61M37/0015 , A61K9/0021 , A61K47/12 , A61K47/36 , A61M2037/0046 , A61M2037/0053 , B29C39/003 , B29C41/12 , B29K2005/00 , F04C2270/041
Abstract: A needle-shaped structure includes a needle-shaped projection and a support substrate supporting the projection wherein the projection contains at least a chitosan and an organic acid, places a low burden on a living body and is able to keep the microscopic form after puncture into the skin.
Abstract translation: 针状结构包括针状突起和支撑突起的支撑基板，其中突出部至少包含壳聚糖和有机酸，对活体施加低负担并且能够在穿刺后保持微观形式 皮。
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公开(公告)号：US20170304604A1
公开(公告)日：2017-10-26
申请号：US15647598
申请日：2017-07-12
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki KATO
Abstract: A transdermal administration device packaged body includes a transdermal administration device including an administration member housed in a container, the administration member having at least one projection protruding from a first surface of a substrate, and an outer package which houses the transdermal administration device and has a bag form including a front component and a rear component. The front component is positioned on a first surface side of the substrate, the rear component is positioned on a second surface side opposite to the first surface side of the substrate, and the front component has an opening member configured to be pulled open to open the outer package.
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9.发明申请公开(公告)号：US20170239458A1
公开(公告)日：2017-08-24
申请号：US15589453
申请日：2017-05-08
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki KATO , Ryoichi Asai , Tomoya Sumida
CPC classification number: A61M37/0015 , A61M5/002 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , B29C33/0022 , B29C33/44 , B29C59/02 , B29C59/04 , B29L2031/7544 , B29L2031/756 , B65B9/04
Abstract: A transdermal administration device including an administering part including a substrate having a first surface, and at least one projection protruding from the first surface. The projection has a shape which extends along the first surface and includes one linear top edge which is located away from the first surface and has a first end and a second end, two primary lateral faces which share the one linear top edge and have lateral edges each individually connecting the first surface with the first end, and a secondary lateral face which has the lateral edges in common with the respective two primary lateral faces and forms one corner together with the two primary lateral faces. One of the lateral edge and the top edge on the primary lateral face form an obtuse angle, and the two lateral edges on the secondary lateral face form an acute angle.
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公开(公告)号：US20160213819A1
公开(公告)日：2016-07-28
申请号：US15003457
申请日：2016-01-21
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki KATO , Takako YAMAMOTO
CPC classification number: A61L31/042 , A61M5/00 , A61M37/0015 , A61M2037/0053
Abstract: An acicular body includes a support plate having a brightness of 5.0 or less, and a needle disposed on the support plate. The needle includes a tip formed to pierce a skin and a light transmission area which is located in an area including the tip and has a total light transmittance of 20% or more.
Abstract translation: 针状体包括亮度为5.0以下的支撑板和设置在支撑板上的针。 针包括形成为刺穿皮肤的尖端和位于包括尖端的区域中的透光区域，并且具有20％以上的总透光率。
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