公开(公告)号：US06663859B2

公开(公告)日：2003-12-16

申请号：US09756558

申请日：2001-01-08

申请人： Susan S. Percival ,  Robin J. Henken ,  John St. Cyr ,  Clarence A. Johnson ,  Terri L. Butler

发明人： Susan S. Percival ,  Robin J. Henken ,  John St. Cyr ,  Clarence A. Johnson ,  Terri L. Butler

IPC分类号： A01N6300

CPC分类号： A61K31/7004 ,  A61K31/70 ,  A61K2035/124 ,  A61K2039/515 ,  C12N2500/34 ,  Y10S514/885

摘要： D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration of D-Ribose. Methods are also provided for the enhancement of the immune response in isolated leukocytes. Leukocytes are cultured ex vivo in the presence of D-Ribose and transfused into a patient in need of leukocyte augmentation.

公开(公告)号：US07553817B2

公开(公告)日：2009-06-30

申请号：US10692338

申请日：2003-10-23

申请人： Terri L. Butler ,  John St. Cyr ,  Clarence A. Johnson

发明人： Terri L. Butler ,  John St. Cyr ,  Clarence A. Johnson

IPC分类号： A61K31/70

CPC分类号： A61K45/06 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/195 ,  A61K31/21 ,  A61K31/506 ,  A61K31/519 ,  A61K31/522 ,  A61K31/525 ,  A61K31/70 ,  A61K31/7004 ,  A61K33/06 ,  A61K2300/00 ,  A23V2250/626 ,  A23V2250/61 ,  A23V2250/0606 ,  A23V2250/062 ,  A23V2250/708 ,  A23V2250/706 ,  A23V2250/7052

摘要： The present invention relates to compositions for supplementing the diet of subjects suffering from cardiovascular or peripheral vascular disease or those at risk for such conditions. Ribose is given alone or in combination with one or a combination of vasodilators, nutrients and vitamins. Preferred vitamins include Vitamins C, B6, B12 and folic acid. Preferred nutrients include glutamine and glucose.

摘要翻译： 本发明涉及用于补充患有心血管或外周血管疾病的受试者或具有这种病症风险的受试者饮食的组合物。 单独或与血管扩张剂，营养素和维生素的一种或组合给予核糖。 优选的维生素包括维生素C，B6，B12和叶酸。 优选的营养物质包括谷氨酰胺和葡萄糖。

公开(公告)号：US06339716B1

公开(公告)日：2002-01-15

申请号：US09405462

申请日：1999-09-24

申请人： Stephen G. Sawada ,  John St. Cyr ,  Clarence A. Johnson

发明人： Stephen G. Sawada ,  John St. Cyr ,  Clarence A. Johnson

IPC分类号： A61B505

CPC分类号： A61K49/0004 ,  A61K49/226 ,  A61K51/02 ,  A61K51/04

摘要： A method of determining the viability of a hibernating or stunned myocardial segment comprises the administration of ribose, a vasodilator and an inotropic agent. The preferred agent is dobutamine, which has both a vasodilation and an inotropic effect. The segments may be identified by myocardial imaging by any known means, such as echocardiography, Thallium-201 tracing or positron emission tomography. Ribose is preferably given one minute to three hours prior to administration of the vasodilator and inotropic agents.

摘要翻译： 确定冬眠或昏迷的心肌节段的活力的方法包括施用核糖，血管扩张剂和变力剂。 优选的药物是多巴酚丁胺，其具有血管舒张和变力作用。 可以通过任何已知的手段，例如超声心动图，铊-201跟踪或正电子发射断层扫描，通过心肌成像来鉴定节段。 优选在施用血管扩张剂和变力剂之前1分钟至3小时给予核糖。

公开(公告)号：US6159942A

公开(公告)日：2000-12-12

申请号：US290789

申请日：1999-04-12

申请人： John St. Cyr ,  Clarence A. Johnson

发明人： John St. Cyr ,  Clarence A. Johnson

IPC分类号： A61K31/7004 ,  A61K33/06 ,  A61P3/00 ,  A61P43/00 ,  A61K31/70

CPC分类号： A61K31/7004 ,  A61K31/197 ,  A61K31/198 ,  A61K33/06 ,  A61K31/195 ,  A61K31/205 ,  A61K2300/00

摘要： Precursors of adenosine triphosphate are administered orally to increase intracellular ATP concentration as dietary supplements or for treatment of reduced energy availability resulting from strenuous physical activity, illness or trauma. Pentose sugars are administered individually, mixed into dry food or in solution. The preferred pentose is D-ribose, singly or combined with creatine, pyruvate, L-carnitine and/or vasodilating agents. Additionally, magnesium, electrolytes, fatty acids and hexose sugars can be used. The compositions and methods of this invention are especially beneficial to mammals having reduced energy availability or high energy demand.