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公开(公告)号:US20090312383A1
公开(公告)日:2009-12-17
申请号:US11919435
申请日:2006-04-26
申请人: Kazuyoshi Aso , Michiyo Mochizuki , Albert Charles Gyorkos , Christopher Peter Corrette , Suk Young Cho , Scott Alan Pratt , Christopher Stephen Siedem
发明人: Kazuyoshi Aso , Michiyo Mochizuki , Albert Charles Gyorkos , Christopher Peter Corrette , Suk Young Cho , Scott Alan Pratt , Christopher Stephen Siedem
IPC分类号: A61K31/4184 , C07D235/14 , C07D403/06 , A61P25/00 , A61P25/24 , A61P25/22
CPC分类号: C07D403/04 , C07D235/26 , C07D235/30 , C07D335/02 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/04 , C07D417/10 , C07D471/04 , C07D471/06 , C07D495/04
摘要: There is provided a CRF receptor antagonist comprising a compound of the formula (I): wherein R1 is an optionally substituted hydrocarbyl, an optionally substituted C-linked heterocyclic group, an optionally substituted N-linked heteroaryl group, a cyano or an acyl; R2 is an optionally substituted cyclic hydrocarbyl or an optionally substituted heterocyclic group; X is oxygen, sulfur or —NR3— (wherein R3 is a hydrogen, an optionally substituted hydrocarbyl or an acyl); Y1, Y2 and Y3 are each an optionally substituted carbon or a nitrogen, provided that one or less of Y1, Y2 and Y3 is nitrogen; and Z is a bond, —CO—, oxygen, sulfur, —SO—, —SO2—, —NR4—, —NR4-alk-, —CONR4— or —NR4CO— (wherein alk is an optionally substituted C1-4 alkylene and R4 is a hydrogen, an optionally substituted hydrocarbyl or an acyl); or a salt thereof or a prodrug thereof.
摘要翻译: 提供了包含式(I)化合物的CRF受体拮抗剂:其中R1是任选取代的烃基,任选取代的C连接的杂环基,任选取代的N-连接的杂芳基,氰基或酰基; R2是任选取代的环状烃基或任选取代的杂环基; X是氧,硫或-NR 3 - (其中R 3是氢,任选取代的烃基或酰基); Y1,Y2和Y3各自为任选取代的碳或氮,条件是Y1,Y2和Y3中的一个或多个为氮; 并且Z是键,-CO-,氧,硫,-SO - , - SO 2 - , - NR 4 - , - NR 4 - 烷 - , - CONR 4 - 或-NR 4 CO-(其中,alk是任选取代的C 1-4亚烷基 和R4是氢,任选取代的烃基或酰基); 或其盐或其前药。