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1.
公开(公告)号:US20180291015A1
公开(公告)日:2018-10-11
申请号:US16007532
申请日:2018-06-13
申请人: vTv Therapeutics LLC
发明人: Adnan M.M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
IPC分类号: C07D417/12 , C07D513/04 , C07D235/30 , A61K31/437 , A61K31/428 , A61K31/4168 , C07D471/04 , C07D417/14 , A61K31/4188
CPC分类号: C07D417/12 , A61K31/4168 , A61K31/4188 , A61K31/428 , A61K31/437 , C07D235/30 , C07D417/14 , C07D471/04 , C07D513/04
摘要: Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.
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公开(公告)号:US20180222870A1
公开(公告)日:2018-08-09
申请号:US15748014
申请日:2016-07-22
发明人: Heiko SCHIRMER
IPC分类号: C07D235/30 , A61P35/00
CPC分类号: C07D235/30 , A61P35/00
摘要: The present invention relates to the adduct (2E)-but-2-enedioic acid-3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-yl)propanoic acid (1:4), methods for preparing this adduct, pharmaceutical compositions comprising this adduct and also the use of this adduct for preparing a medicament for the treatment of a disease.
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公开(公告)号:US20180148419A1
公开(公告)日:2018-05-31
申请号:US15879792
申请日:2018-01-25
发明人: Lynn RESNICK , George T. TOPALOV , Justin K. BELARDI , James S. HALE , Scott S. HARRIED , Charles A. FLENTGE , David A. MARESKA
IPC分类号: C07D235/30 , C07D401/12 , C07D403/04 , C07D405/12 , C07D413/04 , C07D401/04
CPC分类号: C07D235/30 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D413/04
摘要: Optionally substituted benzoimidazol-1,2-yl amides, such as compounds of Formula 1 or Formula 2, can be used to treat disorders associated with a Kv7 potassium channel activator. Compositions, medicaments, and dosage forms related to the treatment are also disclosed herein.
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公开(公告)号:US09969710B2
公开(公告)日:2018-05-15
申请号:US15267606
申请日:2016-09-16
申请人: Merck Patent GmbH
发明人: Catherine Jorand-Lebrun , Ruoxi Lan , Austin Chen , Ryan C. Clark
IPC分类号: A61K31/4439 , A61K31/506 , A61K31/4184 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04 , C07D451/02 , C07D235/30 , C07D471/08
CPC分类号: C07D401/04 , A61K31/4184 , A61K31/4439 , A61K31/506 , C07D235/30 , C07D403/04 , C07D405/04 , C07D413/04 , C07D451/02 , C07D471/08
摘要: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
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公开(公告)号:US20180044282A1
公开(公告)日:2018-02-15
申请号:US15688732
申请日:2017-08-28
发明人: Kenneth W. Bair , Nicholas Barczak , Bingsong Han , David R. Lancia, JR. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Mary Margaret Zablocki , Xiaozhang Zheng
IPC分类号: C07C259/06 , C07D471/04 , C07D417/04 , C07D241/08 , C07D213/56 , C07D233/68 , C07D235/14 , C07D487/10 , C07D471/10 , C07D295/155 , C07D209/44 , A61K31/5377 , A61K31/4439 , A61K31/495 , A61K31/44 , A61K31/417 , A61K31/4184 , A61K31/397 , C07D495/10 , A61K31/407 , A61K31/435 , A61K31/451 , A61K31/4035 , A61K31/277 , A61K31/438 , C07D221/20 , A61K31/185 , C07D307/68 , C07D213/65 , C07D295/192 , C07D211/58 , C07D211/16 , C07D513/10 , C07D209/46 , C07D209/42 , C07D277/56 , C07D209/08 , C07D498/04 , C07D207/267 , C07D493/08 , C07D207/10 , C07D491/10 , C07D487/08 , C07D487/04 , C07D261/18 , C07D257/04 , C07D249/18 , C07D417/12 , C07D241/12 , C07D409/12 , C07D409/04 , C07D405/12 , C07D239/22 , C07D239/20 , C07D235/30 , C07D401/12 , C07D401/04 , C07D333/70 , C07D233/38 , C07D233/36 , C07D231/18 , C07D231/14 , C07D317/68 , C07D215/12 , C07D213/81 , C07D213/75 , C07D401/14
CPC分类号: C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10 , Y02A50/393 , Y02A50/411 , Y02A50/481
摘要: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.
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公开(公告)号:US20170327512A1
公开(公告)日:2017-11-16
申请号:US15418579
申请日:2017-01-27
发明人: Edward Roberts , Gopi Kumar Mittapalli , Yuanhua Wang , Jun Yang , Marion Toussaint , Olga Habarova , Hugh Rosen
IPC分类号: C07D491/107 , C07D207/16 , C07D417/14 , C07D413/14 , C07D413/06 , C07D409/14 , C07D409/06 , C07D405/14 , C07D401/14 , C07D401/12 , C07D401/06 , C07D401/04 , C07D307/14 , C07D295/205 , C07D295/20 , C07D277/82 , C07D267/20 , C07D263/58 , C07D249/08 , C07D241/54 , C07D241/44 , C07D239/94 , C07D239/42 , C07D235/30 , C07D213/74 , C07D211/62 , C07D498/10 , C07D519/00
CPC分类号: C07D491/107 , C07D207/16 , C07D211/62 , C07D213/74 , C07D235/30 , C07D239/42 , C07D239/94 , C07D241/44 , C07D241/54 , C07D249/08 , C07D263/58 , C07D267/20 , C07D277/82 , C07D295/20 , C07D295/205 , C07D307/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D498/10 , C07D519/00
摘要: Compounds comprising piperazines, piperidines, spiro-furanopiperidines, and analogs thereof are provided that are modulators, such as positive allosteric modulators, of one or more subclasses of vasopressin receptors. The compounds can be selective modulators of one or more subclasses of vasopressin receptors. Compounds of the invention can be used in the treatment of a condition wherein modulating a vasopressin receptor is medically indicated for treatment of the condition.
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7.
公开(公告)号:US09795140B2
公开(公告)日:2017-10-24
申请号:US15092646
申请日:2016-04-07
申请人: Dow AgroSciences LLC
发明人: Timothy P. Martin , Joseph D. Eckelbarger , Ronald Ross, Jr. , Kyle DeKorver , Ronald J. Heemstra , Daniel I. Knueppel , Peter Vednor , Ricky Hunter , David A. Demeter , Tony K. Trullinger , Erich Baum , Zoltan Benko , Nakyen Choy , Gary Crouse , John F. Daeuble, Sr. , Fangzheng Li , Jeff Nissen , Michelle Riener , Tom Sparks , Frank Wessels , Maurice Yap
IPC分类号: A01N53/00 , A01N43/90 , C07D207/273 , A01N43/82 , C07D307/33 , C07D277/36 , C07D263/26 , C07D261/12 , C07D333/48 , C07D307/52 , C07D277/30 , C07D213/56 , C07C237/22 , C07D333/60 , C07D233/80 , C07D487/04 , A01N43/707 , A01N43/653 , A01N43/60 , A01N43/40 , A01N41/10 , A01N37/34 , A01N37/22 , C07D253/07 , C07D241/20 , C07C317/14 , C07C233/65 , C07C233/63 , C07D209/49 , C07C381/10 , C07D205/04 , C07C237/42 , C07D207/10 , C07D207/452 , C07C255/29 , C07C255/57 , C07D285/06 , C07D295/32 , C07D305/08 , C07C255/46 , C07D213/75 , C07C255/60 , C07C259/10 , C07D213/81 , C07D213/84 , C07D309/14 , C07D213/89 , C07D215/227 , C07C271/28 , C07C271/66 , C07D231/12 , C07D331/04 , C07D231/56 , C07D333/36 , C07D233/36 , C07C311/08 , C07C311/46 , C07D235/30 , C07C317/28 , C07C317/40 , C07C317/50 , C07C323/41 , C07C323/42 , C07C323/59 , C07D249/08 , C07C331/12 , C07D215/38
CPC分类号: A01N53/00 , A01N37/22 , A01N37/34 , A01N41/10 , A01N43/40 , A01N43/60 , A01N43/653 , A01N43/707 , A01N43/82 , A01N43/90 , C07C233/63 , C07C233/65 , C07C237/22 , C07C237/42 , C07C255/29 , C07C255/46 , C07C255/57 , C07C255/60 , C07C259/10 , C07C271/28 , C07C271/66 , C07C311/08 , C07C311/46 , C07C317/14 , C07C317/28 , C07C317/40 , C07C317/50 , C07C323/41 , C07C323/42 , C07C323/59 , C07C331/12 , C07C381/10 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/10 , C07D207/273 , C07D207/452 , C07D209/49 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/227 , C07D215/38 , C07D231/12 , C07D231/56 , C07D233/36 , C07D233/80 , C07D235/30 , C07D241/20 , C07D249/08 , C07D253/07 , C07D261/12 , C07D263/26 , C07D277/30 , C07D277/36 , C07D285/06 , C07D295/32 , C07D305/08 , C07D307/33 , C07D307/52 , C07D309/14 , C07D331/04 , C07D333/36 , C07D333/48 , C07D333/60 , C07D487/04
摘要: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
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公开(公告)号:US20170297355A1
公开(公告)日:2017-10-19
申请号:US15515622
申请日:2015-09-30
发明人: Takaaki Kurata , Kyohei Miyanaga
IPC分类号: B41M5/333 , C07D235/30 , C07C311/05 , C07C275/40 , C07D277/42 , C07C321/30 , C07C2601/14
CPC分类号: B41M5/3333 , B41M5/3275 , B41M5/3335 , B41M5/3336 , B41M2205/04 , C07C275/40 , C07C311/05 , C07C321/30 , C07C2601/14 , C07D235/30 , C07D277/42
摘要: This heat-sensitive recording material is configured to contain, as a color-developing compound, at least one compound represented by one of formulas (1)-(3):
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公开(公告)号:US20170197921A1
公开(公告)日:2017-07-13
申请号:US15118154
申请日:2015-02-10
发明人: Hartmut REHWINKEL , Olaf PANKNIN , Sven RING , Sonja ANLAUF , Holger SIEBENEICHER , Duy NGUYEN , Wolfgang SCHWEDE , Marcus BAUSER , Katja ZIMMERMANN , Stefan KAULFUSS , Roland NEUHAUS , Paul Matthew BLANEY
IPC分类号: C07D235/30 , A61K31/4439 , C07D401/12 , A61K31/4184 , A61K45/06
CPC分类号: C07D235/30 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/12
摘要: The present invention relates to benzimidazol-2-amines of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
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10.
公开(公告)号:US20170166563A1
公开(公告)日:2017-06-15
申请号:US15327560
申请日:2015-07-31
发明人: JAESEUNG KIM , SEOHYUN AHN , YEEJIN JEON , DONGSIK PARK , YOUNG-IN YANG , DOOHYUNG LEE , SAEYEON LEE , JIYE AHN , JEONGJUN KIM , KIYEAN NAM , SUNHEE KANG , MINJUNG SEO , MOOYOUNG SEO , JEONGJEA SEO , SUNG-JUN HAN , JUNG HWAN KIM , SANGCHUL LEE , GAHEE CHOI , YUNMI LEE
IPC分类号: C07D471/04 , C07D401/12 , C07D403/12 , C07D235/30 , C07D403/04 , C07D405/12 , C07D401/04 , C07D405/14 , C07D401/14 , C07D413/14 , C07D401/06 , C07D409/14 , C07D417/14 , C07D403/14 , C07D413/12
CPC分类号: C07D471/04 , C07D235/20 , C07D235/30 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要: The present invention relates to benzimidazole derivatives having the general formula I, wherein n is 0 or 1; X1 and X2 are independently, at each occurrence, CR5 or N; Y is C1-C6 alkylene, wherein alkylene is optionally substituted with one to two C1-C3 alkyl groups; R1 is selected from the group consisting of hydrogen, halogen, C1-C6 alkoxy, —NH2, —NHR6, —NR7R8 and —NH—(R9)n—R10, n being 0 or 1; R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, —NH2, —NHR6, —NR7R8 and —NH—(R9)n—R10; R3 is selected from the group consisting of hydrogen, hydroxyl, OR11, —NR7R8, C1-C6 alkoxy, C1-C6 alkyl, C3- C10 cycloalkyl, C1-C3 haloalkyl, —C(O)NHR11, aryl, heteroaryl and heterocyclyl, wherein each of said cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally and independently substituted with one to four Ra groups; and R4 is selected from the group consisting of —NH2, —N(R12)(V)pR13, —NH(V)p—OR14, —NHC(O)R15, and groups of formula 1a shown below, and their use in the treatment of diseases, in particular inflammatory diseases, cancer, stroke and/or Alzheimer's disease.
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