公开(公告)号：US20090130023A1

公开(公告)日：2009-05-21

申请号：US12066510

申请日：2006-09-07

申请人： Hannes Dahnke ,  Tobias Schaeffter

发明人： Hannes Dahnke ,  Tobias Schaeffter

IPC分类号： A61K49/06 ,  G01V3/00

CPC分类号： A61B5/055 ,  A61B6/481 ,  A61K49/1818 ,  B82Y5/00 ,  G01R33/50 ,  G01R33/5601 ,  G01R33/56366

摘要： MRI based molecular imaging is strongly supported by the accurate quantification of contrast agents. According to an exemplary embodiment of the present invention, contrast agent is applied on the basis of a multiple injection application scheme, during which changes in relaxation rate are determined. This may provide for an accurate determination of tumor vascularity via MRI relaxometry.

摘要翻译： 通过造影剂的准确定量强烈支持基于MRI的分子成像。 根据本发明的示例性实施方案，在多次注射施用方案的基础上应用造影剂，在此期间确定松弛率的变化。 这可以通过MRI弛豫测定来准确地确定肿瘤血管。

公开(公告)号：US08423119B2

公开(公告)日：2013-04-16

申请号：US12089716

申请日：2006-09-15

申请人： Sascha Krueger ,  Tobias Schaeffter

发明人： Sascha Krueger ,  Tobias Schaeffter

IPC分类号： A61B5/055

CPC分类号： G01R33/286 ,  A61B2090/363 ,  A61B2090/3954

摘要： A fiducial marker assembly (30) is tracked using a magnetic resonance scanner (10). At the tracked position of the fiducial marker assembly, local B0 magnetic field inhomogeneity is measured. A warning is issued if the measured local B0 magnetic field inhomogeneity satisfies a warning criterion. A noise figure of merit of the tracking is also determined, and the warning is also issued if the noise figure of merit satisfies a noise-based warning criterion.

摘要翻译： 使用磁共振扫描器（10）跟踪基准标记组件（30）。 在基准标记组件的跟踪位置，测量局部B0磁场不均匀性。 如果测量的局部B0磁场不均匀性满足警告标准，则发出警告。 还确定了跟踪的噪声因数，并且如果噪声因子值满足基于噪声的警告标准，则也发出警告。

公开(公告)号：US20100156415A1

公开(公告)日：2010-06-24

申请号：US12295938

申请日：2007-03-30

申请人： Jochem Keupp ,  Rolf Lamerichs ,  Tobias Schaeffter

发明人： Jochem Keupp ,  Rolf Lamerichs ,  Tobias Schaeffter

IPC分类号： G01R33/48 ,  G06K9/00

CPC分类号： G01R33/485

摘要： MRI device arranged to a) generate a series of MR echo signals from a nuclear spin series having two or more spectral lines by subjecting at least part of a body (7) to an MR imaging pulse sequence using multiple time-encoding echo time values, b) acquire the MR echo signals for reconstructing a series of time-encoded MR images therefrom, each time-encoded MR image being associated with one of the time-encoding echo time values, c) transform the series of time-encoded MR images into a series of spectral domain MR images on a pixel-by-pixel or voxel-by-voxel basis, d) and superimpose the MR images for obtaining a final image the device being further arranged to apply a time-encoding scheme in step a) such that each spectral line of the nuclear spin species is uniquely mapped to one MR image from the series of spectral domain MR images.

摘要翻译： MRI装置，其被布置为a）通过使用多个时间编码回波时间值对身体（7）的至少一部分进行MR成像脉冲序列，从具有两个或更多个谱线的核自旋序列生成一系列MR回波信号， b）获取用于重构一系列时间编码的MR图像的MR回波信号，每个时间编码的MR图像与时间编码回波时间值之一相关联，c）将一系列时间编码的MR图像变换成 以逐像素或体素为基础的一系列光谱域MR图像，d）并叠加用于获得最终图像的MR图像，所述装置进一步被布置为在步骤a）中应用时间编码方案， 使得核自旋物种的每个谱线被唯一映射到来自一系列频域MR图像的一个MR图像。

公开(公告)号：US20100002926A1

公开(公告)日：2010-01-07

申请号：US12522396

申请日：2008-01-15

申请人： Hannes Dahnke ,  Tobias Schaeffter ,  Peter Van Der Meulen

发明人： Hannes Dahnke ,  Tobias Schaeffter ,  Peter Van Der Meulen

IPC分类号： G06K9/00

CPC分类号： G01R33/56536 ,  G01R33/243 ,  G01R33/281 ,  G01R33/286 ,  G01R33/3875 ,  G01R33/48 ,  G01R33/5601

摘要： The invention relates to a device for magnetic resonance imaging of a body (7). The device (1) comprises means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. In accordance with the invention, the device is arranged to a) generate a series of MR echo signals (20) by subjecting at least a portion of the body (7) to an MR imaging sequence of RF pulses and switched magnetic field gradients, b) acquire the MR echo signals for reconstructing an MR image data set (21) therefrom, c) calculate a gradient map (22) by computing echo shift parameters (SPx, SPy, SPz) from subsets of the MR image data set, the echo shift parameters (SPx, SPy, SPz) indicating magnetic field gradient induced shifts of the echo positions in k-space, wherein each subset comprises a number (n) of spatially adjacent pixel or voxel values of the MR image data set (21).

摘要翻译： 本发明涉及一种用于身体（7）的磁共振成像的装置。 装置（1）包括用于在检查体积中建立基本均匀的主磁场的装置（2），用于产生叠加在主磁场上的开关磁场梯度的装置（3,4,5），用于辐射的装置（6） 朝向身体的射频脉冲（7），用于控制磁场梯度和RF脉冲的产生的控制装置（12），用于接收和采样磁共振信号的装置（10）和用于形成MR图像的重构装置（14） 从信号样本。 根据本发明，该装置被设置成：a）通过使身体（7）的至少一部分经受RF脉冲和切换的磁场梯度的MR成像序列来产生一系列MR回波信号（20），b 获取用于重建MR图像数据集（21）的MR回波信号，c）通过从MR图像数据集的子集计算回波移位参数（SPx，SPy，SPz）来计算梯度图（22），回波 指示在k空间中回波位置的磁场梯度引起的移位的移位参数（SPx，SPy，SPz），其中每个子集包括MR图像数据集（21）的空间相邻像素的数量（n）或体素值。

公开(公告)号：US20080228064A1

公开(公告)日：2008-09-18

申请号：US12089716

申请日：2006-09-15

申请人： Sascha Krueger ,  Tobias Schaeffter

发明人： Sascha Krueger ,  Tobias Schaeffter

IPC分类号： A61B5/055

CPC分类号： G01R33/286 ,  A61B2090/363 ,  A61B2090/3954

摘要： A fiducial marker assembly (30) is tracked using a magnetic resonance scanner (10). At the tracked position of the fiducial marker assembly, local B0 magnetic field inhomogeneity is measured. A warning is issued if the measured local B0 magnetic field inhomogeneity satisfies a warning criterion. A noise figure of merit of the tracking is also determined, and the warning is also issued if the noise figure of merit satisfies a noise-based warning criterion.

摘要翻译： 使用磁共振扫描器（10）跟踪基准标记组件（30）。 在基准标记组件的跟踪位置，测量局部B0磁场不均匀性。 如果测量的局部B0磁场不均匀性满足警告标准，则发出警告。 还确定了跟踪的噪声因数，并且如果噪声因子值满足基于噪声的警告标准，则也发出警告。

公开(公告)号：US10154797B2

公开(公告)日：2018-12-18

申请号：US13450928

申请日：2012-04-19

申请人： Hannes Dahnke ,  Tobias Schaeffter

发明人： Hannes Dahnke ,  Tobias Schaeffter

IPC分类号： A61B5/055 ,  A61B5/00 ,  A61B6/00 ,  A61K49/18 ,  B82Y5/00 ,  G01R33/56 ,  G01R33/563 ,  G01R33/50

摘要： MRI based molecular imaging is strongly supported by the accurate quantification of contrast agents. According to an exemplary embodiment of the present invention, contrast agent is applied on the basis of a multiple injection application scheme, during which changes in relaxation rate are determined. This may provide for an accurate determination of rumor vascularity via MRI relaxometry.

公开(公告)号：US08306603B2

公开(公告)日：2012-11-06

申请号：US11912674

申请日：2006-04-25

申请人： Nicolaas Petrus Willard ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell ,  Tobias Schaeffter ,  Rudolf Mathias Johannes Nicolaas Lamerichs

发明人： Nicolaas Petrus Willard ,  Rene Theodorus Wegh ,  Jeroen Alphons Pikkemaat ,  Holger Gruell ,  Tobias Schaeffter ,  Rudolf Mathias Johannes Nicolaas Lamerichs

IPC分类号： A61B5/05

CPC分类号： G01R33/5601 ,  A61K49/124 ,  G01R33/5605

摘要： The present invention provides a method MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts.

摘要翻译： 本发明提供一种MRI成像方法。 通过对MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致对比度增强区域中具有改善的信噪比的图像，强烈地抑制未增强区域中的不需要的信号，并且减少 人造物，如运动文物。

公开(公告)号：US07855558B2

公开(公告)日：2010-12-21

申请号：US12295938

申请日：2007-03-30

申请人： Jochem Keupp ,  Rolf Lamerichs ,  Tobias Schaeffter

发明人： Jochem Keupp ,  Rolf Lamerichs ,  Tobias Schaeffter

IPC分类号： G01V3/00

CPC分类号： G01R33/485

摘要： MRI device arranged to a) generate a series of MR echo signals from a nuclear spin series having two or more spectral lines by subjecting at least part of a body (7) to an MR imaging pulse sequence using multiple time-encoding echo time values, b) acquire the MR echo signals for reconstructing a series of time-encoded MR images therefrom, each time-encoded MR image being associated with one of the time-encoding echo time values, c) transform the series of time-encoded MR images into a series of spectral domain MR images on a pixel-by-pixel or voxel-by-voxel basis, d) and superimpose the MR images for obtaining a final image the device being further arranged to apply a time-encoding scheme in step a) such that each spectral line of the nuclear spin species is uniquely mapped to one MR image from the series of spectral domain MR images.

摘要翻译： MRI装置，其被布置为a）通过使用多个时间编码回波时间值对身体（7）的至少一部分进行MR成像脉冲序列，从具有两个或更多个谱线的核自旋序列生成一系列MR回波信号， b）获取用于重构一系列时间编码的MR图像的MR回波信号，每个时间编码的MR图像与时间编码回波时间值之一相关联，c）将一系列时间编码的MR图像变换成 以逐像素或体素为基础的一系列光谱域MR图像，d）并且叠加用于获得最终图像的MR图像，所述装置进一步被布置为在步骤a）中应用时间编码方案， 使得核自旋物种的每个谱线被唯一映射到来自一系列频域MR图像的一个MR图像。

公开(公告)号：US20090131781A1

公开(公告)日：2009-05-21

申请号：US12297533

申请日：2007-04-02

申请人： Hannes Dahnke ,  Tobias Schaeffter

发明人： Hannes Dahnke ,  Tobias Schaeffter

IPC分类号： A61B5/055

CPC分类号： G01R33/286 ,  G01R33/3875 ,  G01R33/48 ,  G01R33/56536

摘要： The invention relates to a device for magnetic resonance imaging of a body (7). The device (1) comprises means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. In accordance with the invention, the device is arranged to a) generate a series of MR echo signals (20) by subjecting at least a portion of the body (7) to an MR imaging sequence of RF pulses and switched magnetic field gradients, b) acquire the MR echo signals for reconstructing an MR image data set (21) therefrom, c) calculate a gradient map (22) by computing echo shift parameters (SPx, SPy, SPz) from subsets of the MR image data set, the echo shift parameters (SPx, SPy, SPz) indicating magnetic field gradient induced shifts of the echo positions in k-space, wherein each subset comprises a number (n) of spatially adjacent pixel or voxel values of the MR image data set (21).

摘要翻译： 本发明涉及一种用于身体（7）的磁共振成像的装置。 装置（1）包括用于在检查体积中建立基本均匀的主磁场的装置（2），用于产生叠加在主磁场上的开关磁场梯度的装置（3,4,5），用于辐射的装置（6） 朝向身体的射频脉冲（7），用于控制磁场梯度和RF脉冲的产生的控制装置（12），用于接收和采样磁共振信号的装置（10）和用于形成MR图像的重构装置（14） 从信号样本。 根据本发明，该装置被设置成：a）通过使身体（7）的至少一部分经受RF脉冲和切换的磁场梯度的MR成像序列来产生一系列MR回波信号（20），b 获取用于重建MR图像数据集（21）的MR回波信号，c）通过从MR图像数据集的子集计算回波移位参数（SPx，SPy，SPz）来计算梯度图（22），回波 指示在k空间中回波位置的磁场梯度引起的移位的移位参数（SPx，SPy，SPz），其中每个子集包括MR图像数据集（21）的空间相邻像素的数量（n）或体素值。

公开(公告)号：US20090111140A1

公开(公告)日：2009-04-30

申请号：US12295386

申请日：2007-03-22

申请人： Wei Liu ,  Hannes Dahnke ,  Tobias Schaeffter

发明人： Wei Liu ,  Hannes Dahnke ,  Tobias Schaeffter

IPC分类号： C12Q1/02 ,  C12M1/34

CPC分类号： A61K49/1896 ,  A61K49/1866 ,  B82Y5/00

摘要： The present disclosure is directed to a new technique for MR measurement of ultrashort T2* relaxation utilizing spin-echo acquisition. The ultrashort T2* relaxometry can be used for the quantification of highly concentrated iron labeled cells in cell trafficking and therapy. In an exemplary embodiment, a signal is induced by a low flip angle RF pulse. Following excitation pulse, a gradient readout is applied to form an echo. The time between the RF pulse and the center of the gradient readout is defined as TE. In tissues with highly concentrated iron labeled cells, T2* could be below 1 millisecond. Therefore, the signal can be decayed to a noise level with an echo time of a couple milliseconds. Because T2 is much longer in SPIO labeled cells, the signal acquired by spin echo is much bigger than that from the gradient echo, thus avoiding the negative effects associated with the massive signal loss in the image. The ultrashort T2* relaxation map can then by overlaid on the regular T2* map to generate the final T2* map of the field of view.

摘要翻译： 本公开涉及一种利用自旋回波采集的超短T2 *弛豫的MR测量的新技术。 超短T2 *松弛测定可用于定量细胞运输和治疗中高度浓缩的铁标记细胞。 在示例性实施例中，信号由低翻转RF脉冲引起。 在激发脉冲之后，应用梯度读数以形成回波。 RF脉冲与梯度读数中心之间的时间定义为TE。 在具有高浓度铁标记细胞的组织中，T2 *可能低于1毫秒。 因此，信号可以衰减到具有几毫秒的回波时间的噪声水平。 因为T2在SPIO标记的细胞中长得多，所以通过自旋回波获取的信号要比梯度回波大得多，因此避免了与图像中大量信号丢失相关的负面影响。 然后可以将超短T2 *弛豫图覆盖在常规T2 *图上，以产生视场的最终T2 *图。