公开(公告)号：US5827723A

公开(公告)日：1998-10-27

申请号：US972890

申请日：1992-11-06

申请人： Shuzo Matsushita

发明人： Shuzo Matsushita

IPC分类号： A61K39/21 ,  A61K38/00 ,  A61K39/395 ,  A61P31/12 ,  C07K16/08 ,  C07K16/10 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53

CPC分类号： C07K16/1063 ,  A61K38/00

摘要： The present invention relates to monoclonal antibody 0.5.beta. which binds to an epitope located within the region of amino acids 308-331 of HTLVIIIB gp120 and is capable of substantially neutralising the activity of human immunodeficiency viruses, to a hybridoma which produces the 0.5.beta. antibody, to processes for preparing them and to compositions containing an effective amount of the antibody.

摘要翻译： 本发明涉及与位于HTLVIIIB gp120的氨基酸308-331区域内的表位并且能够基本上中和人免疫缺陷病毒的活性的单克隆抗体0.5β产生0.5β抗体的杂交瘤， 制备它们的方法和含有有效量的抗体的组合物。

公开(公告)号：US08722861B2

公开(公告)日：2014-05-13

申请号：US12743442

申请日：2008-11-19

申请人： Shuzo Matsushita ,  Kazuhisa Yoshimura

发明人： Shuzo Matsushita ,  Kazuhisa Yoshimura

IPC分类号： C07K16/00 ,  A61K39/42

CPC分类号： C07K16/1045 ,  A61K2039/505 ,  A61K2039/507

摘要： The present invention provides a monoclonal antibody that recognizes the V3 loop of the envelope glycoprotein gp120 of AIDS virus, which is any one selected from the following antibodies: (a) an antibody having the amino acid sequence shown in SEQ ID NO: 1 as the amino acid sequence of a H chain variable region (VH), and having the amino acid sequence shown in SEQ ID NO: 2 as the amino acid sequence of a L chain variable region (VL); and (b) an antibody having the amino acid sequence shown in SEQ ID NO: 3 as the amino acid sequence of a H chain variable region (VH), and having the amino acid sequence shown in SEQ ID NO: 4 as the amino acid sequence of a L chain variable region (VL).

摘要翻译： 本发明提供识别AIDS病毒的包膜糖蛋白gp120的V3环的单克隆抗体，其是选自以下抗体中的任一种：（a）具有SEQ ID NO：1所示的氨基酸序列的抗体作为 具有H链可变区（VH）的氨基酸序列，并且具有SEQ ID NO：2所示的氨基酸序列作为L链可变区（VL）的氨基酸序列; 和（b）具有SEQ ID NO：3所示的氨基酸序列的抗体作为H链可变区（VH）的氨基酸序列，并且具有SEQ ID NO：4所示的氨基酸序列作为氨基酸 L链可变区（VL）的序列。

公开(公告)号：US5712373A

公开(公告)日：1998-01-27

申请号：US253030

申请日：1994-06-02

申请人： Yasuyuki Eda ,  Kiyoshi Osatomi ,  Kouichi Shiosaki ,  Sachio Tokiyoshi ,  Shuzo Matsushita ,  Toshio Hattori ,  Kiyoshi Takatsuki

发明人： Yasuyuki Eda ,  Kiyoshi Osatomi ,  Kouichi Shiosaki ,  Sachio Tokiyoshi ,  Shuzo Matsushita ,  Toshio Hattori ,  Kiyoshi Takatsuki

IPC分类号： A61K38/00 ,  C07K16/10 ,  C12N5/20

CPC分类号： C07K16/1063 ,  A61K38/00

摘要： A murine monoclonal antibody which specifically binds to a glycoprotein antigen having a molecular weight of about 12.times.10.sup.4 daltons (gp120) present in the envelope of human T-lymphotropic virus III.sub.MN (HTLV-III.sub.MN) and capable of neutralizing the HTLV-III.sub.MN as determined by in vitro inhibition of syncytium formation but does not bind to other HTLV-III strains, or antigen-binding fragments, which is useful for prophylaxis, treatment and diagnosis of AIDS.

摘要翻译： 特异性结合存在于人T淋巴细胞病毒IIIMN（HTLV-IIIMN）包膜中的分子量为约12×10 4道尔顿（gp120）的糖蛋白抗原并能够中和HTLV-IIIMN的鼠单克隆抗体， 合胞体形成的体外抑制，但不结合其他可用于预防，治疗和诊断艾滋病的HTLV-III毒株或抗原结合片段。

公开(公告)号：US4862206A

公开(公告)日：1989-08-29

申请号：US186756

申请日：1988-04-26

申请人： Hiroshi Ootsuka ,  Shinji Tominaga ,  Haruo Kobayashi ,  Shuzo Matsushita ,  Takeo Hoda ,  Hiromu Mukai

发明人： Hiroshi Ootsuka ,  Shinji Tominaga ,  Haruo Kobayashi ,  Shuzo Matsushita ,  Takeo Hoda ,  Hiromu Mukai

IPC分类号： G03B7/091 ,  G03B7/16 ,  G03B7/28

CPC分类号： G03B7/091 ,  G03B7/16 ,  G03B7/28

摘要： A contralight compensation exposure control system which determines as a contralight condition and fires a strobe when there is a difference between the output of a partial light measuring means for measuring the brightness of a portion of a scene to be photographed i.e. the brightness of the main object such as a person, and the output of an average light measuring means for measuring the brightness of comparatively large area of the scene i.e. the brightness of the subordinate object such as the background of the main object. The control circuit of the system inhibits the strobe firing and actuates an exposure compensation means to shift the controlled exposure to the overexposure side when a detecting means detect uncompletion of charging of the main capacitor for firing the strobe even if the contralight condition is detected.

摘要翻译： 一种对照补偿曝光控制系统，当在用于测量要拍摄的场景的一部分的亮度的部分光测量装置的输出之间存在差异时，确定为对向条件并且触发选通，即主要对象的亮度 例如人，以及用于测量场景的相对较大面积的亮度的平均光测量装置的输出，即下属对象的亮度，例如主要对象的背景。 当检测装置检测到用于点火选通的主电容器的充电未完成时，即使检测到对向条件，系统的控制电路也禁止闪光灯点亮，并致动曝光补偿装置以将受控曝光转移到过曝光侧。