公开(公告)号：US10023631B2

公开(公告)日：2018-07-17

申请号：US15795874

申请日：2017-10-27

申请人： UCB Biopharma SPRL

发明人： Ralph Adams ,  Pallavi Bhatta ,  Sam Philip Heywood ,  David Paul Humphreys

IPC分类号： C07K16/18 ,  C07K16/28

摘要： A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.