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    Sequence symmetric modified IgG4 bispecific antibodies
    2.
    发明授权
    Sequence symmetric modified IgG4 bispecific antibodies 有权

    公开(公告)号：US11059911B2

    公开(公告)日：2021-07-13

    申请号：US16242378

    申请日：2019-01-08

    Applicant: UCB Biopharma SPRL

    Inventor： David Paul Humphreys ,  Shirley Jane Peters

    IPC: C07K16/46 ,  C07K16/00

    Abstract: The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain:
    the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and
    optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

    Single linker FabFv antibodies and methods of producing same
    4.
    发明授权
    Single linker FabFv antibodies and methods of producing same 有权

    公开(公告)号：US10457748B2

    公开(公告)日：2019-10-29

    申请号：US14654240

    申请日：2013-12-20

    Applicant: UCB Biopharma SPRL

    Inventor： Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys

    IPC: C07K16/18 ,  C07K16/46 ,  C07K16/28

    Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I): (Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III): V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.

    Sequence symmetric modified IGG4 bispecific antibodies
    5.
    发明授权
    Sequence symmetric modified IGG4 bispecific antibodies 有权

    公开(公告)号：US10221251B2

    公开(公告)日：2019-03-05

    申请号：US14380309

    申请日：2013-02-22

    Applicant: UCB Biopharma SPRL

    Inventor： David Paul Humphreys ,  Shirley Jane Peters

    IPC: C07K16/00 ,  C07K16/46

    Abstract: The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain: the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

    Single Linker FabFv Antibodies and Methods of Producing Same
    6.
    发明申请
    Single Linker FabFv Antibodies and Methods of Producing Same 审中-公开
    单链接FabFv抗体及其生产方法

    公开(公告)号：US20160017057A1

    公开(公告)日：2016-01-21

    申请号：US14654240

    申请日：2013-12-20

    Applicant: UCB BIOPHARMA SPRL

    Inventor： Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys

    IPC: C07K16/46

    CPC classification number: C07K16/468 ,  C07K16/18 ,  C07K16/2878 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/624 ,  C07K2317/64 ,  C07K2317/92 ,  C07K2319/00

    Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I): (Vxx)nVx-Cx-X—V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.

    Abstract translation: 本公开涉及包含三种多肽或由以下三种多肽组成的多特异性抗体分子：a）式（I）的多肽链：（Vxx）nVx-Cx-X-V1; b）式（II）的多肽链：（Vyy）nVy-Cy c）式（III）的多肽：V2其中Vx表示可变结构域，Vxx表示可变结构域，Cx表示恒定区，X表示 接头，V表示可变结构域，Vy表示可变结构域，Vyy表示可变结构域，Cy表示恒定区，V2表示可变结构域，n独立地表示0或1，其中式（I）的多肽链和 排列式（II）的多肽链使得恒定区Cx和Cy配对，并且可变结构域Vx和Vy配对形成结合结构域，并且任选地在V和V 2之间存在二硫键，特别是其中 存在二硫键。 本公开还延伸到包含构建体的药物制剂，编码构建体的DNA和包含其的载体。 本公开进一步扩展到表达构建体的方法，例如在宿主细胞中的方法以及用于配制药物组合物的方法。 本公开还涉及在治疗中使用构建体和制剂。

    Single Linker FabFv Antibodies and Methods of Producing Same
    7.
    发明申请
    Single Linker FabFv Antibodies and Methods of Producing Same 审中-公开

    公开(公告)号：US20200055959A1

    公开(公告)日：2020-02-20

    申请号：US16573893

    申请日：2019-09-17

    Applicant: UCB Biopharma SPRL

    Inventor： Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys

    IPC: C07K16/46 ,  C07K16/18 ,  C07K16/28

    Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I):(Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, nindependently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V1 and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.

    Sequence Symmetric Modified IGG4 Bispecific Antibodies
    10.
    发明申请
    Sequence Symmetric Modified IGG4 Bispecific Antibodies 审中-公开

    公开(公告)号：US20190202937A1

    公开(公告)日：2019-07-04

    申请号：US16242378

    申请日：2019-01-08

    Applicant: UCB Biopharma SPRL

    Inventor： David Paul Humphreys ,  Shirley Jane Peters

    IPC: C07K16/46 ,  C07K16/00

    CPC classification number: C07K16/468 ,  C07K16/00 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/53

    Abstract: The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain:the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

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