公开(公告)号：US20190055225A1

公开(公告)日：2019-02-21

申请号：US16104011

申请日：2018-08-16

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Andrew S. Felts ,  Colleen M. Niswender ,  Rory A. Capstick ,  Paul K. Spearing ,  Sean R. Bollinger

IPC: C07D405/14 ,  C07D471/04 ,  C07D401/12

CPC classification number: C07D405/14 ,  A61P25/00 ,  C07D401/12 ,  C07D407/14 ,  C07D409/14 ,  C07D471/04

Abstract: Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.