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公开(公告)号：US10227343B2
公开(公告)日：2019-03-12
申请号：US15547775
申请日：2016-02-01
发明人： P. Jeffrey Conn , Craig W. Lindsley , Colleen M. Niswender , Corey R. Hopkins , Joanne Bronson , Yong-Jin Wu , Kyle Emmitte , Joe Panarese , Darren W. Engers , Julie Engers
IPC分类号： C07D471/04 , A61K31/496 , A61K31/437 , A61K31/554 , A61K31/553 , C07D487/04 , A61K31/4985 , A61K31/4725 , A61K31/541 , A61K31/4745 , A61K31/506 , A61K31/5377 , A61K31/502 , C07D401/12 , A61K31/4375 , C07D519/00 , A61K31/519 , A61K45/06
摘要： Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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公开(公告)号：US20220259190A1
公开(公告)日：2022-08-18
申请号：US17730112
申请日：2022-04-26
发明人： P. Jeffrey Conn , Craig W. Lindsley , Andrew S. Felts , Colleen M. Niswender , Rory A. Capstick , Paul K. Spearing , Sean R. Bollinger
IPC分类号： C07D405/14 , C07D407/14 , A61P25/00 , C07D409/14 , C07D519/00 , C07D401/12 , C07D471/04
摘要： Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.
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公开(公告)号：US11427573B2
公开(公告)日：2022-08-30
申请号：US16639539
申请日：2018-08-16
发明人： P. Jeffrey Conn , Craig W. Lindsley , Andrew S. Felts , Colleen M. Niswender , Rory A. Capstick , Paul K. Spearing , Sean R. Bollinger
IPC分类号： C07D405/14 , C07D407/14 , A61P25/00 , C07D409/14 , C07D519/00 , C07D401/12 , C07D471/04
摘要： Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.
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4.发明申请公开(公告)号：US20200165232A1
公开(公告)日：2020-05-28
申请号：US16626837
申请日：2018-06-28
发明人： P. Jeffrey Conn , Craig W. Lindsley , Andrew S. Felts , Colleen M. Niswender , Rory A. Capstick , Paul K. Spearing , Sean R. Bollinger
IPC分类号： C07D405/14 , C07D409/14 , C07D401/12 , C07D417/14 , C07D401/14
摘要： Pyridine quinoline compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.
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公开(公告)号：US10221172B2
公开(公告)日：2019-03-05
申请号：US15540239
申请日：2016-01-13
发明人： P. Jeffrey Conn , Corey R. Hopkins , Craig W. Lindsley , Colleen M. Niswender , Darren W. Engers , Sean Bollinger
IPC分类号： C07D471/04 , C07D519/00 , C07D487/04 , A61K31/55 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K45/06
摘要： Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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公开(公告)号：US20180022745A1
公开(公告)日：2018-01-25
申请号：US15547775
申请日：2016-02-01
发明人： P. Jeffrey Conn , Craig W. Lindsley , Colleen M. Niswender , Corey R. Hopkins , Joanne Bronson , Yong-Jin Wu , Kyle Emmitte , Joe Panarese , Darren W. Engers , Julie Engers
IPC分类号： C07D471/04 , A61K31/496 , A61K31/437 , A61K31/554 , A61K31/553 , C07D487/04 , A61K31/4985 , A61K31/4725 , A61K31/541 , A61K31/4745 , A61K31/506 , A61K31/5377 , A61K31/502 , C07D401/12 , A61K31/4375 , C07D519/00 , A61K31/519 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/4725 , A61K31/4745 , A61K31/496 , A61K31/4985 , A61K31/502 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/553 , A61K31/554 , A61K45/06 , C07D401/12 , C07D487/04 , C07D519/00 , A61K2300/00
摘要： Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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公开(公告)号：US20180022744A1
公开(公告)日：2018-01-25
申请号：US15540239
申请日：2016-01-13
发明人： P. Jeffrey Conn , Corey R. Hopkins , Craig W. Lindsley , Colleen M. Niswender , Darren W. Engers , Sean Bollinger
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D487/04 , C07D519/00 , A61K2300/00
摘要： Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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公开(公告)号：US20180021312A1
公开(公告)日：2018-01-25
申请号：US15540972
申请日：2016-01-13
发明人： P. Jeffrey Conn , Corey R. Hopkins , Craig W. Lindsley , Colleen M. Niswender , Darren W. Engers , Joe Panarese , Sean Bollinger , Julie Engers
IPC分类号： A61K31/423 , C07D413/12 , A61K45/06 , C07D471/04 , A61K31/437 , A61K31/4985
CPC分类号： A61K31/423 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K2300/00 , C07D413/12 , C07D471/04 , C07D487/04
摘要： Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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公开(公告)号：US10508105B2
公开(公告)日：2019-12-17
申请号：US16104011
申请日：2018-08-16
发明人： P. Jeffrey Conn , Craig W. Lindsley , Andrew S. Felts , Colleen M. Niswender , Rory A. Capstick , Paul K. Spearing , Sean R. Bollinger
IPC分类号： C07D405/14 , C07D401/12 , C07D471/04 , C07D407/14 , C07D409/14 , A61P25/00
摘要： Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.
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10.发明申请公开(公告)号：US20190055225A1
公开(公告)日：2019-02-21
申请号：US16104011
申请日：2018-08-16
发明人： P. Jeffrey Conn , Craig W. Lindsley , Andrew S. Felts , Colleen M. Niswender , Rory A. Capstick , Paul K. Spearing , Sean R. Bollinger
IPC分类号： C07D405/14 , C07D471/04 , C07D401/12
CPC分类号： C07D405/14 , A61P25/00 , C07D401/12 , C07D407/14 , C07D409/14 , C07D471/04
摘要： Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.
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