公开(公告)号：US20220259190A1

公开(公告)日：2022-08-18

申请号：US17730112

申请日：2022-04-26

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Andrew S. Felts ,  Colleen M. Niswender ,  Rory A. Capstick ,  Paul K. Spearing ,  Sean R. Bollinger

IPC: C07D405/14 ,  C07D407/14 ,  A61P25/00 ,  C07D409/14 ,  C07D519/00 ,  C07D401/12 ,  C07D471/04

Abstract: Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.

公开(公告)号：US11427573B2

公开(公告)日：2022-08-30

申请号：US16639539

申请日：2018-08-16

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Andrew S. Felts ,  Colleen M. Niswender ,  Rory A. Capstick ,  Paul K. Spearing ,  Sean R. Bollinger

IPC: C07D405/14 ,  C07D407/14 ,  A61P25/00 ,  C07D409/14 ,  C07D519/00 ,  C07D401/12 ,  C07D471/04

Abstract: Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.

公开(公告)号：US10961253B2

公开(公告)日：2021-03-30

申请号：US16347450

申请日：2017-11-07

Applicant: Vanderbilt University

Inventor： Craig W. Lindsley ,  Darren W. Engers ,  P. Jeffrey Conn ,  Katrina A. Bollinger ,  Rory Capstick ,  Paul Spearing ,  Sean R. Bollinger

IPC: C07D495/04

Abstract: Disclosed herein are pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine and pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine compounds, which may be useful as positive allostenc modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

公开(公告)号：US20200165232A1

公开(公告)日：2020-05-28

申请号：US16626837

申请日：2018-06-28

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Andrew S. Felts ,  Colleen M. Niswender ,  Rory A. Capstick ,  Paul K. Spearing ,  Sean R. Bollinger

IPC: C07D405/14 ,  C07D409/14 ,  C07D401/12 ,  C07D417/14 ,  C07D401/14

Abstract: Pyridine quinoline compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.

公开(公告)号：US11319304B2

公开(公告)日：2022-05-03

申请号：US16626837

申请日：2018-06-28

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Andrew S. Felts ,  Colleen M. Niswender ,  Rory A. Capstick ,  Paul K. Spearing ,  Sean R. Bollinger

IPC: C07D405/14 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14

Abstract: Pyridine quinoline compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.

公开(公告)号：US20200291019A1

公开(公告)日：2020-09-17

申请号：US16639539

申请日：2018-08-16

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Andrew S. Felts ,  Colleen M. Niswender ,  Rory A. Capstick ,  Paul K. Spearing ,  Sean R. Bollinger

IPC: C07D471/04 ,  C07D519/00 ,  C07D409/14 ,  C07D405/14

Abstract: Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.

公开(公告)号：US20200181166A1

公开(公告)日：2020-06-11

申请号：US16347446

申请日：2017-11-07

Applicant: Vanderbilt University

Inventor： Craig W. Lindsley ,  Darren W. Engers ,  P. Jeffrey Conn ,  Sean R. Bollinger ,  Julie L. Engers

IPC: C07D495/14

Abstract: Disclosed herein are pyrido[3′,2′:4,5]thieno[2,3-d]pyridazin-8-amine and thieno[2,3-c:4,5-d′]dipyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

公开(公告)号：US11008335B2

公开(公告)日：2021-05-18

申请号：US16347446

申请日：2017-11-07

Applicant: Vanderbilt University

Inventor： Craig W. Lindsley ,  Darren W. Engers ,  P. Jeffrey Conn ,  Sean R. Bollinger ,  Julie L. Engers

IPC: C07D495/14

Abstract: Disclosed herein are pyrido[3′,2′:4,5]thieno[2,3-d]pyridazin-8-amine and thieno[2,3-c:4,5-d′]dipyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

公开(公告)号：US10508105B2

公开(公告)日：2019-12-17

申请号：US16104011

申请日：2018-08-16

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Andrew S. Felts ,  Colleen M. Niswender ,  Rory A. Capstick ,  Paul K. Spearing ,  Sean R. Bollinger

IPC: C07D405/14 ,  C07D401/12 ,  C07D471/04 ,  C07D407/14 ,  C07D409/14 ,  A61P25/00

Abstract: Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.

公开(公告)号：US20190330225A1

公开(公告)日：2019-10-31

申请号：US16347450

申请日：2017-11-07

Applicant: Vanderbilt University

Inventor： Craig W. Lindsley ,  Darren W. Engers ,  P. Jeffrey Conn ,  Katrina A. Bollinger ,  Rory Capstick ,  Paul Spearing ,  Sean R. Bollinger

IPC: C07D495/04

Abstract: Disclosed herein are pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine and pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine compounds, which may be useful as positive allostenc modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.