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公开(公告)号:US08497303B2
公开(公告)日:2013-07-30
申请号:US12810962
申请日:2009-01-05
申请人: David B. Wurn , David A. Wilson , Bruce A. Barner , Cynthia L. Rand , Matthew D. Miller , Michael J. Johnson
发明人: David B. Wurn , David A. Wilson , Bruce A. Barner , Cynthia L. Rand , Matthew D. Miller , Michael J. Johnson
IPC分类号: A61K9/08 , A61K47/10 , A61K31/192 , A61K31/167
CPC分类号: A61K31/167 , A61K9/08 , A61K31/192 , A61K47/10
摘要: A method to enhance solubility of an active compound comprises combining an active compound, having an aqueous solubility that is less than or equal to about 10 mg/mL, and an amount of methoxypolyethylene glycol that is sufficient to increase the aqueous solubility of the active compound. Enhancement of aqueous solubility for this combination may be significantly greater than that of an active compound in combination with an equivalent amount of polyethylene glycol. Particularly enhanced solubility is shown where a small amount of water is also included. The invention may be used in a wide variety of applications, such as for pharmaceutical, agricultural, antimicrobial, and personal care products.
摘要翻译: 提高活性化合物的溶解度的方法包括组合具有小于或等于约10mg / mL的水溶解度的活性化合物和足以提高活性化合物的水溶性的甲氧基聚乙二醇的量 。 该组合的水溶性的增强可以显着大于活性化合物与等量的聚乙二醇的组合。 显示特别增加的溶解度,其中也包括少量的水。 本发明可以用于各种各样的应用,例如用于制药,农业,抗微生物和个人护理产品。
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公开(公告)号:US20100286277A1
公开(公告)日:2010-11-11
申请号:US12810962
申请日:2009-01-05
申请人: David B. Wurm , David A. Wilson , Bruce A. Barner , Cynthia L. Rand , Matthew D. Miller , Michael J. Johnson
发明人: David B. Wurm , David A. Wilson , Bruce A. Barner , Cynthia L. Rand , Matthew D. Miller , Michael J. Johnson
IPC分类号: A61K31/192 , A61K31/167 , A01P13/00 , A01P21/00 , A61Q17/00 , A61K8/36 , A61K8/42 , A01N37/10 , A01N37/18
CPC分类号: A61K31/167 , A61K9/08 , A61K31/192 , A61K47/10
摘要: A method to enhance solubility of an active compound comprises combining an active compound, having an aqueous solubility that is less than or equal to about 10 mg/mL, and an amount of methoxypolyethylene glycol that is sufficient to increase the aqueous solubility of the active compound. Enhancement of aqueous solubility for this combination may be significantly greater than that of an active compound in combination with an equivalent amount of polyethylene glycol. Particularly enhanced solubility is shown where a small amount of water is also included. The invention may be used in a wide variety of applications, such as for pharmaceutical, agricultural, antimicrobial, and personal care products.
摘要翻译: 提高活性化合物的溶解度的方法包括组合具有小于或等于约10mg / mL的水溶解度的活性化合物和足以增加活性化合物的水溶性的甲氧基聚乙二醇的量 。 该组合的水溶性的增强可以显着大于活性化合物与等量的聚乙二醇的组合。 显示出特别增加的溶解度,其中还包括少量的水。 本发明可以用于各种各样的应用,例如用于制药,农业,抗微生物和个人护理产品。
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公开(公告)号:US3955879A
公开(公告)日:1976-05-11
申请号:US409580
申请日:1973-10-25
申请人: Horst Witzke , Matthew D. Miller
发明人: Horst Witzke , Matthew D. Miller
CPC分类号: G02F1/1523
摘要: An electrochromic device comprises, in a layered structure, a first electrode, an electrochromic material, an electrolyte and a back electrode which is of a material different than said first electrode. The device is characterized as having a nonlinear voltage response, a well defined threshhold, and an internal electromotive force which is uniquely determined by the color state of the device.
摘要翻译: 电致变色装置在分层结构中包括第一电极,电致变色材料,电解质和与第一电极不同的材料的背电极。 该器件的特征在于具有非线性电压响应,良好限定的阈值和由该器件的颜色状态唯一确定的内部电动势。
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